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- W4385687557 abstract "Abstract Endometrial cancer (EC) is the most common cancer diagnosis of the reproductive organs among women in the United States. Previous studies have shown the chemokine CXCL13 was correlated with forming B-cell and other immune cell aggregates in the presence of high endothelial venules (HEV). These ectopic lymphoid formations are referred to as tertiary lymphoid structures (TLS). Some studies have shown that TLS are associated with a reduced risk of recurrence and improved immune response in cancers, while others have described negative cancer outcomes associated with TLS. Few studies have focused on the role of TLS in EC and the pathways involved in tumorigenesis. In this project, we identify chemokine-mediated gene networks associated with TLS formation and EC pathogenicity. We obtained RNA-Seq EC samples (n=643), which included Type I Uterine Corpus Endometrial Cancer (UCEC, n=587) and Type II Uterine Carcinosarcoma (UCS, n= 56) from the Cancer Genome Atlas (TCGA). Hierarchically clustered genes were correlated, functionally annotated for mRNA, and evaluated using a weighted gene network co-expression analysis (WGCNA). Functional enrichment analysis, such as Gene Ontology (GO) and the database for annotation, visualization, and integrated discovery (DAVID), were used to identify and visualize biological functions associated with the hub genes overrepresented in significant modules. Modules associated with metastasis and survival are representative of novel and known pathways. The analysis reveals that CXCL13 may be involved in cell cycle progression and apoptosis pathways. This study provides novel insights into the biological pathways associated with TLS, EC tumorigenesis, and patient survival risks. Supported by Frederick National Laboratory for Cancer Research subcontract IDIQ NCI (75N91019D00024) and MSM/TU/UABCCC Partnership NCI (U54CA118638)" @default.
- W4385687557 created "2023-08-10" @default.
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- W4385687557 date "2023-05-01" @default.
- W4385687557 modified "2023-09-27" @default.
- W4385687557 title "Gene co-expression regulatory analysis associated with tertiary lymphoid structures and endometrial cancer progression" @default.
- W4385687557 doi "https://doi.org/10.4049/jimmunol.210.supp.144.01" @default.
- W4385687557 hasPublicationYear "2023" @default.
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