FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385685505> ?p ?o ?g. }

• W4385685505 endingPage "253.01" @default.
• W4385685505 startingPage "253.01" @default.
• W4385685505 abstract "Abstract Licensed SARS-CoV-2 vaccines induce robust systemic immune responses, but mucosal immunity in the respiratory tract in form of secretory immunoglobulin A (IgA) or tissue-resident memory T cells (TRM) is not established. Inducing such front-line immunity by mucosal boosting might reduce the individual risk of breakthrough infections and thereby likely mitigate infection dynamics on population level as well. The following project evaluates preclinical and licensed adenoviral vector (Ad) platforms as mucosal SARS-CoV-2 boosters. We show that nasal instillation of Ad5- and Ad19a-Spike following a systemic DNA or mRNA priming results in strong systemic and mucosal immunity in mice. In contrast to two intramuscular injections with a licensed mRNA vaccine, the mucosal boost with Ad vectors induced CD103 +CD69 +tissue-resident memory CD8 +T cells and high levels of Spike-specific IgA in the respiratory tract as well as an enhanced mucosal neutralization of variants of concern. Moreover, the protective efficacy of the mRNA prime/intranasal Ad5 boost strategy was not inferior to two intramuscular mRNA immunizations. In a more translational approach, we employed Janssen’s Ad26.COV2.S as a mucosal booster delivered by a medical mucosal atomization device after a systemic mRNA prime of mice. Concerning systemic responses, the mucosal boost was similarly immunogenic compared to an intramuscular boost with the same vaccine. However, only a mucosal delivery provoked TRM and IgA in the respiratory tract as well as a robust mucosal neutralization of Omicron variants. In conclusion, a mucosal booster immunization is a promising approach to establish mucosal immunity in addition to systemic responses in an mRNA vaccine-primed population." @default.
• W4385685505 created "2023-08-10" @default.
• W4385685505 creator A5004595481 @default.
• W4385685505 creator A5008740501 @default.
• W4385685505 creator A5013830325 @default.
• W4385685505 creator A5013972886 @default.
• W4385685505 creator A5015543699 @default.
• W4385685505 creator A5019429403 @default.
• W4385685505 creator A5019620317 @default.
• W4385685505 creator A5021635776 @default.
• W4385685505 creator A5026516639 @default.
• W4385685505 creator A5035908530 @default.
• W4385685505 creator A5035991850 @default.
• W4385685505 creator A5036365563 @default.
• W4385685505 creator A5040057977 @default.
• W4385685505 creator A5045333543 @default.
• W4385685505 creator A5046989441 @default.
• W4385685505 creator A5051481020 @default.
• W4385685505 creator A5057069014 @default.
• W4385685505 creator A5058153392 @default.
• W4385685505 creator A5074021024 @default.
• W4385685505 creator A5082627042 @default.
• W4385685505 creator A5086215466 @default.
• W4385685505 creator A5089186770 @default.
• W4385685505 creator A5089303162 @default.
• W4385685505 creator A5092793420 @default.
• W4385685505 date "2023-05-01" @default.
• W4385685505 modified "2023-09-27" @default.
• W4385685505 title "Adenoviral vector vaccines are effective mucosal booster modalities to elevate systemic and establish mucosal immunity against SARS-CoV-2" @default.
• W4385685505 doi "https://doi.org/10.4049/jimmunol.210.supp.253.01" @default.
• W4385685505 hasPublicationYear "2023" @default.
• W4385685505 type Work @default.
• W4385685505 citedByCount "0" @default.
• W4385685505 crossrefType "journal-article" @default.
• W4385685505 hasAuthorship W4385685505A5004595481 @default.
• W4385685505 hasAuthorship W4385685505A5008740501 @default.
• W4385685505 hasAuthorship W4385685505A5013830325 @default.
• W4385685505 hasAuthorship W4385685505A5013972886 @default.
• W4385685505 hasAuthorship W4385685505A5015543699 @default.
• W4385685505 hasAuthorship W4385685505A5019429403 @default.
• W4385685505 hasAuthorship W4385685505A5019620317 @default.
• W4385685505 hasAuthorship W4385685505A5021635776 @default.
• W4385685505 hasAuthorship W4385685505A5026516639 @default.
• W4385685505 hasAuthorship W4385685505A5035908530 @default.
• W4385685505 hasAuthorship W4385685505A5035991850 @default.
• W4385685505 hasAuthorship W4385685505A5036365563 @default.
• W4385685505 hasAuthorship W4385685505A5040057977 @default.
• W4385685505 hasAuthorship W4385685505A5045333543 @default.
• W4385685505 hasAuthorship W4385685505A5046989441 @default.
• W4385685505 hasAuthorship W4385685505A5051481020 @default.
• W4385685505 hasAuthorship W4385685505A5057069014 @default.
• W4385685505 hasAuthorship W4385685505A5058153392 @default.
• W4385685505 hasAuthorship W4385685505A5074021024 @default.
• W4385685505 hasAuthorship W4385685505A5082627042 @default.
• W4385685505 hasAuthorship W4385685505A5086215466 @default.
• W4385685505 hasAuthorship W4385685505A5089186770 @default.
• W4385685505 hasAuthorship W4385685505A5089303162 @default.
• W4385685505 hasAuthorship W4385685505A5092793420 @default.
• W4385685505 hasConcept C100701293 @default.
• W4385685505 hasConcept C12590561 @default.
• W4385685505 hasConcept C159047783 @default.
• W4385685505 hasConcept C159654299 @default.
• W4385685505 hasConcept C203014093 @default.
• W4385685505 hasConcept C2779341262 @default.
• W4385685505 hasConcept C2780801004 @default.
• W4385685505 hasConcept C3018462044 @default.
• W4385685505 hasConcept C59822182 @default.
• W4385685505 hasConcept C71924100 @default.
• W4385685505 hasConcept C81444415 @default.
• W4385685505 hasConcept C86803240 @default.
• W4385685505 hasConcept C8891405 @default.
• W4385685505 hasConceptScore W4385685505C100701293 @default.
• W4385685505 hasConceptScore W4385685505C12590561 @default.
• W4385685505 hasConceptScore W4385685505C159047783 @default.
• W4385685505 hasConceptScore W4385685505C159654299 @default.
• W4385685505 hasConceptScore W4385685505C203014093 @default.
• W4385685505 hasConceptScore W4385685505C2779341262 @default.
• W4385685505 hasConceptScore W4385685505C2780801004 @default.
• W4385685505 hasConceptScore W4385685505C3018462044 @default.
• W4385685505 hasConceptScore W4385685505C59822182 @default.
• W4385685505 hasConceptScore W4385685505C71924100 @default.
• W4385685505 hasConceptScore W4385685505C81444415 @default.
• W4385685505 hasConceptScore W4385685505C86803240 @default.
• W4385685505 hasConceptScore W4385685505C8891405 @default.
• W4385685505 hasIssue "1_Supplement" @default.
• W4385685505 hasLocation W43856855051 @default.
• W4385685505 hasOpenAccess W4385685505 @default.
• W4385685505 hasPrimaryLocation W43856855051 @default.
• W4385685505 hasRelatedWork W1794473860 @default.
• W4385685505 hasRelatedWork W1891584141 @default.
• W4385685505 hasRelatedWork W2017835421 @default.
• W4385685505 hasRelatedWork W2044625590 @default.
• W4385685505 hasRelatedWork W2057948995 @default.
• W4385685505 hasRelatedWork W2062945232 @default.
• W4385685505 hasRelatedWork W2383184510 @default.
• W4385685505 hasRelatedWork W3017822181 @default.
• W4385685505 hasRelatedWork W3032210197 @default.
• W4385685505 hasRelatedWork W573847062 @default.

• next