Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385672011> ?p ?o ?g. }
- W4385672011 endingPage "157" @default.
- W4385672011 startingPage "135" @default.
- W4385672011 abstract "Immune-inflammatory mechanisms seem to play a relevant role in neurodegenerative disorders affecting motor systems, particularly Parkinson's disease, where activity changes in inflammatory cells and evidence of neuroinflammation in experimental models and patients is available. Amyotrophic lateral sclerosis is also characterized by neuroinflammatory changes that involve primarily glial cells, both microglia and astrocytes, as well as systemic immune dysregulation associated with more rapid progression. Similarly, the exploration of gut dysbiosis in these two prototypical neurodegenerative motor disorders is advancing rapidly. Altered composition of gut microbial constituents and related metabolic and putative functional pathways is supporting a pathophysiological link that is currently explored in preclinical, germ-free animal models. Less compelling, but still intriguing, evidence suggests that motor neurodevelopmental disorders, e.g., Tourette syndrome, are associated with abnormal trajectories of maturation that include also immune system development. Microglia has a key role also in these disorders, and new therapeutic avenues aiming at its modulation are exciting prospects. Preclinical and clinical research on the role of gut dysbiosis in Tourette syndrome and related behavioral disorders is still in its infancy, but early findings support the rationale to delve deeper into its contribution to neural and immune maturation abnormalities in its spectrum." @default.
- W4385672011 created "2023-08-09" @default.
- W4385672011 creator A5050605775 @default.
- W4385672011 creator A5070897359 @default.
- W4385672011 date "2023-01-01" @default.
- W4385672011 modified "2023-10-14" @default.
- W4385672011 title "Immunology and microbiome: Implications for motor systems" @default.
- W4385672011 cites W1545634912 @default.
- W4385672011 cites W1549775244 @default.
- W4385672011 cites W1561041814 @default.
- W4385672011 cites W1956862481 @default.
- W4385672011 cites W1974924674 @default.
- W4385672011 cites W1976266513 @default.
- W4385672011 cites W1980789245 @default.
- W4385672011 cites W1981329326 @default.
- W4385672011 cites W1984861969 @default.
- W4385672011 cites W1987138690 @default.
- W4385672011 cites W1990932486 @default.
- W4385672011 cites W1997211020 @default.
- W4385672011 cites W2001442200 @default.
- W4385672011 cites W2015283405 @default.
- W4385672011 cites W2015412022 @default.
- W4385672011 cites W2018397294 @default.
- W4385672011 cites W2019099624 @default.
- W4385672011 cites W2019706623 @default.
- W4385672011 cites W2019863741 @default.
- W4385672011 cites W2025810715 @default.
- W4385672011 cites W2026430696 @default.
- W4385672011 cites W2027004879 @default.
- W4385672011 cites W2029319167 @default.
- W4385672011 cites W2030500910 @default.
- W4385672011 cites W2033617297 @default.
- W4385672011 cites W2034099577 @default.
- W4385672011 cites W2041642139 @default.
- W4385672011 cites W2042698977 @default.
- W4385672011 cites W2048743082 @default.
- W4385672011 cites W2052442579 @default.
- W4385672011 cites W2055934664 @default.
- W4385672011 cites W2058522899 @default.
- W4385672011 cites W2060139683 @default.
- W4385672011 cites W2060189047 @default.
- W4385672011 cites W2062916819 @default.
- W4385672011 cites W2073136915 @default.
- W4385672011 cites W2081836849 @default.
- W4385672011 cites W2085571457 @default.
- W4385672011 cites W2088170171 @default.
- W4385672011 cites W2089889142 @default.
- W4385672011 cites W2096327192 @default.
- W4385672011 cites W2096500024 @default.
- W4385672011 cites W2096776344 @default.
- W4385672011 cites W2101243397 @default.
- W4385672011 cites W2103711259 @default.
- W4385672011 cites W2108396440 @default.
- W4385672011 cites W2117029190 @default.
- W4385672011 cites W2117434453 @default.
- W4385672011 cites W2123848058 @default.
- W4385672011 cites W2128492849 @default.
- W4385672011 cites W2141283639 @default.
- W4385672011 cites W2141459724 @default.
- W4385672011 cites W2147707911 @default.
- W4385672011 cites W2148898943 @default.
- W4385672011 cites W2151477002 @default.
- W4385672011 cites W2154945114 @default.
- W4385672011 cites W2163065425 @default.
- W4385672011 cites W2163269381 @default.
- W4385672011 cites W2163487275 @default.
- W4385672011 cites W2164643225 @default.
- W4385672011 cites W2170205373 @default.
- W4385672011 cites W2261364877 @default.
- W4385672011 cites W2304886140 @default.
- W4385672011 cites W2411185224 @default.
- W4385672011 cites W2434635261 @default.
- W4385672011 cites W2469928790 @default.
- W4385672011 cites W2509213166 @default.
- W4385672011 cites W2524848139 @default.
- W4385672011 cites W2536503303 @default.
- W4385672011 cites W2552495069 @default.
- W4385672011 cites W2572710398 @default.
- W4385672011 cites W2580573536 @default.
- W4385672011 cites W2587959748 @default.
- W4385672011 cites W2602156859 @default.
- W4385672011 cites W2605554476 @default.
- W4385672011 cites W2605569345 @default.
- W4385672011 cites W2607829140 @default.
- W4385672011 cites W2622719965 @default.
- W4385672011 cites W2638382976 @default.
- W4385672011 cites W2725043130 @default.
- W4385672011 cites W2746835184 @default.
- W4385672011 cites W2759952551 @default.
- W4385672011 cites W2772742229 @default.
- W4385672011 cites W2774516418 @default.
- W4385672011 cites W2782592927 @default.
- W4385672011 cites W2782946155 @default.
- W4385672011 cites W2789725922 @default.
- W4385672011 cites W2792437808 @default.
- W4385672011 cites W2793037886 @default.
- W4385672011 cites W2796039846 @default.
- W4385672011 cites W2804758672 @default.