Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385694118> ?p ?o ?g. }
- W4385694118 endingPage "3277" @default.
- W4385694118 startingPage "3266" @default.
- W4385694118 abstract "Nitric oxide (NO) is a ubiquitous messenger molecule playing a key role in various physiological and pathological processes. However, producing a selective turn-on fluorescence response to NO is a challenging task due to (a) the very short half-life of NO (typically in the range of 0.1–10 s) in the biological milieu and (b) false positive responses to reactive carbonyl species (RCS) (e.g., dehydroascorbic acid and methylglyoxal etc.) and some other reactive oxygen/nitrogen species (ROS/RNS), especially with o-phenylenediamine (OPD) based fluorosensors. To avoid these limitations, NO sensors should be designed in such a way that they react spontaneously with NO to give turn-on response within the time frame of t1/2 (typically in the range of 0.1–10 s) of NO and λem in the visible wavelength along with good cell permeability to achieve biocompatibility. With these views in mind, a N-nitrosation based fluorescent sensor, NDAQ, has been developed that is highly selective to NO with ∼27-fold fluorescence enhancement at λem = 542 nm with high sensitivity (LOD = 7 ± 0.4 nM) and shorter response time, eliminating the interference of other reactive species (RCS/ROS/RNS). Furthermore, all the photophysical studies with NDAQ have been performed in 98% aqueous medium at physiological pH, indicating its good stability under physiological conditions. The kinetic assay illustrates the second-order dependency with respect to NO concentration and first-order dependency with respect to NDAQ concentration. The biological studies reveal the successful application of the probe to track both endogenous and exogenous NO in living organisms." @default.
- W4385694118 created "2023-08-10" @default.
- W4385694118 creator A5020540553 @default.
- W4385694118 creator A5026267613 @default.
- W4385694118 creator A5034212708 @default.
- W4385694118 creator A5036452925 @default.
- W4385694118 creator A5047895036 @default.
- W4385694118 creator A5053842109 @default.
- W4385694118 creator A5062699174 @default.
- W4385694118 creator A5091693355 @default.
- W4385694118 date "2023-08-09" @default.
- W4385694118 modified "2023-10-14" @default.
- W4385694118 title "N-Nitrosation Based Fluorescence Turn-On Nitric Oxide Probe: Kinetic and Cell Imaging Studies" @default.
- W4385694118 cites W1589229976 @default.
- W4385694118 cites W1967598732 @default.
- W4385694118 cites W1972508039 @default.
- W4385694118 cites W1979567315 @default.
- W4385694118 cites W1980458823 @default.
- W4385694118 cites W1980486272 @default.
- W4385694118 cites W1985289402 @default.
- W4385694118 cites W1995418515 @default.
- W4385694118 cites W2023271753 @default.
- W4385694118 cites W2029534667 @default.
- W4385694118 cites W2034185909 @default.
- W4385694118 cites W2039559098 @default.
- W4385694118 cites W2041679557 @default.
- W4385694118 cites W2043239658 @default.
- W4385694118 cites W2047128154 @default.
- W4385694118 cites W2049640173 @default.
- W4385694118 cites W2058848030 @default.
- W4385694118 cites W2063400200 @default.
- W4385694118 cites W2068686024 @default.
- W4385694118 cites W2071371679 @default.
- W4385694118 cites W2073648072 @default.
- W4385694118 cites W2076940601 @default.
- W4385694118 cites W2080866897 @default.
- W4385694118 cites W2085640353 @default.
- W4385694118 cites W2088271348 @default.
- W4385694118 cites W2090458427 @default.
- W4385694118 cites W2092145002 @default.
- W4385694118 cites W2106824077 @default.
- W4385694118 cites W2108379152 @default.
- W4385694118 cites W2120428281 @default.
- W4385694118 cites W2122386753 @default.
- W4385694118 cites W2123969193 @default.
- W4385694118 cites W2128912599 @default.
- W4385694118 cites W2143981217 @default.
- W4385694118 cites W2160171664 @default.
- W4385694118 cites W2181241483 @default.
- W4385694118 cites W2315800446 @default.
- W4385694118 cites W2599204659 @default.
- W4385694118 cites W2752499413 @default.
- W4385694118 cites W2784082116 @default.
- W4385694118 cites W2803161980 @default.
- W4385694118 cites W2808401764 @default.
- W4385694118 cites W2894896695 @default.
- W4385694118 cites W2896364202 @default.
- W4385694118 cites W2897598449 @default.
- W4385694118 cites W2912414247 @default.
- W4385694118 cites W2918528115 @default.
- W4385694118 cites W2946279273 @default.
- W4385694118 cites W2995779875 @default.
- W4385694118 cites W3008903336 @default.
- W4385694118 cites W3097377238 @default.
- W4385694118 cites W3193583109 @default.
- W4385694118 cites W907475652 @default.
- W4385694118 doi "https://doi.org/10.1021/acsabm.3c00362" @default.
- W4385694118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37556766" @default.
- W4385694118 hasPublicationYear "2023" @default.
- W4385694118 type Work @default.
- W4385694118 citedByCount "0" @default.
- W4385694118 crossrefType "journal-article" @default.
- W4385694118 hasAuthorship W4385694118A5020540553 @default.
- W4385694118 hasAuthorship W4385694118A5026267613 @default.
- W4385694118 hasAuthorship W4385694118A5034212708 @default.
- W4385694118 hasAuthorship W4385694118A5036452925 @default.
- W4385694118 hasAuthorship W4385694118A5047895036 @default.
- W4385694118 hasAuthorship W4385694118A5053842109 @default.
- W4385694118 hasAuthorship W4385694118A5062699174 @default.
- W4385694118 hasAuthorship W4385694118A5091693355 @default.
- W4385694118 hasConcept C104882015 @default.
- W4385694118 hasConcept C121332964 @default.
- W4385694118 hasConcept C12554922 @default.
- W4385694118 hasConcept C178790620 @default.
- W4385694118 hasConcept C181199279 @default.
- W4385694118 hasConcept C185592680 @default.
- W4385694118 hasConcept C2777230088 @default.
- W4385694118 hasConcept C2778592357 @default.
- W4385694118 hasConcept C2779525624 @default.
- W4385694118 hasConcept C48349386 @default.
- W4385694118 hasConcept C49853544 @default.
- W4385694118 hasConcept C519581460 @default.
- W4385694118 hasConcept C55493867 @default.
- W4385694118 hasConcept C62520636 @default.
- W4385694118 hasConcept C75473681 @default.
- W4385694118 hasConcept C86803240 @default.
- W4385694118 hasConcept C91881484 @default.
- W4385694118 hasConceptScore W4385694118C104882015 @default.