Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385687788> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4385687788 endingPage "251.19" @default.
- W4385687788 startingPage "251.19" @default.
- W4385687788 abstract "Abstract The emergence of new virus species or variants poses a major challenge for healthcare systems. Countermeasures, including vaccine development, need to be developed without delay to ensure success. Vaccine and antibody development depend on highly efficient tools for antigen discovery, epitope mapping, diagnostics and (clinical) immune monitoring. Here we present a workflow for peptide tool development that can be rapidly adapted to emerging viruses. It combines bioinformatics algorithms and an ultra-high throughput peptide synthesis method alongside high-content assay formats. Data from different SARS-CoV-2 studies are presented addressing elucidation of both cellular and humoral immune responses. Robust spike-specific cellular immune responses were measured using SARS-CoV-2 Spike PepMix ™peptide pools during infection and/or vaccine response monitoring [ 1]. Using epitope mapping (matrix) pools an immunodominant T-cell epitope was identified that may contribute to the optimization of existing vaccines [ 2]. In addition, the immune response of Covid-19 convalescents against all major SARS-CoV-2 proteins was analyzed [ 2]. Humoral immune response analysis by high-density peptide microarrays identified immunodominant B cell epitopes as starting points for the development of alternative vaccines and diagnostic tests [ 3]. In conclusion, we show that readily available and tailored peptide formats, as exemplified for SARS-CoV-2, are important tools that contribute to the fast development and optimization of vaccines and diagnostic tests for emerging viruses of concern." @default.
- W4385687788 created "2023-08-10" @default.
- W4385687788 creator A5000440510 @default.
- W4385687788 creator A5002184305 @default.
- W4385687788 creator A5005123728 @default.
- W4385687788 creator A5033824960 @default.
- W4385687788 creator A5035617308 @default.
- W4385687788 creator A5042875555 @default.
- W4385687788 creator A5060408559 @default.
- W4385687788 creator A5061622309 @default.
- W4385687788 creator A5063669702 @default.
- W4385687788 creator A5068836059 @default.
- W4385687788 creator A5075692819 @default.
- W4385687788 creator A5088948702 @default.
- W4385687788 date "2023-05-01" @default.
- W4385687788 modified "2023-09-27" @default.
- W4385687788 title "Fast Preparation of Peptide Tools to address new emerging Viruses: Case example SARS-CoV-2" @default.
- W4385687788 cites W3148747206 @default.
- W4385687788 cites W3197781442 @default.
- W4385687788 doi "https://doi.org/10.4049/jimmunol.210.supp.251.19" @default.
- W4385687788 hasPublicationYear "2023" @default.
- W4385687788 type Work @default.
- W4385687788 citedByCount "0" @default.
- W4385687788 crossrefType "journal-article" @default.
- W4385687788 hasAuthorship W4385687788A5000440510 @default.
- W4385687788 hasAuthorship W4385687788A5002184305 @default.
- W4385687788 hasAuthorship W4385687788A5005123728 @default.
- W4385687788 hasAuthorship W4385687788A5033824960 @default.
- W4385687788 hasAuthorship W4385687788A5035617308 @default.
- W4385687788 hasAuthorship W4385687788A5042875555 @default.
- W4385687788 hasAuthorship W4385687788A5060408559 @default.
- W4385687788 hasAuthorship W4385687788A5061622309 @default.
- W4385687788 hasAuthorship W4385687788A5063669702 @default.
- W4385687788 hasAuthorship W4385687788A5068836059 @default.
- W4385687788 hasAuthorship W4385687788A5075692819 @default.
- W4385687788 hasAuthorship W4385687788A5088948702 @default.
- W4385687788 hasBestOaLocation W43856877881 @default.
- W4385687788 hasConcept C142724271 @default.
- W4385687788 hasConcept C147483822 @default.
- W4385687788 hasConcept C159047783 @default.
- W4385687788 hasConcept C195616568 @default.
- W4385687788 hasConcept C203014093 @default.
- W4385687788 hasConcept C2779134260 @default.
- W4385687788 hasConcept C2781241564 @default.
- W4385687788 hasConcept C3007834351 @default.
- W4385687788 hasConcept C3008058167 @default.
- W4385687788 hasConcept C524204448 @default.
- W4385687788 hasConcept C70721500 @default.
- W4385687788 hasConcept C71924100 @default.
- W4385687788 hasConcept C86803240 @default.
- W4385687788 hasConcept C8891405 @default.
- W4385687788 hasConceptScore W4385687788C142724271 @default.
- W4385687788 hasConceptScore W4385687788C147483822 @default.
- W4385687788 hasConceptScore W4385687788C159047783 @default.
- W4385687788 hasConceptScore W4385687788C195616568 @default.
- W4385687788 hasConceptScore W4385687788C203014093 @default.
- W4385687788 hasConceptScore W4385687788C2779134260 @default.
- W4385687788 hasConceptScore W4385687788C2781241564 @default.
- W4385687788 hasConceptScore W4385687788C3007834351 @default.
- W4385687788 hasConceptScore W4385687788C3008058167 @default.
- W4385687788 hasConceptScore W4385687788C524204448 @default.
- W4385687788 hasConceptScore W4385687788C70721500 @default.
- W4385687788 hasConceptScore W4385687788C71924100 @default.
- W4385687788 hasConceptScore W4385687788C86803240 @default.
- W4385687788 hasConceptScore W4385687788C8891405 @default.
- W4385687788 hasIssue "1_Supplement" @default.
- W4385687788 hasLocation W43856877881 @default.
- W4385687788 hasOpenAccess W4385687788 @default.
- W4385687788 hasPrimaryLocation W43856877881 @default.
- W4385687788 hasRelatedWork W1755417734 @default.
- W4385687788 hasRelatedWork W1984328279 @default.
- W4385687788 hasRelatedWork W2047670885 @default.
- W4385687788 hasRelatedWork W2070508846 @default.
- W4385687788 hasRelatedWork W2162061613 @default.
- W4385687788 hasRelatedWork W2220102944 @default.
- W4385687788 hasRelatedWork W2800235700 @default.
- W4385687788 hasRelatedWork W2904577393 @default.
- W4385687788 hasRelatedWork W3030353419 @default.
- W4385687788 hasRelatedWork W4226177362 @default.
- W4385687788 hasVolume "210" @default.
- W4385687788 isParatext "false" @default.
- W4385687788 isRetracted "false" @default.
- W4385687788 workType "article" @default.