Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385691696> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4385691696 endingPage "76.01" @default.
- W4385691696 startingPage "76.01" @default.
- W4385691696 abstract "Abstract Immunity to infections is crucial to healthy life. However, recent Covid-19 pandemic has shown that comorbidity such as kidney disease and associated uremia impairs immunity against infections. Uremic patients show high susceptible to infections and also exhibit poor antibody responses to vaccine. The mechanisms by which uremia negatively impacts antibody response is unknown. Using multiple mouse models of uremia, we assessed B cells response to model antigen NP-KLH in alum. We show that uremia inhibits both canonical germinal center (GC) and non-canonical extra-follicular B cells response following NP-KLH immunization. Immunized uremic mice demonstrated compromised affinity maturation, isotype switching, antigen-specific antibody secreting cells, antibody titer and T follicular helper cells response. Consequently, uremic mice exhibited diminished GC and antibody response following prime-boost immunization. B cells showed increased cell cycle arrest, apoptosis and impaired migration between light and dark zone in the uremic GCs. We identified uremic toxin hippuric acid as a major driver of loss of mitochondrial membrane potential leading to increased apoptosis in mouse and human B cells. Finally, we show that GC B cells, T follicular helper cells and antibody response were similarly diminished in uremic mice during influenza virus infection, a major cause of mortality in patients with kidney disease. These results shed light on how uremic toxin(s) suppress antimicrobial immunity and vaccine response in individuals with kidney disease. Knowledge gained from this study may pave the path for developing effective therapeutic and preventive strategies in uremic patients against infections including SARS-CoV-2. R01AI142354, R01AI162616 and R21AI159058" @default.
- W4385691696 created "2023-08-10" @default.
- W4385691696 creator A5025037569 @default.
- W4385691696 creator A5025558024 @default.
- W4385691696 creator A5035257973 @default.
- W4385691696 creator A5041067402 @default.
- W4385691696 creator A5061828608 @default.
- W4385691696 creator A5078696203 @default.
- W4385691696 creator A5085072225 @default.
- W4385691696 date "2023-05-01" @default.
- W4385691696 modified "2023-09-27" @default.
- W4385691696 title "Kidney disease impairs B cells response against infection via inhibiting germinal center formation and antibody titers" @default.
- W4385691696 doi "https://doi.org/10.4049/jimmunol.210.supp.76.01" @default.
- W4385691696 hasPublicationYear "2023" @default.
- W4385691696 type Work @default.
- W4385691696 citedByCount "0" @default.
- W4385691696 crossrefType "journal-article" @default.
- W4385691696 hasAuthorship W4385691696A5025037569 @default.
- W4385691696 hasAuthorship W4385691696A5025558024 @default.
- W4385691696 hasAuthorship W4385691696A5035257973 @default.
- W4385691696 hasAuthorship W4385691696A5041067402 @default.
- W4385691696 hasAuthorship W4385691696A5061828608 @default.
- W4385691696 hasAuthorship W4385691696A5078696203 @default.
- W4385691696 hasAuthorship W4385691696A5085072225 @default.
- W4385691696 hasBestOaLocation W43856916961 @default.
- W4385691696 hasConcept C134018914 @default.
- W4385691696 hasConcept C137756551 @default.
- W4385691696 hasConcept C147483822 @default.
- W4385691696 hasConcept C159047783 @default.
- W4385691696 hasConcept C159654299 @default.
- W4385691696 hasConcept C203014093 @default.
- W4385691696 hasConcept C22889606 @default.
- W4385691696 hasConcept C2776635150 @default.
- W4385691696 hasConcept C2778453870 @default.
- W4385691696 hasConcept C32611913 @default.
- W4385691696 hasConcept C86803240 @default.
- W4385691696 hasConcept C96926380 @default.
- W4385691696 hasConceptScore W4385691696C134018914 @default.
- W4385691696 hasConceptScore W4385691696C137756551 @default.
- W4385691696 hasConceptScore W4385691696C147483822 @default.
- W4385691696 hasConceptScore W4385691696C159047783 @default.
- W4385691696 hasConceptScore W4385691696C159654299 @default.
- W4385691696 hasConceptScore W4385691696C203014093 @default.
- W4385691696 hasConceptScore W4385691696C22889606 @default.
- W4385691696 hasConceptScore W4385691696C2776635150 @default.
- W4385691696 hasConceptScore W4385691696C2778453870 @default.
- W4385691696 hasConceptScore W4385691696C32611913 @default.
- W4385691696 hasConceptScore W4385691696C86803240 @default.
- W4385691696 hasConceptScore W4385691696C96926380 @default.
- W4385691696 hasIssue "1_Supplement" @default.
- W4385691696 hasLocation W43856916961 @default.
- W4385691696 hasOpenAccess W4385691696 @default.
- W4385691696 hasPrimaryLocation W43856916961 @default.
- W4385691696 hasRelatedWork W1803508310 @default.
- W4385691696 hasRelatedWork W2040191638 @default.
- W4385691696 hasRelatedWork W2048365604 @default.
- W4385691696 hasRelatedWork W2132355728 @default.
- W4385691696 hasRelatedWork W2136877952 @default.
- W4385691696 hasRelatedWork W230410763 @default.
- W4385691696 hasRelatedWork W2940853430 @default.
- W4385691696 hasRelatedWork W2965090569 @default.
- W4385691696 hasRelatedWork W4200418268 @default.
- W4385691696 hasRelatedWork W4206021265 @default.
- W4385691696 hasVolume "210" @default.
- W4385691696 isParatext "false" @default.
- W4385691696 isRetracted "false" @default.
- W4385691696 workType "article" @default.