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• W4385689311 startingPage "112958" @default.
• W4385689311 abstract "Chromatin accessibility fundamentally governs gene expression and biological response programs that can be manipulated by pathogens. Here we capture dynamic chromatin landscapes of individual B cells during Epstein-Barr virus (EBV) infection. EBV+ cells that exhibit arrest via antiviral sensing and proliferation-linked DNA damage experience global accessibility reduction. Proliferative EBV+ cells develop expression-linked architectures and motif accessibility profiles resembling in vivo germinal center (GC) phenotypes. Remarkably, EBV elicits dark zone (DZ), light zone (LZ), and post-GC B cell chromatin features despite BCL6 downregulation. Integration of single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq), single-cell RNA sequencing (scRNA-seq), and chromatin immunoprecipitation sequencing (ChIP-seq) data enables genome-wide cis-regulatory predictions implicating EBV nuclear antigens (EBNAs) in phenotype-specific control of GC B cell activation, survival, and immune evasion. Knockouts validate bioinformatically identified regulators (MEF2C and NFE2L2) of EBV-induced GC phenotypes and EBNA-associated loci that regulate gene expression (CD274/PD-L1). These data and methods can inform high-resolution investigations of EBV-host interactions, B cell fates, and virus-mediated lymphomagenesis." @default.
• W4385689311 created "2023-08-10" @default.
• W4385689311 creator A5011307478 @default.
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• W4385689311 creator A5066575551 @default.
• W4385689311 creator A5074708582 @default.
• W4385689311 creator A5084068646 @default.
• W4385689311 date "2023-08-01" @default.
• W4385689311 modified "2023-10-11" @default.
• W4385689311 title "Epstein-Barr virus evades restrictive host chromatin closure by subverting B cell activation and germinal center regulatory loci" @default.
• W4385689311 cites W1487941441 @default.
• W4385689311 cites W1491749295 @default.
• W4385689311 cites W1492083415 @default.
• W4385689311 cites W1529933123 @default.
• W4385689311 cites W1544117098 @default.
• W4385689311 cites W1573924111 @default.
• W4385689311 cites W1602702667 @default.
• W4385689311 cites W1614256433 @default.
• W4385689311 cites W1896063886 @default.
• W4385689311 cites W1965530946 @default.
• W4385689311 cites W1969533728 @default.
• W4385689311 cites W1973062929 @default.
• W4385689311 cites W1975200363 @default.
• W4385689311 cites W1978032326 @default.
• W4385689311 cites W1979594866 @default.
• W4385689311 cites W1984883254 @default.
• W4385689311 cites W1986432884 @default.
• W4385689311 cites W1990232520 @default.
• W4385689311 cites W2001353514 @default.
• W4385689311 cites W2003641968 @default.
• W4385689311 cites W2005389118 @default.
• W4385689311 cites W2021341670 @default.
• W4385689311 cites W2025042617 @default.
• W4385689311 cites W2025451399 @default.
• W4385689311 cites W2025772032 @default.
• W4385689311 cites W2026908402 @default.
• W4385689311 cites W2030277211 @default.
• W4385689311 cites W2033106764 @default.
• W4385689311 cites W2035585065 @default.
• W4385689311 cites W2035618305 @default.
• W4385689311 cites W2036217549 @default.
• W4385689311 cites W2036321243 @default.
• W4385689311 cites W2045120099 @default.
• W4385689311 cites W2045939728 @default.
• W4385689311 cites W2046635524 @default.
• W4385689311 cites W2050672588 @default.
• W4385689311 cites W2054076276 @default.
• W4385689311 cites W2066211653 @default.
• W4385689311 cites W2069089843 @default.
• W4385689311 cites W2071775939 @default.
• W4385689311 cites W2072478189 @default.
• W4385689311 cites W2076066232 @default.
• W4385689311 cites W2076226859 @default.
• W4385689311 cites W2078184757 @default.
• W4385689311 cites W2080385928 @default.
• W4385689311 cites W2082364381 @default.
• W4385689311 cites W2089219418 @default.
• W4385689311 cites W2092205091 @default.
• W4385689311 cites W2092869829 @default.
• W4385689311 cites W2096271770 @default.
• W4385689311 cites W2096745936 @default.
• W4385689311 cites W2102212449 @default.
• W4385689311 cites W2102619694 @default.
• W4385689311 cites W2107244203 @default.
• W4385689311 cites W2107680358 @default.
• W4385689311 cites W2109838603 @default.
• W4385689311 cites W2110768394 @default.
• W4385689311 cites W2111789241 @default.
• W4385689311 cites W2116173775 @default.
• W4385689311 cites W2117757143 @default.
• W4385689311 cites W2122295508 @default.
• W4385689311 cites W2130278093 @default.
• W4385689311 cites W2130744509 @default.
• W4385689311 cites W2135144687 @default.
• W4385689311 cites W2136952715 @default.
• W4385689311 cites W2138364237 @default.
• W4385689311 cites W2139387072 @default.
• W4385689311 cites W2140282206 @default.
• W4385689311 cites W2144490703 @default.
• W4385689311 cites W2146471452 @default.
• W4385689311 cites W2147530365 @default.
• W4385689311 cites W2152716989 @default.
• W4385689311 cites W2157037109 @default.
• W4385689311 cites W2159675211 @default.
• W4385689311 cites W2160487610 @default.
• W4385689311 cites W2165042359 @default.
• W4385689311 cites W2166823073 @default.
• W4385689311 cites W2178888844 @default.
• W4385689311 cites W2259398295 @default.
• W4385689311 cites W2259938310 @default.
• W4385689311 cites W2278293665 @default.
• W4385689311 cites W2338055556 @default.
• W4385689311 cites W2349842709 @default.
• W4385689311 cites W2403341971 @default.
• W4385689311 cites W2493763501 @default.
• W4385689311 cites W2583285089 @default.
• W4385689311 cites W2605956581 @default.

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