Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385684558> ?p ?o ?g. }
- W4385684558 abstract "Abstract INTRODUCTION Tau and neurodegeneration strongly correlate with cognitive impairment, as compared to amyloid. However, their contribution in explaining cognition and predicting cognitive decline in memory clinics remains unclarified. METHODS We included 94 participants with Mini‐Mental State Examination (MMSE), tau positron emission tomography (PET), amyloidPET, fluorodeoxyglucose (FDG)PET, and MRI scans from Geneva Memory Center. Linear regression and mediation analyses tested the independent and combined association between biomarkers, cognitive performance, and decline. Linear mixed‐effects and Cox proportional hazards models assessed biomarkers’ prognostic values. RESULTS Metabolism had the strongest association with cognition (r = 0.712; p < 0.001), followed by tau (r = ‐0.682; p < 0.001). Neocortical tau showed the strongest association with cognitive decline (r = ‐0.677; p < 0.001). Metabolism mediated the association between tau and cognition and marginally mediated the one with decline. Tau positivity represented the strongest risk factor for decline (hazard ratio = 32). DISCUSSION Tau and neurodegeneration synergistically contribute to global cognitive impairment while tau drives decline. The tauPET superior prognostic value supports its implementation in memory clinics. HIGHLIGHTS Hypometabolism has the strongest association with concurrent cognitive impairment. Neocortical tau pathology is the main determinant of cognitive decline over time. FDG‐PET has a superior value compared to MRI as a measure of neurodegeneration. The prognostic value of tau‐PET exceeded all other neuroimaging modalities." @default.
- W4385684558 created "2023-08-10" @default.
- W4385684558 creator A5014971081 @default.
- W4385684558 creator A5020641788 @default.
- W4385684558 creator A5037620274 @default.
- W4385684558 creator A5046429548 @default.
- W4385684558 creator A5051868596 @default.
- W4385684558 creator A5066000640 @default.
- W4385684558 creator A5068721045 @default.
- W4385684558 creator A5068751115 @default.
- W4385684558 creator A5072393749 @default.
- W4385684558 creator A5078927818 @default.
- W4385684558 date "2023-08-09" @default.
- W4385684558 modified "2023-10-17" @default.
- W4385684558 title "The impact of tau deposition and hypometabolism on cognitive impairment and longitudinal cognitive decline" @default.
- W4385684558 cites W1915842929 @default.
- W4385684558 cites W1975914990 @default.
- W4385684558 cites W1990752558 @default.
- W4385684558 cites W1990816744 @default.
- W4385684558 cites W2005821483 @default.
- W4385684558 cites W2042795487 @default.
- W4385684558 cites W2043020182 @default.
- W4385684558 cites W2065174137 @default.
- W4385684558 cites W2076960269 @default.
- W4385684558 cites W2082465900 @default.
- W4385684558 cites W2108468919 @default.
- W4385684558 cites W2124030567 @default.
- W4385684558 cites W2137348301 @default.
- W4385684558 cites W2150480085 @default.
- W4385684558 cites W2155277084 @default.
- W4385684558 cites W2155298532 @default.
- W4385684558 cites W2160597466 @default.
- W4385684558 cites W2293378393 @default.
- W4385684558 cites W2346847240 @default.
- W4385684558 cites W2529649944 @default.
- W4385684558 cites W2582524520 @default.
- W4385684558 cites W2592503176 @default.
- W4385684558 cites W2626001339 @default.
- W4385684558 cites W2738088587 @default.
- W4385684558 cites W2763470121 @default.
- W4385684558 cites W2794753783 @default.
- W4385684558 cites W2798054687 @default.
- W4385684558 cites W2809516213 @default.
- W4385684558 cites W2887375324 @default.
- W4385684558 cites W2905538154 @default.
- W4385684558 cites W2910556588 @default.
- W4385684558 cites W2943476107 @default.
- W4385684558 cites W2943828894 @default.
- W4385684558 cites W2948815538 @default.
- W4385684558 cites W2954905185 @default.
- W4385684558 cites W2973007151 @default.
- W4385684558 cites W3019122005 @default.
- W4385684558 cites W3025228866 @default.
- W4385684558 cites W3041479049 @default.
- W4385684558 cites W3063699252 @default.
- W4385684558 cites W3113674672 @default.
- W4385684558 cites W3174860908 @default.
- W4385684558 cites W3187999815 @default.
- W4385684558 cites W3206813110 @default.
- W4385684558 cites W4200531219 @default.
- W4385684558 cites W4241074797 @default.
- W4385684558 cites W4282016234 @default.
- W4385684558 cites W4283687741 @default.
- W4385684558 cites W4287378024 @default.
- W4385684558 cites W4288843991 @default.
- W4385684558 cites W4295227033 @default.
- W4385684558 cites W4311461758 @default.
- W4385684558 doi "https://doi.org/10.1002/alz.13355" @default.
- W4385684558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37555516" @default.
- W4385684558 hasPublicationYear "2023" @default.
- W4385684558 type Work @default.
- W4385684558 citedByCount "4" @default.
- W4385684558 countsByYear W43856845582023 @default.
- W4385684558 crossrefType "journal-article" @default.
- W4385684558 hasAuthorship W4385684558A5014971081 @default.
- W4385684558 hasAuthorship W4385684558A5020641788 @default.
- W4385684558 hasAuthorship W4385684558A5037620274 @default.
- W4385684558 hasAuthorship W4385684558A5046429548 @default.
- W4385684558 hasAuthorship W4385684558A5051868596 @default.
- W4385684558 hasAuthorship W4385684558A5066000640 @default.
- W4385684558 hasAuthorship W4385684558A5068721045 @default.
- W4385684558 hasAuthorship W4385684558A5068751115 @default.
- W4385684558 hasAuthorship W4385684558A5072393749 @default.
- W4385684558 hasAuthorship W4385684558A5078927818 @default.
- W4385684558 hasBestOaLocation W43856845581 @default.
- W4385684558 hasConcept C126322002 @default.
- W4385684558 hasConcept C143998085 @default.
- W4385684558 hasConcept C15744967 @default.
- W4385684558 hasConcept C169760540 @default.
- W4385684558 hasConcept C169900460 @default.
- W4385684558 hasConcept C199374082 @default.
- W4385684558 hasConcept C2775842073 @default.
- W4385684558 hasConcept C2776925932 @default.
- W4385684558 hasConcept C2779134260 @default.
- W4385684558 hasConcept C2779483572 @default.
- W4385684558 hasConcept C2781073650 @default.
- W4385684558 hasConcept C2984863031 @default.
- W4385684558 hasConcept C2984915365 @default.
- W4385684558 hasConcept C50382708 @default.
- W4385684558 hasConcept C58693492 @default.