Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385691878> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W4385691878 endingPage "88.05" @default.
- W4385691878 startingPage "88.05" @default.
- W4385691878 abstract "Abstract The Westernized diet refers to consuming high amounts of saturated fat, sugar, and salt, and low amounts of dietary fiber. Such a diet is currently thought to contribute to non-communicable diseases such as autoimmune diseases, heart disease, and cancer. A high-salt diet (HSD) is known to affect various organs, including the cardiovascular, renal, and central nervous systems. Recently, several studies reported the effect of HSD on cancer due to the enhanced osmolarity of tumor microenvironment. However, it has been known that the concentration of sodium in brain is tightly regulated. That is, there may be another effect of HSD to tumor environment in brain. In addition, the effects of HSD on brain tumor have not been elucidated. In this study, we observed an increased tumor burden in mice who received the high-salt diet. Mice on a high-salt diet also showed a change in their gut microbiota. The specific bacteria significantly increased in HSD group compared to normal-salt diet (NSD) group. This bacteria is known to produce several metabolites, and we measured these metabolites in cecum of NSD and HSD group. Among them, the one metabolite increased in HSD group and we supplemented this metabolite to mice with brain tumor. Then, we observed the exacerbation of brain tumor post the supplement compared to control group. Therefore, we speculated that the HSD exacerbated brain tumor via the increased production of metabolite by altered gut microbiota." @default.
- W4385691878 created "2023-08-10" @default.
- W4385691878 creator A5008590783 @default.
- W4385691878 creator A5026339029 @default.
- W4385691878 creator A5031437702 @default.
- W4385691878 creator A5091444186 @default.
- W4385691878 creator A5091543126 @default.
- W4385691878 date "2023-05-01" @default.
- W4385691878 modified "2023-09-27" @default.
- W4385691878 title "The metabolite derived from high-salt diet-induced gut microbiota modulates brain tumor environment" @default.
- W4385691878 doi "https://doi.org/10.4049/jimmunol.210.supp.88.05" @default.
- W4385691878 hasPublicationYear "2023" @default.
- W4385691878 type Work @default.
- W4385691878 citedByCount "0" @default.
- W4385691878 crossrefType "journal-article" @default.
- W4385691878 hasAuthorship W4385691878A5008590783 @default.
- W4385691878 hasAuthorship W4385691878A5026339029 @default.
- W4385691878 hasAuthorship W4385691878A5031437702 @default.
- W4385691878 hasAuthorship W4385691878A5091444186 @default.
- W4385691878 hasAuthorship W4385691878A5091543126 @default.
- W4385691878 hasBestOaLocation W43856918781 @default.
- W4385691878 hasConcept C121608353 @default.
- W4385691878 hasConcept C126322002 @default.
- W4385691878 hasConcept C134018914 @default.
- W4385691878 hasConcept C2777477808 @default.
- W4385691878 hasConcept C539455810 @default.
- W4385691878 hasConcept C55493867 @default.
- W4385691878 hasConcept C71924100 @default.
- W4385691878 hasConcept C86803240 @default.
- W4385691878 hasConceptScore W4385691878C121608353 @default.
- W4385691878 hasConceptScore W4385691878C126322002 @default.
- W4385691878 hasConceptScore W4385691878C134018914 @default.
- W4385691878 hasConceptScore W4385691878C2777477808 @default.
- W4385691878 hasConceptScore W4385691878C539455810 @default.
- W4385691878 hasConceptScore W4385691878C55493867 @default.
- W4385691878 hasConceptScore W4385691878C71924100 @default.
- W4385691878 hasConceptScore W4385691878C86803240 @default.
- W4385691878 hasIssue "1_Supplement" @default.
- W4385691878 hasLocation W43856918781 @default.
- W4385691878 hasOpenAccess W4385691878 @default.
- W4385691878 hasPrimaryLocation W43856918781 @default.
- W4385691878 hasRelatedWork W1966504330 @default.
- W4385691878 hasRelatedWork W1966775726 @default.
- W4385691878 hasRelatedWork W1979139803 @default.
- W4385691878 hasRelatedWork W1991560548 @default.
- W4385691878 hasRelatedWork W2030889776 @default.
- W4385691878 hasRelatedWork W2037631372 @default.
- W4385691878 hasRelatedWork W2040058909 @default.
- W4385691878 hasRelatedWork W2063957970 @default.
- W4385691878 hasRelatedWork W2132898409 @default.
- W4385691878 hasRelatedWork W4249176446 @default.
- W4385691878 hasVolume "210" @default.
- W4385691878 isParatext "false" @default.
- W4385691878 isRetracted "false" @default.
- W4385691878 workType "article" @default.