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• W4385683636 abstract "Pediatric Blood & CancerVolume 70, Issue 11 e30619 LETTER TO THE EDITOR Sarcoid-like reaction in a child following prolonged therapeutic exposure to dabrafenib and trametinib for BRAF V600E mutated hypothalamic/chiasmatic glioma Mari Wilhelmsson, Mari Wilhelmsson Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Women´s and Children´s Health, Karolinska Institute, Stockholm, SwedenSearch for more papers by this authorFoo Jen Chun, Foo Jen Chun Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorRae S. M. Yeung, Rae S. M. Yeung Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorFiona Krtizinger, Fiona Krtizinger orcid.org/0009-0004-0155-7377 Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorTara McKeown, Tara McKeown Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorAilish Coblentz, Ailish Coblentz Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorBirgit Ertl-Wagner, Birgit Ertl-Wagner Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorUri Tabori, Uri Tabori Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorUte Bartels, Ute Bartels Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorAnirban Das, Corresponding Author Anirban Das [email protected] Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada Correspondence Anirban Das, Division of Hematology Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G1X8, Canada. Email: [email protected]Search for more papers by this author Mari Wilhelmsson, Mari Wilhelmsson Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada Department of Women´s and Children´s Health, Karolinska Institute, Stockholm, SwedenSearch for more papers by this authorFoo Jen Chun, Foo Jen Chun Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorRae S. M. Yeung, Rae S. M. Yeung Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorFiona Krtizinger, Fiona Krtizinger orcid.org/0009-0004-0155-7377 Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorTara McKeown, Tara McKeown Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorAilish Coblentz, Ailish Coblentz Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorBirgit Ertl-Wagner, Birgit Ertl-Wagner Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorUri Tabori, Uri Tabori Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorUte Bartels, Ute Bartels Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, CanadaSearch for more papers by this authorAnirban Das, Corresponding Author Anirban Das [email protected] Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada Correspondence Anirban Das, Division of Hematology Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G1X8, Canada. Email: [email protected]Search for more papers by this author First published: 09 August 2023 https://doi.org/10.1002/pbc.30619Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Lassaletta A, Guerreiro Stucklin A, Ramaswamy V, et al. Profound clinical and radiological response to BRAF inhibition in a 2-month-old diencephalic child with hypothalamic/chiasmatic glioma. Pediatr Blood Cancer. 2016; 63(11): 2038-2041. doi:10.1002/pbc.26086 2Chiu B, Chan J, Das S, Alshamma Z, Sergi C. Pediatric sarcoidosis: a review with emphasis on early onset and high-risk sarcoidosis and diagnostic challenges. Diagnostics (Basel). 2019; 9(4): 160. doi:10.3390/diagnostics9040160 3Huh JY, Moon DS, Song JW. Sarcoid-like reaction in patients with malignant tumors: long-term clinical course and outcomes. Front Med (Lausanne). 2022; 9:884386. doi:10.3389/fmed.2022.884386 4Beijer E, Roodenburg-Benschop C, Schimmelpennink MC, Grutters JC, Meek B, Veltkamp M. Elevated serum amyloid a levels are not specific for sarcoidosis but associate with a fibrotic pulmonary phenotype. Cells. 2021; 10(3): 585. doi:10.3390/cells10030585 5Ascierto PA, Dummer R. Immunological effects of BRAF+MEK inhibition. Oncoimmunology. 2018; 7(9):e1468955. doi:10.1080/2162402X.2018.1468955 6Baumann D, Hagele T, Mochayedi J, et al. Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy. Nat Commun. 2020; 11(1): 2176. doi:10.1038/s41467-020-15979-2 7Crouser ED, Maier LA, Wilson KC, et al. Diagnosis and detection of sarcoidosis. An official American Thoracic Society clinical practice guideline. Am J Respir Crit Care Med. 2020; 201(8): e26-e51. doi:10.1164/rccm.202002-0251ST 8Anastasopoulou A, Diamantopoulos PT, Skalioti C, et al. The diagnosis and management of sarcoid-like reactions in patients with melanoma treated with BRAF and MEK inhibitors. A case series and review of the literature. Ther Adv Med Oncol. 2021; 13:17588359211047349. doi:10.1177/17588359211047349 9Bala VM, Mitsogianni M, Laschos K, et al. Mediastinal and hilar sarcoid-like reaction in a patient treated with dabrafenib and trametinib for metastatic melanoma: a case report and review of the literature. Mol Clin Oncol. 2022; 16(5): 99. doi:10.3892/mco.2022.2532 10Dando EE, Rosenbach M, English III JC. Granulomatous drug reactions from targeted therapeutics. Med Res Arch. 2020; 8(6). doi:10.18103/mra.v8i6.2138 11Park JJ, Hawryluk EB, Tahan SR, Flaherty K, Christiani DC. Genetic susceptibility to sarcoidosis, a chronic inflammatory disorder. Am J Respir Crit Care Med. 2012; 186(9): 816-818. doi:10.1164/rccm.201209-1582ED 12van Moorsel CH, Christiani DC. Genetic susceptibility to sarcoidosis, a chronic inflammatory disorder. Am J Respir Crit Care Med. 2012; 186(9): 816-818. doi:10.1164/rccm.201209-1582ED 13Calender A, Weichhart T, Valeyre D, Pacheco Y. Current Insights in Genetics of Sarcoidosis: Functional and Clinical Impacts. J Clin Med. 2020; 9(8): 2633. doi:10.3390/jcm9082633 14Caso F, Rigante D, Vitale A, et al. Monogenic autoinflammatory syndromes: state of the art on genetic, clinical, and therapeutic issues. Int J Rheumatol. 2013; 2013:513782. doi:10.1155/2013/513782 15Caso F, Galozzi P, Costa L, Sfriso P, Cantarini L, Punzi L. Autoinflammatory granulomatous diseases: from Blau syndrome and early-onset sarcoidosis to NOD2-mediated disease and Crohn's disease. RMD Open. 2015; 1(1):e000097. doi:10.1136/rmdopen-2015-000097 16Tsao YP, Tseng FY, Chao CW, et al. NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression. J Clin Invest. 2023; 133(3):e157272. doi:10.1172/jci157272 17Nobre L, Zapotocky M, Ramaswamy V, et al. Outcomes of BRAF V600E pediatric gliomas treated with targeted BRAF inhibition. JCO Precis Oncol. 2020; 4: 561-571. doi:10.1200/PO.19.00298 Volume70, Issue11November 2023e30619 ReferencesRelatedInformation" @default.
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