Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385692015> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4385692015 endingPage "86.12" @default.
- W4385692015 startingPage "86.12" @default.
- W4385692015 abstract "Abstract Tumors evade immune surveillance by creating a hostile environment that impairs the functions of immune cells. Persistent perturbations including chronic antigen stimulation and metabolic challenges cause endoplasmic reticulum (ER) stress and unfolded protein responses (UPR) in T cells. CNPY2 is one of the key initiators of UPR in the ER, but its roles in T cell activation and persistence have not been reported. Herein, we found that the expressions of CNPY2 and other molecules in UPR pathways were upregulated in both activated and exhausted T cells, indicating UPR activation. However, genetic deletion of Cnpy2 in CD8 +T cells did not result in changes in viability, proliferation, mitochondrial functions, and protein translation rate under acute or chronic antigen stimulation in vitro. Furthermore, no differences were seen between wild-type and CD8-specific Cnpy2 knockout mice in protection against multiple syngeneic tumor models including colon (MC38 and CT26), bladder (MB49), melanoma (YUMM1.7 and B16-F10) and breast tumors (4T1). Although CD8 +T cells from tumors were moderately more activated in the absence of CNPY2, no apparent impact was observed on CD8 +infiltration and effector differentiation. Finally, by mRNA profiling and proteomic analysis, we found that the downstream UPR signaling pathways remained intact in T cells despite loss of CNPY2. In summary, we concluded that persistent TCR stimulation and the tumor microenvironment induce CNPY2 expression and UPR in CD8 +T cells. However, ablating CNPY2 alone failed to overcome UPR-mediated T cell dysfunction, suggesting that targeting multiple initiators of UPRs in CD8 +T cells need to be considered to improve cancer immunotherapy." @default.
- W4385692015 created "2023-08-10" @default.
- W4385692015 creator A5002360335 @default.
- W4385692015 creator A5017747503 @default.
- W4385692015 creator A5031953660 @default.
- W4385692015 creator A5032151945 @default.
- W4385692015 creator A5053010839 @default.
- W4385692015 creator A5062652489 @default.
- W4385692015 creator A5085338227 @default.
- W4385692015 date "2023-05-01" @default.
- W4385692015 modified "2023-10-02" @default.
- W4385692015 title "CNPY2-orchestrated unfolded protein responses play redundant roles in regulating anti-tumor immunity of CD8 +T cells" @default.
- W4385692015 doi "https://doi.org/10.4049/jimmunol.210.supp.86.12" @default.
- W4385692015 hasPublicationYear "2023" @default.
- W4385692015 type Work @default.
- W4385692015 citedByCount "0" @default.
- W4385692015 crossrefType "journal-article" @default.
- W4385692015 hasAuthorship W4385692015A5002360335 @default.
- W4385692015 hasAuthorship W4385692015A5017747503 @default.
- W4385692015 hasAuthorship W4385692015A5031953660 @default.
- W4385692015 hasAuthorship W4385692015A5032151945 @default.
- W4385692015 hasAuthorship W4385692015A5053010839 @default.
- W4385692015 hasAuthorship W4385692015A5062652489 @default.
- W4385692015 hasAuthorship W4385692015A5085338227 @default.
- W4385692015 hasBestOaLocation W43856920151 @default.
- W4385692015 hasConcept C139447449 @default.
- W4385692015 hasConcept C147483822 @default.
- W4385692015 hasConcept C154317977 @default.
- W4385692015 hasConcept C158617107 @default.
- W4385692015 hasConcept C167672396 @default.
- W4385692015 hasConcept C19317047 @default.
- W4385692015 hasConcept C202751555 @default.
- W4385692015 hasConcept C203014093 @default.
- W4385692015 hasConcept C2776090121 @default.
- W4385692015 hasConcept C2776107976 @default.
- W4385692015 hasConcept C502942594 @default.
- W4385692015 hasConcept C55493867 @default.
- W4385692015 hasConcept C86803240 @default.
- W4385692015 hasConcept C8891405 @default.
- W4385692015 hasConcept C95444343 @default.
- W4385692015 hasConceptScore W4385692015C139447449 @default.
- W4385692015 hasConceptScore W4385692015C147483822 @default.
- W4385692015 hasConceptScore W4385692015C154317977 @default.
- W4385692015 hasConceptScore W4385692015C158617107 @default.
- W4385692015 hasConceptScore W4385692015C167672396 @default.
- W4385692015 hasConceptScore W4385692015C19317047 @default.
- W4385692015 hasConceptScore W4385692015C202751555 @default.
- W4385692015 hasConceptScore W4385692015C203014093 @default.
- W4385692015 hasConceptScore W4385692015C2776090121 @default.
- W4385692015 hasConceptScore W4385692015C2776107976 @default.
- W4385692015 hasConceptScore W4385692015C502942594 @default.
- W4385692015 hasConceptScore W4385692015C55493867 @default.
- W4385692015 hasConceptScore W4385692015C86803240 @default.
- W4385692015 hasConceptScore W4385692015C8891405 @default.
- W4385692015 hasConceptScore W4385692015C95444343 @default.
- W4385692015 hasIssue "1_Supplement" @default.
- W4385692015 hasLocation W43856920151 @default.
- W4385692015 hasOpenAccess W4385692015 @default.
- W4385692015 hasPrimaryLocation W43856920151 @default.
- W4385692015 hasRelatedWork W1998895168 @default.
- W4385692015 hasRelatedWork W2003338675 @default.
- W4385692015 hasRelatedWork W2072667779 @default.
- W4385692015 hasRelatedWork W2081690197 @default.
- W4385692015 hasRelatedWork W2086116768 @default.
- W4385692015 hasRelatedWork W2894384976 @default.
- W4385692015 hasRelatedWork W3034337622 @default.
- W4385692015 hasRelatedWork W3142122528 @default.
- W4385692015 hasRelatedWork W4220756668 @default.
- W4385692015 hasRelatedWork W4311514635 @default.
- W4385692015 hasVolume "210" @default.
- W4385692015 isParatext "false" @default.
- W4385692015 isRetracted "false" @default.
- W4385692015 workType "article" @default.