Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385694018> ?p ?o ?g. }
- W4385694018 abstract "The liver is one of the few organs that retain the capability to regenerate in adult mammals. This regeneration process is mainly facilitated by the dynamic behavior of hepatocytes, which are the major functional constituents in the liver. In response to liver injury, hepatocytes undergo remarkable alterations, such as reprogramming, wherein they lose their original identity and acquire properties from other cells. This phenomenon of hepatocyte reprogramming, coupled with hepatocyte expansion, plays a central role in liver regeneration, and its underlying mechanisms are complex and multifaceted. Understanding the fate of reprogrammed hepatocytes and the mechanisms of their conversion has significant implications for the development of innovative therapeutics for liver diseases. Herein, we review the plasticity of hepatocytes in response to various forms of liver injury, with a focus on injury-induced hepatocyte reprogramming. We provide a comprehensive summary of current knowledge on the molecular and cellular mechanisms governing hepatocyte reprogramming, specifically in the context of liver regeneration, providing insight into potential applications of this process in the treatment of liver disorders, including chronic liver diseases and liver cancer." @default.
- W4385694018 created "2023-08-10" @default.
- W4385694018 creator A5039496752 @default.
- W4385694018 creator A5050690657 @default.
- W4385694018 creator A5059296721 @default.
- W4385694018 creator A5080915717 @default.
- W4385694018 date "2023-08-23" @default.
- W4385694018 modified "2023-10-17" @default.
- W4385694018 title "Hepatocyte reprogramming in liver regeneration: Biological mechanisms and applications" @default.
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