Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385688849> ?p ?o ?g. }
- W4385688849 endingPage "5034" @default.
- W4385688849 startingPage "5018" @default.
- W4385688849 abstract "Natural products and their derivatives are widely used across various industries, particularly pharmaceuticals. Modern engineered biosynthesis provides an alternative way of producing and meeting the growing need for diverse natural products. Natural enzymes, on the other hand, often exhibit unsatisfactory catalytic characteristics and necessitate further enzyme engineering modifications. QM/MM, as a powerful and extensively used computational tool in the field of enzyme catalysis, has been increasingly applied in rational enzyme engineering over the past decade. In this review, we summarize recent advances in QM/MM computational investigation on enzyme catalysis and enzyme engineering for natural product biosynthesis. The challenges and perspectives for future QM/MM applications aided enzyme engineering in natural product biosynthesis will also be discussed." @default.
- W4385688849 created "2023-08-10" @default.
- W4385688849 creator A5012066268 @default.
- W4385688849 creator A5053447705 @default.
- W4385688849 creator A5090084906 @default.
- W4385688849 date "2023-08-09" @default.
- W4385688849 modified "2023-10-10" @default.
- W4385688849 title "QM/MM Modeling Aided Enzyme Engineering in Natural Products Biosynthesis" @default.
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