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- W4385686502 abstract "Abstract Sjögren’s disease is a chronic autoimmune disease characterized by focal inflammation of the lacrimal and salivary glands. NOD mice spontaneously develop lacrimal gland inflammation by 5–6 weeks. As disease progresses, B cells accumulate in the glands and produce antibodies resulting in glandular dysfunction. Disruption of the type I interferon (IFN) signaling pathway protects NOD mice from developing lacrimal gland disease. While the impact of B cells later in disease has been well-characterized, the role of B cells in early disease development has not been defined. Here, we performed gene expression studies, adoptive transfers, and spectral flow cytometry to define the phenotype of B cell subsets and the potential role of type I IFN signaling in lacrimal gland autoimmunity. Gene expression studies demonstrated that genes associated with B cell receptor signaling, lymphocyte trafficking and antigen presentation were upregulated at 10 weeks compared to 6 weeks. Flow cytometry of the lacrimal glands showed that most early B cells express IFNAR1. Adoptive transfer studies demonstrated decreased disease when donor cells lacked IFNAR1 expression compared to WT donor cells, but this difference was abrogated when magnetically purified T cells were transferred suggesting a type I IFN dependent pathogenic role on a non-T cell population. In vitro studies show that B cell phenotype can be shaped by IFNα in a dose dependent manner. Type l IFN signaling drives the development of lacrimal gland autoimmunity in NOD mice. Type l IFN signaling shapes B cell phenotype and function in early lacrimal gland disease. Ongoing in vivo studies will interrogate the impact of IFNAR1 expression on B cell trafficking to the lacrimal glands. Supported by grants from NIH (R01 EY027731)" @default.
- W4385686502 created "2023-08-10" @default.
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- W4385686502 date "2023-05-01" @default.
- W4385686502 modified "2023-09-27" @default.
- W4385686502 title "Impact of type I IFN signaling on B cell pathogenicity in a mouse model of early Sjögren’s disease" @default.
- W4385686502 doi "https://doi.org/10.4049/jimmunol.210.supp.247.02" @default.
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