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- W4385680810 abstract "To explore molecular mechanisms by which umbilical cord-derived mesenchymal stem cells suppress the development of GVHD after bone marrow hematopoietic stem cell transplantation.A mouse model of aGVHD was constructed after bone marrow hematopoietic stem cell transplantation, and the umbilical cord-derived mesenchymal stem cells were cultured, and then injected into the aGVHD mouse model, so as to investigate its prophylactic efficacy. Prophylactic effect of the exosomes isolated from umbilical cord-derived mesenchymal stem cells on aGVHD mice was assessed. Sequencing analysis of miRNA from exosomes was performed.aGVHD model was successfully constructed after hematopoietic stem cell transplantation. By injecting umbilical cord-derived mesenchymal stem cells into the GVHD mouse model, it was found that the treatment significantly prolonged survival time of mice compared to the untreated group. Injection exosomes derived from umbilical cord-derived mesenchymal stem cells into the GVHD mouse model significantly prolonged the survival time of mice compared to the untreated group. High-throughput sequencing data showed that microRNA such as miR-21 in exosomes isolated from umbilical cord-derived mesenchymal stem cells, which mainly affected the signaling pathways such as cell adhesion, RNA degradation.The umbilical cord-derived mesenchymal stem cells can prevent the occurrence of aGVHD after HSCT, which is mediate by MicroRNA in the exosomes derived from umbilical cord-derived mesenchymal stem cells.人脐带间充质干细胞通过外泌体miRNA预防骨髓干细胞移植后aGVHD的效应和机制研究.探索脐带间充质干细胞抑制骨髓干细胞移植后GVHD发生的分子机制.通过构建小鼠骨髓干细胞移植后急性移植物抗宿主病（aGVHD）的模型，并将脐带间充质干细胞用于aGVHD小鼠模型中观察其预防效应。同时通过分离脐带间充质干细胞外泌体，观察外泌体对aGVHD小鼠的预防效应。通过对脐带间充质干细胞和外泌体进行miRNA测序、分析和验证，探索脐带间充质干细胞外泌体预防骨髓干细胞移植后aGVHD的分子机制.成功构建了小鼠骨髓干细胞移植后aGVHD模型。与骨髓干细胞移植后aGVHD模型小鼠相比，注射脐带间充质干细胞能够降低移植小鼠aGVHD评分，延长小鼠的生存时间。而脐带间充质干细胞的外泌体注射同样具有降低aGVHD评分，延长移植小鼠生存时间的疗效。高通量测序结果显示，脐带间充质干细胞的外泌体中富含miR-21等miRNA分子，主要影响细胞粘附、细胞RNA降解等信号通路.脐带间充质干细胞能够预防骨髓干细胞移植后aGVHD的发生，该效应可能由脐带间充质干细胞的外泌体中miRNA所介导." @default.
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- W4385680810 date "2023-08-08" @default.
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- W4385680810 title "[Human Umbilical Cord-Derived Mesenchymal Stem Cells Prevent Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation Via Exosome-Mediated MicroRNA and Its Mechanism]." @default.
- W4385680810 doi "https://doi.org/10.19746/j.cnki.issn.1009-2137.2023.04.037" @default.
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