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- W4385687612 abstract "Abstract Atopic dermatitis results in profound changes in the function of the skin that include diminished barrier function and altered production of antimicrobial peptides. Dendritic epidermal γδ T cells (DETC) are a subset of γδ T cells that play an important role in the wound repair and inflammation process. Our previous work identified a loss of DETC in Stat6VT mice and in MC903 induced skin inflammation mouse model that was dependent on IL-4. However, the mechanisms through which IL-4 mediates this loss of DETCs are still not clear. In this study, we show that IL-4Rα germline knockout mice (Il4ra−/−) have an increased DETC population in skin that correlates with a higher rate of wound closure and increased EDC gene and fibronectin 1 expression. In Il4ra−/− mice, MC903 induced loss of DETCs was alleviated. Bone marrow chimeras of Il4ra−/− and WT bone marrow into Il4ra−/− mice retained the increased DETCs in the skin of Il4ra−/− host mice. Importantly, IL-15 secretion from skin keratinocytes was decreased dramatically in the MC903 induced skin inflammation model and injection of IL-15 rescued the loss of DETCs. Furthermore, conditional knock out of IL-4Rα from Keratinocytes of Il4ra fl/fl K14cre mice also showed an increase of this DETC populations in skin, increased IL-15 expression and less skin inflammation. Together, these results identify an IL-4-dependent circuit that regulates DETCs in the skin by repressing IL-15 expression in keratinocytes. This provides further insights into the ability of IL-4 to promote the development of atopic lesions and impair wound healing. Supported by grants from NIH (R01AI095282)" @default.
- W4385687612 created "2023-08-10" @default.
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- W4385687612 date "2023-05-01" @default.
- W4385687612 modified "2023-09-27" @default.
- W4385687612 title "Diminished γδ T Cells during allergic skin inflammation is mediated by IL-4 signaling in keratinocytes" @default.
- W4385687612 doi "https://doi.org/10.4049/jimmunol.210.supp.60.10" @default.
- W4385687612 hasPublicationYear "2023" @default.
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