Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385697788> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4385697788 abstract "Background: A hematopoietic stem cell transplant (HSCT) includes a conditioning regimen which may cause unwanted metabolic changes. Objective: Analyze the changes in electrolytes, glucose, urea and glomerular filtration rate in patients with MS who underwent an autologous HSCT employing the “Mexican method”. Methods: Serum and urinary electrolytes, blood glucose, creatinine, uric acid and estimated glomerular filtration rate (eGFR) were prospectively assessed on days -11, - 9, and 0 in a group of 75 patients with multiple sclerosis (MS) receiving an autologous HSCT employing the “Mexican Method”, which includes high doses of both cyclophosphamide (Cy, 200 mg/Kg) and rituximab (1000 mg). Results: The median age of the patients was 46 years, with a range of 20 to 65. Baseline data were defined at day -11 of the HSCT. There were significant changes in serum and urinary electrolytes, which diminished substantially after the delivery of high-dose Cy. 12 patients (16%) developed hyponatremia and two had hyponatremiainduced seizures which resulted in hospital admissions. A comparison of baseline blood metabolites with those obtained after the full Cy dosage (day 0), revealed a significant increase in blood glucose and uric acid with an associated decrease in serum calcium, sodium, and potassium. The salient findings were drug-induced hyponatremia and hyperglycemia. Conclusion: Significant changes in serum electrolytes, blood glucose, creatinine, uric acid and estimated glomerular filtration rate (eGFR) were observed in patients given autologous HSCT for MS, employing high-dose Cy. Some of these changes may have clinical consequences, mainly those derived from iatrogenic hyponatremia. No evidence of damage to renal function was observed at day 0." @default.
- W4385697788 created "2023-08-10" @default.
- W4385697788 creator A5022592090 @default.
- W4385697788 creator A5046075487 @default.
- W4385697788 creator A5073513033 @default.
- W4385697788 creator A5092618223 @default.
- W4385697788 date "2023-01-01" @default.
- W4385697788 modified "2023-10-01" @default.
- W4385697788 title "Serum electrolyte and metabolic changes during conditioning of autologous hematopoietic stem cell transplantation in patients with autoimmune diseases: A prospective study in a single institution." @default.
- W4385697788 doi "https://doi.org/10.56875/2589-0646.1106" @default.
- W4385697788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37581466" @default.
- W4385697788 hasPublicationYear "2023" @default.
- W4385697788 type Work @default.
- W4385697788 citedByCount "0" @default.
- W4385697788 crossrefType "journal-article" @default.
- W4385697788 hasAuthorship W4385697788A5022592090 @default.
- W4385697788 hasAuthorship W4385697788A5046075487 @default.
- W4385697788 hasAuthorship W4385697788A5073513033 @default.
- W4385697788 hasAuthorship W4385697788A5092618223 @default.
- W4385697788 hasBestOaLocation W43856977881 @default.
- W4385697788 hasConcept C126322002 @default.
- W4385697788 hasConcept C126894567 @default.
- W4385697788 hasConcept C134018914 @default.
- W4385697788 hasConcept C159641895 @default.
- W4385697788 hasConcept C2776703092 @default.
- W4385697788 hasConcept C2777408962 @default.
- W4385697788 hasConcept C2779881121 @default.
- W4385697788 hasConcept C2780306776 @default.
- W4385697788 hasConcept C2911091166 @default.
- W4385697788 hasConcept C71924100 @default.
- W4385697788 hasConcept C90924648 @default.
- W4385697788 hasConceptScore W4385697788C126322002 @default.
- W4385697788 hasConceptScore W4385697788C126894567 @default.
- W4385697788 hasConceptScore W4385697788C134018914 @default.
- W4385697788 hasConceptScore W4385697788C159641895 @default.
- W4385697788 hasConceptScore W4385697788C2776703092 @default.
- W4385697788 hasConceptScore W4385697788C2777408962 @default.
- W4385697788 hasConceptScore W4385697788C2779881121 @default.
- W4385697788 hasConceptScore W4385697788C2780306776 @default.
- W4385697788 hasConceptScore W4385697788C2911091166 @default.
- W4385697788 hasConceptScore W4385697788C71924100 @default.
- W4385697788 hasConceptScore W4385697788C90924648 @default.
- W4385697788 hasIssue "1" @default.
- W4385697788 hasLocation W43856977881 @default.
- W4385697788 hasLocation W43856977882 @default.
- W4385697788 hasOpenAccess W4385697788 @default.
- W4385697788 hasPrimaryLocation W43856977881 @default.
- W4385697788 hasRelatedWork W1486584413 @default.
- W4385697788 hasRelatedWork W1544023406 @default.
- W4385697788 hasRelatedWork W1973741567 @default.
- W4385697788 hasRelatedWork W1974378936 @default.
- W4385697788 hasRelatedWork W2000788972 @default.
- W4385697788 hasRelatedWork W2046899919 @default.
- W4385697788 hasRelatedWork W2087086071 @default.
- W4385697788 hasRelatedWork W3117263584 @default.
- W4385697788 hasRelatedWork W393698729 @default.
- W4385697788 hasRelatedWork W4296385806 @default.
- W4385697788 hasVolume "17" @default.
- W4385697788 isParatext "false" @default.
- W4385697788 isRetracted "false" @default.
- W4385697788 workType "article" @default.