Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385691093> ?p ?o ?g. }
- W4385691093 endingPage "797" @default.
- W4385691093 startingPage "787" @default.
- W4385691093 abstract "Stroke is one of the principal cerebrovascular diseases in human populations and contributes to a majority of the functional impairments in the elderly. Recent discoveries have led to the inclusion of electroencephalography (EEG) in the complementary prognostic evaluation of patients. The present study describes the EEG, behavioral, and histological changes that occur following cerebral ischemia associated with treatment by G1, a potent and selective G protein-coupled estrogen receptor 1 (GPER1) agonist in a rat model. Treatment with G1 attenuated the neurological deficits induced by ischemic stroke from the second day onward, and reduced areas of infarction. Treatment with G1 also improved the total brainwave power, as well as the theta and alpha wave activity, specifically, and restored the delta band power to levels similar to those observed in the controls. Treatment with G1 also attenuated the peaks of harmful activity observed in the EEG indices. These improvements in brainwave activity indicate that GPER1 plays a fundamental role in the mediation of cerebral injury and in the behavioral outcome of ischemic brain injuries, which points to treatment with G1 as a potential pharmacological strategy for the therapy of stroke." @default.
- W4385691093 created "2023-08-10" @default.
- W4385691093 creator A5004050243 @default.
- W4385691093 creator A5020842186 @default.
- W4385691093 creator A5032525314 @default.
- W4385691093 creator A5047929834 @default.
- W4385691093 creator A5077152011 @default.
- W4385691093 creator A5078397160 @default.
- W4385691093 creator A5082363468 @default.
- W4385691093 creator A5082942543 @default.
- W4385691093 creator A5087252843 @default.
- W4385691093 date "2023-08-21" @default.
- W4385691093 modified "2023-10-17" @default.
- W4385691093 title "The GPER1 agonist G1 reduces brain injury and improves the qEEG and behavioral outcome of experimental ischemic stroke" @default.
- W4385691093 cites W1852128587 @default.
- W4385691093 cites W1877876694 @default.
- W4385691093 cites W1906069397 @default.
- W4385691093 cites W1963671300 @default.
- W4385691093 cites W1965268009 @default.
- W4385691093 cites W1966635399 @default.
- W4385691093 cites W1970146816 @default.
- W4385691093 cites W1978159555 @default.
- W4385691093 cites W1981467972 @default.
- W4385691093 cites W1984479644 @default.
- W4385691093 cites W1990577295 @default.
- W4385691093 cites W2005078985 @default.
- W4385691093 cites W2005737926 @default.
- W4385691093 cites W2010674238 @default.
- W4385691093 cites W2014006430 @default.
- W4385691093 cites W2021733490 @default.
- W4385691093 cites W2024782388 @default.
- W4385691093 cites W2030313584 @default.
- W4385691093 cites W2036648234 @default.
- W4385691093 cites W2038412573 @default.
- W4385691093 cites W2058349530 @default.
- W4385691093 cites W2071665210 @default.
- W4385691093 cites W2079136723 @default.
- W4385691093 cites W2081144582 @default.
- W4385691093 cites W2090014459 @default.
- W4385691093 cites W2103944014 @default.
- W4385691093 cites W2116647813 @default.
- W4385691093 cites W2123476163 @default.
- W4385691093 cites W2137010838 @default.
- W4385691093 cites W2137207319 @default.
- W4385691093 cites W2305657988 @default.
- W4385691093 cites W2337735554 @default.
- W4385691093 cites W2414584648 @default.
- W4385691093 cites W2614629764 @default.
- W4385691093 cites W2741093459 @default.
- W4385691093 cites W2762292687 @default.
- W4385691093 cites W2879097257 @default.
- W4385691093 cites W2890127711 @default.
- W4385691093 cites W2969629410 @default.
- W4385691093 cites W2972507530 @default.
- W4385691093 cites W2990283276 @default.
- W4385691093 cites W3003299879 @default.
- W4385691093 cites W3009731615 @default.
- W4385691093 cites W3016510909 @default.
- W4385691093 cites W3094029004 @default.
- W4385691093 cites W3107425428 @default.
- W4385691093 cites W3113239986 @default.
- W4385691093 cites W3145150059 @default.
- W4385691093 cites W4323317296 @default.
- W4385691093 cites W968071110 @default.
- W4385691093 doi "https://doi.org/10.1093/jnen/nlad061" @default.
- W4385691093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37558387" @default.
- W4385691093 hasPublicationYear "2023" @default.
- W4385691093 type Work @default.
- W4385691093 citedByCount "0" @default.
- W4385691093 crossrefType "journal-article" @default.
- W4385691093 hasAuthorship W4385691093A5004050243 @default.
- W4385691093 hasAuthorship W4385691093A5020842186 @default.
- W4385691093 hasAuthorship W4385691093A5032525314 @default.
- W4385691093 hasAuthorship W4385691093A5047929834 @default.
- W4385691093 hasAuthorship W4385691093A5077152011 @default.
- W4385691093 hasAuthorship W4385691093A5078397160 @default.
- W4385691093 hasAuthorship W4385691093A5082363468 @default.
- W4385691093 hasAuthorship W4385691093A5082942543 @default.
- W4385691093 hasAuthorship W4385691093A5087252843 @default.
- W4385691093 hasConcept C126322002 @default.
- W4385691093 hasConcept C127413603 @default.
- W4385691093 hasConcept C15744967 @default.
- W4385691093 hasConcept C164705383 @default.
- W4385691093 hasConcept C169760540 @default.
- W4385691093 hasConcept C170493617 @default.
- W4385691093 hasConcept C2778820722 @default.
- W4385691093 hasConcept C2778938600 @default.
- W4385691093 hasConcept C2779450755 @default.
- W4385691093 hasConcept C2780645631 @default.
- W4385691093 hasConcept C522805319 @default.
- W4385691093 hasConcept C541997718 @default.
- W4385691093 hasConcept C71924100 @default.
- W4385691093 hasConcept C78519656 @default.
- W4385691093 hasConceptScore W4385691093C126322002 @default.
- W4385691093 hasConceptScore W4385691093C127413603 @default.
- W4385691093 hasConceptScore W4385691093C15744967 @default.
- W4385691093 hasConceptScore W4385691093C164705383 @default.
- W4385691093 hasConceptScore W4385691093C169760540 @default.