FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385684908> ?p ?o ?g. }

• W4385684908 endingPage "10" @default.
• W4385684908 startingPage "1" @default.
• W4385684908 abstract "Anorexia nervosa (AN) is characterized by sizable, widespread gray matter (GM) reductions in the acutely underweight state. However, evidence for persistent alterations after weight-restoration has been surprisingly scarce despite high relapse rates, frequent transitions to other psychiatric disorders, and generally unfavorable outcome. While most studies investigated brain regions separately (univariate analysis), psychiatric disorders can be conceptualized as brain network disorders characterized by multivariate alterations with only subtle local effects. We tested for persistent multivariate structural brain alterations in weight-restored individuals with a history of AN, investigated their putative biological substrate and relation with 1-year treatment outcome.We trained machine learning models on regional GM measures to classify healthy controls (HC) (N = 289) from individuals at three stages of AN: underweight patients starting intensive treatment (N = 165, used as baseline), patients after partial weight-restoration (N = 115), and former patients after stable and full weight-restoration (N = 89). Alterations after weight-restoration were related to treatment outcome and characterized both anatomically and functionally.Patients could be classified from HC when underweight (ROC-AUC = 0.90) but also after partial weight-restoration (ROC-AUC = 0.64). Alterations after partial weight-restoration were more pronounced in patients with worse outcome and were not detected in long-term weight-recovered individuals, i.e. those with favorable outcome. These alterations were more pronounced in regions with greater functional connectivity, not merely explained by body mass index, and even increases in cortical thickness were observed (insula, lateral orbitofrontal, temporal pole).Analyzing persistent multivariate brain structural alterations after weight-restoration might help to develop personalized interventions after discharge from inpatient treatment." @default.
• W4385684908 created "2023-08-10" @default.
• W4385684908 creator A5000599118 @default.
• W4385684908 creator A5032133633 @default.
• W4385684908 creator A5048731585 @default.
• W4385684908 creator A5068078898 @default.
• W4385684908 creator A5069229004 @default.
• W4385684908 creator A5082401167 @default.
• W4385684908 creator A5082971911 @default.
• W4385684908 creator A5092617385 @default.
• W4385684908 creator A5092617386 @default.
• W4385684908 date "2023-08-09" @default.
• W4385684908 modified "2023-09-25" @default.
• W4385684908 title "Predicting long-term outcome in anorexia nervosa: a machine learning analysis of brain structure at different stages of weight recovery" @default.
• W4385684908 cites W1947510180 @default.
• W4385684908 cites W1966716734 @default.
• W4385684908 cites W1999653836 @default.
• W4385684908 cites W2009304806 @default.
• W4385684908 cites W2010157103 @default.
• W4385684908 cites W2011402106 @default.
• W4385684908 cites W2014022174 @default.
• W4385684908 cites W2019093320 @default.
• W4385684908 cites W2024699867 @default.
• W4385684908 cites W2093980670 @default.
• W4385684908 cites W2101135654 @default.
• W4385684908 cites W2121027538 @default.
• W4385684908 cites W2141910241 @default.
• W4385684908 cites W2164086669 @default.
• W4385684908 cites W2171781860 @default.
• W4385684908 cites W2273268644 @default.
• W4385684908 cites W2285224414 @default.
• W4385684908 cites W2345881395 @default.
• W4385684908 cites W2397026969 @default.
• W4385684908 cites W2510447297 @default.
• W4385684908 cites W2512950745 @default.
• W4385684908 cites W2546647959 @default.
• W4385684908 cites W2746634570 @default.
• W4385684908 cites W2753858316 @default.
• W4385684908 cites W2765550888 @default.
• W4385684908 cites W2786304541 @default.
• W4385684908 cites W2790158966 @default.
• W4385684908 cites W2803924162 @default.
• W4385684908 cites W2895703609 @default.
• W4385684908 cites W2911964244 @default.
• W4385684908 cites W2945226646 @default.
• W4385684908 cites W2949222200 @default.
• W4385684908 cites W2955979325 @default.
• W4385684908 cites W3016345511 @default.
• W4385684908 cites W3036794215 @default.
• W4385684908 cites W3112557632 @default.
• W4385684908 cites W3127700622 @default.
• W4385684908 cites W3134141558 @default.
• W4385684908 cites W3166434367 @default.
• W4385684908 cites W3173485414 @default.
• W4385684908 cites W3182564124 @default.
• W4385684908 cites W3188985821 @default.
• W4385684908 cites W3196524995 @default.
• W4385684908 cites W4205336487 @default.
• W4385684908 cites W4211243277 @default.
• W4385684908 cites W4220969719 @default.
• W4385684908 cites W4224069788 @default.
• W4385684908 cites W4282023109 @default.
• W4385684908 cites W4377229746 @default.
• W4385684908 cites W911261592 @default.
• W4385684908 doi "https://doi.org/10.1017/s0033291723001861" @default.
• W4385684908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37554008" @default.
• W4385684908 hasPublicationYear "2023" @default.
• W4385684908 type Work @default.
• W4385684908 citedByCount "0" @default.
• W4385684908 crossrefType "journal-article" @default.
• W4385684908 hasAuthorship W4385684908A5000599118 @default.
• W4385684908 hasAuthorship W4385684908A5032133633 @default.
• W4385684908 hasAuthorship W4385684908A5048731585 @default.
• W4385684908 hasAuthorship W4385684908A5068078898 @default.
• W4385684908 hasAuthorship W4385684908A5069229004 @default.
• W4385684908 hasAuthorship W4385684908A5082401167 @default.
• W4385684908 hasAuthorship W4385684908A5082971911 @default.
• W4385684908 hasAuthorship W4385684908A5092617385 @default.
• W4385684908 hasAuthorship W4385684908A5092617386 @default.
• W4385684908 hasBestOaLocation W43856849081 @default.
• W4385684908 hasConcept C118552586 @default.
• W4385684908 hasConcept C119857082 @default.
• W4385684908 hasConcept C126322002 @default.
• W4385684908 hasConcept C144301174 @default.
• W4385684908 hasConcept C147583825 @default.
• W4385684908 hasConcept C15744967 @default.
• W4385684908 hasConcept C161584116 @default.
• W4385684908 hasConcept C169900460 @default.
• W4385684908 hasConcept C2776394216 @default.
• W4385684908 hasConcept C2776559556 @default.
• W4385684908 hasConcept C2777031586 @default.
• W4385684908 hasConcept C2780221984 @default.
• W4385684908 hasConcept C2780320433 @default.
• W4385684908 hasConcept C2780586474 @default.
• W4385684908 hasConcept C2781121325 @default.
• W4385684908 hasConcept C2781195155 @default.
• W4385684908 hasConcept C38180746 @default.
• W4385684908 hasConcept C41008148 @default.

• next