Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385685951> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W4385685951 endingPage "223.06" @default.
- W4385685951 startingPage "223.06" @default.
- W4385685951 abstract "Abstract Candidaspecies are the leading cause of life-threatening fungal infections in humans, especially among immunocompromised and hospitalized individuals. Of utmost concern is the emerging “superbug” Candida auriswhich has the potential to disseminate into bloodstream infections with up to 60% mortality in susceptible populations. Importantly, C. aurisis the first inherently multidrug-resistant fungal pathogen, which contributes to a delay in effective treatment and increased mortality rates. Consequently, C. aurisis the first fungal pathogen to cause a serious global public health threat. Our lab has identified and isolated a panel of universal monoclonal antibodies (mAbs) specific to Candidacell wall epitopes that share high homology among various human pathogenic Candidaspecies. Using an established murine model of disseminated infection, we showed that passive transfer of mAb C3.1 (anti-β-1,2-mannotriose) significantly extended survival and reduced fungal burdens and inflammation during early infection. We also showed that mAbs C3.1 and 9F2 (anti-phosphoglycerate kinase 1) significantly enhanced phagocytosis of C. aurisyeast by macrophages and inhibited the proliferation of multiple C. aurisclinical isolates in vitro. Since there are currently no approved antifungal vaccines or antibodies and current treatments are inadequate, critically needed antifungal antibodies can provide long-awaited effective therapies against this deadly pathogen. Our future directions include developing humanized mAbs to evaluate their protective efficacy in genetic mouse models of human immunodeficiency. We will then utilize Fc engineering to derive human IgG1 variants for enhanced complement-based effector efficacy. Supported by grants from NIH /NIAID (R21AI168929) and the Department of Defense (PR171482)" @default.
- W4385685951 created "2023-08-10" @default.
- W4385685951 creator A5009197907 @default.
- W4385685951 creator A5037415126 @default.
- W4385685951 creator A5087321855 @default.
- W4385685951 date "2023-05-01" @default.
- W4385685951 modified "2023-10-02" @default.
- W4385685951 title "Universal <i>Candida</i>cell-surface-specific monoclonal antibodies protect mice against multidrug-resistant <i>Candida auris</i>bloodstream infections" @default.
- W4385685951 doi "https://doi.org/10.4049/jimmunol.210.supp.223.06" @default.
- W4385685951 hasPublicationYear "2023" @default.
- W4385685951 type Work @default.
- W4385685951 citedByCount "0" @default.
- W4385685951 crossrefType "journal-article" @default.
- W4385685951 hasAuthorship W4385685951A5009197907 @default.
- W4385685951 hasAuthorship W4385685951A5037415126 @default.
- W4385685951 hasAuthorship W4385685951A5087321855 @default.
- W4385685951 hasBestOaLocation W43856859511 @default.
- W4385685951 hasConcept C159047783 @default.
- W4385685951 hasConcept C159654299 @default.
- W4385685951 hasConcept C195616568 @default.
- W4385685951 hasConcept C203014093 @default.
- W4385685951 hasConcept C24527192 @default.
- W4385685951 hasConcept C2776460866 @default.
- W4385685951 hasConcept C2778502174 @default.
- W4385685951 hasConcept C2779548794 @default.
- W4385685951 hasConcept C2909786013 @default.
- W4385685951 hasConcept C523546767 @default.
- W4385685951 hasConcept C542903549 @default.
- W4385685951 hasConcept C54355233 @default.
- W4385685951 hasConcept C86803240 @default.
- W4385685951 hasConcept C89423630 @default.
- W4385685951 hasConceptScore W4385685951C159047783 @default.
- W4385685951 hasConceptScore W4385685951C159654299 @default.
- W4385685951 hasConceptScore W4385685951C195616568 @default.
- W4385685951 hasConceptScore W4385685951C203014093 @default.
- W4385685951 hasConceptScore W4385685951C24527192 @default.
- W4385685951 hasConceptScore W4385685951C2776460866 @default.
- W4385685951 hasConceptScore W4385685951C2778502174 @default.
- W4385685951 hasConceptScore W4385685951C2779548794 @default.
- W4385685951 hasConceptScore W4385685951C2909786013 @default.
- W4385685951 hasConceptScore W4385685951C523546767 @default.
- W4385685951 hasConceptScore W4385685951C542903549 @default.
- W4385685951 hasConceptScore W4385685951C54355233 @default.
- W4385685951 hasConceptScore W4385685951C86803240 @default.
- W4385685951 hasConceptScore W4385685951C89423630 @default.
- W4385685951 hasIssue "1_Supplement" @default.
- W4385685951 hasLocation W43856859511 @default.
- W4385685951 hasOpenAccess W4385685951 @default.
- W4385685951 hasPrimaryLocation W43856859511 @default.
- W4385685951 hasRelatedWork W1975565982 @default.
- W4385685951 hasRelatedWork W1992612426 @default.
- W4385685951 hasRelatedWork W2047670885 @default.
- W4385685951 hasRelatedWork W2051909045 @default.
- W4385685951 hasRelatedWork W2085675226 @default.
- W4385685951 hasRelatedWork W2101049085 @default.
- W4385685951 hasRelatedWork W2106670663 @default.
- W4385685951 hasRelatedWork W2126011181 @default.
- W4385685951 hasRelatedWork W3210255874 @default.
- W4385685951 hasRelatedWork W4226177362 @default.
- W4385685951 hasVolume "210" @default.
- W4385685951 isParatext "false" @default.
- W4385685951 isRetracted "false" @default.
- W4385685951 workType "article" @default.