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- W4385693265 startingPage "e0289066" @default.
- W4385693265 abstract "The phenomenon in which the expected Mendelian inheritance is altered is known as transmission ratio distortion (TRD). The TRD analysis relies on the study of the transmission of one of the two alleles from a heterozygous parent to the offspring. These distortions are due to biological mechanisms affecting gametogenesis, embryo development and/or postnatal viability, among others. In this study, TRD phenomenon was characterized in horses using SNP-by-SNP model by TRDscan v.2.0 software. A total of 1,041 Pura Raza Español breed horses were genotyped with 554,634 SNPs. Among them, 277 horses genotyped in trios (stallion-mare-offspring) were used to perform the TRD analysis. Our results revealed 140 and 42 SNPs with allelic and genotypic patterns, respectively. Among them, 63 displayed stallion-TRD and 41 exhibited mare-TRD, while 36 SNPs showed overall TRD. In addition, 42 SNPs exhibited heterosis pattern. Functional analyses revealed that the annotated genes located within the TRD regions identified were associated with biological processes and molecular functions related to spermatogenesis, oocyte division, embryonic development, and hormonal activity. A total of 10 functional candidate genes related to fertility were found. To our knowledge, this is the most extensive study performed to evaluate the presence of alleles and functional candidate genes with transmission ratio distortion affecting reproductive performance in the domestic horse." @default.
- W4385693265 created "2023-08-10" @default.
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- W4385693265 date "2023-08-09" @default.
- W4385693265 modified "2023-10-02" @default.
- W4385693265 title "Genomic screening of allelic and genotypic transmission ratio distortion in horse" @default.
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- W4385693265 doi "https://doi.org/10.1371/journal.pone.0289066" @default.
- W4385693265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37556504" @default.
- W4385693265 hasPublicationYear "2023" @default.
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