Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385697472> ?p ?o ?g. }
- W4385697472 endingPage "3725.e29" @default.
- W4385697472 startingPage "3706" @default.
- W4385697472 abstract "The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related pathways and a unique synaptic protein signature. 3D imaging demonstrates the structural and cellular details of human skull-meninges connections (SMCs) compared with veins. Last, using translocator protein positron emission tomography (TSPO-PET) imaging, we show that the skull bone marrow reflects inflammatory brain responses with a disease-specific spatial distribution in patients with various neurological disorders. The unique molecular profile and anatomical and functional connections of the skull show its potential as a site for diagnosing, monitoring, and treating brain diseases." @default.
- W4385697472 created "2023-08-10" @default.
- W4385697472 creator A5005297652 @default.
- W4385697472 creator A5007745122 @default.
- W4385697472 creator A5008676221 @default.
- W4385697472 creator A5009150377 @default.
- W4385697472 creator A5009336244 @default.
- W4385697472 creator A5009912914 @default.
- W4385697472 creator A5012774257 @default.
- W4385697472 creator A5013040609 @default.
- W4385697472 creator A5013373738 @default.
- W4385697472 creator A5013441539 @default.
- W4385697472 creator A5013715586 @default.
- W4385697472 creator A5016384141 @default.
- W4385697472 creator A5018163868 @default.
- W4385697472 creator A5019649619 @default.
- W4385697472 creator A5020486321 @default.
- W4385697472 creator A5021067270 @default.
- W4385697472 creator A5022202675 @default.
- W4385697472 creator A5022920379 @default.
- W4385697472 creator A5025850978 @default.
- W4385697472 creator A5026632860 @default.
- W4385697472 creator A5029811117 @default.
- W4385697472 creator A5030943885 @default.
- W4385697472 creator A5031299992 @default.
- W4385697472 creator A5032644974 @default.
- W4385697472 creator A5033304047 @default.
- W4385697472 creator A5037488110 @default.
- W4385697472 creator A5037837078 @default.
- W4385697472 creator A5039302048 @default.
- W4385697472 creator A5041604591 @default.
- W4385697472 creator A5041891850 @default.
- W4385697472 creator A5042949590 @default.
- W4385697472 creator A5043143732 @default.
- W4385697472 creator A5044424817 @default.
- W4385697472 creator A5044548860 @default.
- W4385697472 creator A5044672021 @default.
- W4385697472 creator A5044783585 @default.
- W4385697472 creator A5044946054 @default.
- W4385697472 creator A5045309202 @default.
- W4385697472 creator A5047813770 @default.
- W4385697472 creator A5048249357 @default.
- W4385697472 creator A5049155219 @default.
- W4385697472 creator A5049527280 @default.
- W4385697472 creator A5049725109 @default.
- W4385697472 creator A5050089950 @default.
- W4385697472 creator A5050828185 @default.
- W4385697472 creator A5051575017 @default.
- W4385697472 creator A5052726503 @default.
- W4385697472 creator A5052848358 @default.
- W4385697472 creator A5056671780 @default.
- W4385697472 creator A5057080547 @default.
- W4385697472 creator A5057836701 @default.
- W4385697472 creator A5058605780 @default.
- W4385697472 creator A5059736655 @default.
- W4385697472 creator A5061123357 @default.
- W4385697472 creator A5061756697 @default.
- W4385697472 creator A5062488095 @default.
- W4385697472 creator A5062596871 @default.
- W4385697472 creator A5063796179 @default.
- W4385697472 creator A5065084452 @default.
- W4385697472 creator A5065549960 @default.
- W4385697472 creator A5066374633 @default.
- W4385697472 creator A5066625527 @default.
- W4385697472 creator A5068735853 @default.
- W4385697472 creator A5068749612 @default.
- W4385697472 creator A5071417420 @default.
- W4385697472 creator A5074026817 @default.
- W4385697472 creator A5074840208 @default.
- W4385697472 creator A5074953707 @default.
- W4385697472 creator A5079565983 @default.
- W4385697472 creator A5079895873 @default.
- W4385697472 creator A5080010365 @default.
- W4385697472 creator A5080142972 @default.
- W4385697472 creator A5080395418 @default.
- W4385697472 creator A5081627019 @default.
- W4385697472 creator A5082921381 @default.
- W4385697472 creator A5084033552 @default.
- W4385697472 creator A5085027983 @default.
- W4385697472 creator A5085712205 @default.
- W4385697472 creator A5086692348 @default.
- W4385697472 creator A5087554087 @default.
- W4385697472 creator A5088615061 @default.
- W4385697472 creator A5090279914 @default.
- W4385697472 creator A5092618160 @default.
- W4385697472 creator A5092618161 @default.
- W4385697472 creator A5092618162 @default.
- W4385697472 date "2023-08-01" @default.
- W4385697472 modified "2023-10-12" @default.
- W4385697472 title "Distinct molecular profiles of skull bone marrow in health and neurological disorders" @default.
- W4385697472 cites W1820933137 @default.
- W4385697472 cites W1960895270 @default.
- W4385697472 cites W1968588215 @default.
- W4385697472 cites W1981267809 @default.
- W4385697472 cites W2004229999 @default.
- W4385697472 cites W2005130936 @default.
- W4385697472 cites W2016097940 @default.
- W4385697472 cites W2026863186 @default.