Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385695657> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4385695657 endingPage "243.17" @default.
- W4385695657 startingPage "243.17" @default.
- W4385695657 abstract "Abstract IL-6 is an important signal three cytokine for T helper 17 (Th17) and T follicular helper (Tfh) differentiation. Previous work has suggested a possible role for TRAF3 in the function and/or differentiation of these two subsets, but no direct studies have yet been performed. In this study, we examine the role of TRAF3 in IL-6R signaling in T cells. TRAF3 regulates IL-2R and type I interferon receptor signaling in T cells by altering recruitment of the phosphatases PTPN2 and PTPN22, respectively. B cell TRAF3 curtails IL-6R signaling by recruiting PTPN22, thus we hypothesized that TRAF3 regulates T cell IL-6R signaling through a PTPN22-dependent mechanism. We investigated the role of T cell TRAF3 using a TRAF3-deficient human T cell lymphoma line and a T cells from a T cell-specific TRAF3 knockout mouse (T-Traf3−/−). We found reduced IL-6-induced STAT1 and STAT3 activation in human and mouse T cells. STAT1 and STAT3 activation are both required for full differentiation of mouse Tfh cells, whereas STAT3 is required for and STAT1 antagonizes Th17 differentiation. Interestingly, in vitrodifferentiation of naïve CD4 T cells to Th17 cells was not affected by TRAF3 deficiency. To determine the mechanism by which TRAF3 promotes STAT1 and STAT3 activation in response to IL-6R signaling, we treated WT and Traf3−/−T cells with IL-6 in the presence of PTPN22 inhibitor or vehicle control. We found that PTPN22 inhibition restored activation of STAT3, but did not restore activation of STAT1, suggesting different mechanisms of regulation. Together these data implicate TRAF3 in regulation of IL-6R signaling in a partly PTPN22-dependent manner, lending an additional level of understanding to TRAF3 regulation of Th17 and Tfh differentiation. Supported by NIH R01 AI123107, R01 AI162656, T32 AI007260" @default.
- W4385695657 created "2023-08-10" @default.
- W4385695657 creator A5015571143 @default.
- W4385695657 creator A5019550435 @default.
- W4385695657 creator A5037876294 @default.
- W4385695657 creator A5057604637 @default.
- W4385695657 date "2023-05-01" @default.
- W4385695657 modified "2023-09-27" @default.
- W4385695657 title "TRAF3 regulates IL-6 receptor signaling in T cells through the phosphatase PTPN22" @default.
- W4385695657 doi "https://doi.org/10.4049/jimmunol.210.supp.243.17" @default.
- W4385695657 hasPublicationYear "2023" @default.
- W4385695657 type Work @default.
- W4385695657 citedByCount "0" @default.
- W4385695657 crossrefType "journal-article" @default.
- W4385695657 hasAuthorship W4385695657A5015571143 @default.
- W4385695657 hasAuthorship W4385695657A5019550435 @default.
- W4385695657 hasAuthorship W4385695657A5037876294 @default.
- W4385695657 hasAuthorship W4385695657A5057604637 @default.
- W4385695657 hasBestOaLocation W43856956571 @default.
- W4385695657 hasConcept C120642132 @default.
- W4385695657 hasConcept C129374314 @default.
- W4385695657 hasConcept C159654299 @default.
- W4385695657 hasConcept C203014093 @default.
- W4385695657 hasConcept C2776090121 @default.
- W4385695657 hasConcept C2778453870 @default.
- W4385695657 hasConcept C62478195 @default.
- W4385695657 hasConcept C86803240 @default.
- W4385695657 hasConcept C8891405 @default.
- W4385695657 hasConcept C95444343 @default.
- W4385695657 hasConcept C96926380 @default.
- W4385695657 hasConceptScore W4385695657C120642132 @default.
- W4385695657 hasConceptScore W4385695657C129374314 @default.
- W4385695657 hasConceptScore W4385695657C159654299 @default.
- W4385695657 hasConceptScore W4385695657C203014093 @default.
- W4385695657 hasConceptScore W4385695657C2776090121 @default.
- W4385695657 hasConceptScore W4385695657C2778453870 @default.
- W4385695657 hasConceptScore W4385695657C62478195 @default.
- W4385695657 hasConceptScore W4385695657C86803240 @default.
- W4385695657 hasConceptScore W4385695657C8891405 @default.
- W4385695657 hasConceptScore W4385695657C95444343 @default.
- W4385695657 hasConceptScore W4385695657C96926380 @default.
- W4385695657 hasIssue "1_Supplement" @default.
- W4385695657 hasLocation W43856956571 @default.
- W4385695657 hasOpenAccess W4385695657 @default.
- W4385695657 hasPrimaryLocation W43856956571 @default.
- W4385695657 hasRelatedWork W1609716101 @default.
- W4385695657 hasRelatedWork W1853217298 @default.
- W4385695657 hasRelatedWork W2049406042 @default.
- W4385695657 hasRelatedWork W2068937296 @default.
- W4385695657 hasRelatedWork W2104430732 @default.
- W4385695657 hasRelatedWork W2140748367 @default.
- W4385695657 hasRelatedWork W2157130851 @default.
- W4385695657 hasRelatedWork W2589837959 @default.
- W4385695657 hasRelatedWork W2626401665 @default.
- W4385695657 hasRelatedWork W4306155276 @default.
- W4385695657 hasVolume "210" @default.
- W4385695657 isParatext "false" @default.
- W4385695657 isRetracted "false" @default.
- W4385695657 workType "article" @default.