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- W4385684493 abstract "Abstract Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15–20% of SLE patients develop the disease during childhood or adolescence (juvenile-onset SLE/jSLE). Patients with jSLE exhibit more variable and severe disease when compared to patients with disease-onset during adulthood. Neuropsychiatric (NP) involvement is a clinically heterogenous and potentially severe complication. Published reports on the incidence and prevalence of NP-jSLE are scarce, and the exact pathophysiology is poorly understood. This manuscript provides a review of the existing literature, suggesting NP involvement in 13.5–51% of jSLE patients. Among patients with NP-jSLE affecting the CNS, we propose two main subgroups: (i) a chronic progressive, predominantly type 1 interferon-driven form that poorly responds to currently used treatments, and (ii) an acutely aggressive form that usually presents early during the disease that may be primarily mediated by auto-reactive effector lymphocytes. While this hypothesis requires to be tested in large collaborative international cohort studies, it may offer future patient stratification and individualised care." @default.
- W4385684493 created "2023-08-10" @default.
- W4385684493 creator A5010338029 @default.
- W4385684493 creator A5016576825 @default.
- W4385684493 creator A5062769134 @default.
- W4385684493 creator A5075268551 @default.
- W4385684493 date "2023-08-09" @default.
- W4385684493 modified "2023-09-26" @default.
- W4385684493 title "Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE)" @default.
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