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- W4385684660 abstract "Abstract Aim In extracerebral vascular beds cystathionine‐gamma lyase (CSE) activity plays a vasodilatory role but the role of this hydrogen sulfide (H 2 S) producing enzyme in the intracerebral arterioles remain poorly understood. We hypothesized a similar function in the intracerebral arterioles. Methods Intracerebral arterioles were isolated from wild type C57BL/6J mouse (9–12 months old) brains and from human brain biopsies. The function (contractility and secondary dilatation) of the intracerebral arterioles was tested ex vivo by pressure myography using a perfusion set‐up. Reverse transcription polymerase chain reaction was used for detecting CSE expression. Results CSE is expressed in human and mouse intracerebral arterioles. CSE inhibition with L‐propargylglycine (PAG) significantly dampened the K + ‐induced vasoconstriction in intracerebral arterioles of both species (% of maximum contraction: in human control: 45.4 ± 2.7 versus PAG: 27 ± 5.2 and in mouse control: 50 ± 1.5 versus PAG: 33 ± 5.2) but did not affect the secondary dilatation. This effect of PAG was significantly reversed by the H 2 S donor sodium hydrosulfide (NaSH) in human (PAG + NaSH: 38.8 ± 7.2) and mouse (PAG + NaSH: 41.7 ± 3.1) arterioles, respectively. The endothelial NO synthase (eNOS) inhibitor, Nω‐Nitro‐l‐arginine methyl ester (L‐NAME), and the inhibitor of soluble guanylate cyclase (sGC), 1H‐[1,2,4]oxadiazolo[4,3‐a]quinoxalin‐1‐one (ODQ) reversed the effect of PAG on the K + ‐induced vasoconstriction in the mouse arterioles and attenuated the K + ‐induced secondary dilatation significantly. Conclusion CSE contributes to the K + ‐induced vasoconstriction via a mechanism involving H 2 S, eNOS, and sGC whereas the secondary dilatation is regulated by eNOS and sGC but not by CSE." @default.
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- W4385684660 date "2023-08-09" @default.
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- W4385684660 title "Inhibition of cystathionine‐gamma lyase dampens vasoconstriction in mouse and human intracerebral arterioles" @default.
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- W4385684660 doi "https://doi.org/10.1111/apha.14021" @default.
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