FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385691130> ?p ?o ?g. }

• W4385691130 endingPage "117021" @default.
• W4385691130 startingPage "117021" @default.
• W4385691130 abstract "The P. pinaster species, known as 'Pino nigral or rodeno', is used in the treatment of colds, asthma, flu, and tuberculosis.This study determined the anti-inflammatory, analgesic, and antibacterial activities of the P. pinaster resin, identifying the compounds with higher biological activity.A bio-guided isolation of the compounds of P. pinaster was carried out by selecting the most active extracts with anti-inflammatory and analgesic effects in the HBEC3-KT, MRC-5, and THP-1 cell lines. The antibacterial activity was determined against the S. aureus, S. pneumoniae, K. pneumoniae and P. aeruginosa strains.The following compounds were identified by NMR: dehydroabietic acid (1), ( + )-cis-abienol (2), pimaric acid (3), isopimaric acid (4), 7α-hydroxy-dehydroabietic acid (5), 7-oxo-dehydroabietic acid (6), 15-hydroxy-abietic acid (7), 7-oxo-15-hydroxy-dehydroabietic acid (8), 13-oxo-8 (14)-podocarpen-18-oic acid (9), and pinyunin A (10). Regarding their anti-inflammatory activity, all compounds inhibited NF-κB. Compound 9 was the most active (IC50 = 3.90-12.06 μM). Concerning the analgesic activity, all the compounds inhibited NK-1, yet compound 9 was the most active (IC50 = 0.28-0.33 μM). Finally, compounds 6 (MIC = 12.80-25.55 μM) and 9 (MIC = 9.80-24.31 μM) were the most promising antibacterial compounds in all strains.This study managed to identify, for the first time, six diterpenes from the resin of P. pinaster, with anti-inflammatory, analgesic, and antibacterial activity. Among the identified compounds, compound 9 was the most active, being considered a promising candidate as an antagonist of the tachykinin NK-1 receptor and as an analgesic agent against inflammation and neuropathic pain. It also had an antibacterial effect against Gram negative bacteria." @default.
• W4385691130 created "2023-08-10" @default.
• W4385691130 creator A5021006904 @default.
• W4385691130 creator A5049592664 @default.
• W4385691130 creator A5050058253 @default.
• W4385691130 creator A5084968904 @default.
• W4385691130 date "2024-01-01" @default.
• W4385691130 modified "2023-10-02" @default.
• W4385691130 title "Diterpenes of Pinus pinaster aiton with anti-inflammatory, analgesic, and antibacterial activities" @default.
• W4385691130 cites W1467227077 @default.
• W4385691130 cites W1573556272 @default.
• W4385691130 cites W1837911080 @default.
• W4385691130 cites W1968267256 @default.
• W4385691130 cites W1971440330 @default.
• W4385691130 cites W1983304097 @default.
• W4385691130 cites W1985828787 @default.
• W4385691130 cites W1993891111 @default.
• W4385691130 cites W1994921065 @default.
• W4385691130 cites W1997527480 @default.
• W4385691130 cites W2000598775 @default.
• W4385691130 cites W2005785799 @default.
• W4385691130 cites W2009012246 @default.
• W4385691130 cites W2026424650 @default.
• W4385691130 cites W2030066083 @default.
• W4385691130 cites W2030866854 @default.
• W4385691130 cites W2036638510 @default.
• W4385691130 cites W2041809269 @default.
• W4385691130 cites W2047752978 @default.
• W4385691130 cites W2049992081 @default.
• W4385691130 cites W2059733918 @default.
• W4385691130 cites W2063793826 @default.
• W4385691130 cites W2065329588 @default.
• W4385691130 cites W2073409589 @default.
• W4385691130 cites W2144706975 @default.
• W4385691130 cites W2148440503 @default.
• W4385691130 cites W2156573769 @default.
• W4385691130 cites W2171092798 @default.
• W4385691130 cites W2321187741 @default.
• W4385691130 cites W2402058785 @default.
• W4385691130 cites W2465585832 @default.
• W4385691130 cites W2736555108 @default.
• W4385691130 cites W2754561217 @default.
• W4385691130 cites W2767814354 @default.
• W4385691130 cites W2791311131 @default.
• W4385691130 cites W2800988230 @default.
• W4385691130 cites W2803351385 @default.
• W4385691130 cites W2809388401 @default.
• W4385691130 cites W2817094287 @default.
• W4385691130 cites W2878163208 @default.
• W4385691130 cites W2883793199 @default.
• W4385691130 cites W2904866597 @default.
• W4385691130 cites W2910628185 @default.
• W4385691130 cites W2912085080 @default.
• W4385691130 cites W2943248099 @default.
• W4385691130 cites W2947586542 @default.
• W4385691130 cites W2949073548 @default.
• W4385691130 cites W2951234218 @default.
• W4385691130 cites W2969718030 @default.
• W4385691130 cites W3005835152 @default.
• W4385691130 cites W3005968613 @default.
• W4385691130 cites W3016372696 @default.
• W4385691130 cites W3020453117 @default.
• W4385691130 cites W3024238318 @default.
• W4385691130 cites W3025963246 @default.
• W4385691130 cites W3033438356 @default.
• W4385691130 cites W3033860566 @default.
• W4385691130 cites W3037116187 @default.
• W4385691130 cites W3041720930 @default.
• W4385691130 cites W3045694603 @default.
• W4385691130 cites W3083842030 @default.
• W4385691130 cites W3087399576 @default.
• W4385691130 cites W3091873218 @default.
• W4385691130 cites W3093729703 @default.
• W4385691130 cites W3111333306 @default.
• W4385691130 cites W3119952098 @default.
• W4385691130 cites W3128921352 @default.
• W4385691130 cites W3165385073 @default.
• W4385691130 cites W3176675725 @default.
• W4385691130 cites W3190446843 @default.
• W4385691130 cites W3192348655 @default.
• W4385691130 cites W4200442005 @default.
• W4385691130 cites W4206335381 @default.
• W4385691130 cites W4210486171 @default.
• W4385691130 cites W4214853941 @default.
• W4385691130 cites W4229039498 @default.
• W4385691130 cites W4282979227 @default.
• W4385691130 cites W4286256669 @default.
• W4385691130 cites W4296020198 @default.
• W4385691130 cites W4296351635 @default.
• W4385691130 cites W4312204543 @default.
• W4385691130 cites W4327956074 @default.
• W4385691130 doi "https://doi.org/10.1016/j.jep.2023.117021" @default.
• W4385691130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37567424" @default.
• W4385691130 hasPublicationYear "2024" @default.
• W4385691130 type Work @default.
• W4385691130 citedByCount "0" @default.
• W4385691130 crossrefType "journal-article" @default.
• W4385691130 hasAuthorship W4385691130A5021006904 @default.

• next