FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385703979> ?p ?o ?g. }

• W4385703979 abstract "Previous studies have identified that chromosome structure plays a very important role in gene control. The transcription factor Yin Yang 1 (YY1), a multifunctional DNA binding protein, could form a dimer to mediate chromatin loops and active enhancer-promoter interactions. The deletion of YY1 or point mutations at the YY1 binding sites significantly inhibit the enhancer-promoter interactions and affect gene expression. To date, only a few computational methods are available for identifying YY1-mediated chromatin loops.We proposed a novel model named CapsNetYY1, which was based on capsule network architecture to identify whether a pair of YY1 motifs can form a chromatin loop. Firstly, we encode the DNA sequence using one-hot encoding method. Secondly, multi-scale convolution layer is used to extract local features of the sequence, and bidirectional gated recurrent unit is used to learn the features across time steps. Finally, capsule networks (convolution capsule layer and digital capsule layer) used to extract higher level features and recognize YY1-mediated chromatin loops. Compared with DeepYY1, the only prediction for YY1-mediated chromatin loops, our model CapsNetYY1 achieved the better performance on the independent datasets (AUC [Formula: see text]).The results indicate that CapsNetYY1 is an excellent method for identifying YY1-mediated chromatin loops. We believe that the CapsNetYY1 method will be used for predictive classification of other DNA sequences." @default.
• W4385703979 created "2023-08-10" @default.
• W4385703979 creator A5055546418 @default.
• W4385703979 creator A5064185915 @default.
• W4385703979 creator A5064650299 @default.
• W4385703979 creator A5078955823 @default.
• W4385703979 date "2023-08-09" @default.
• W4385703979 modified "2023-10-16" @default.
• W4385703979 title "CapsNetYY1: identifying YY1-mediated chromatin loops based on a capsule network architecture" @default.
• W4385703979 cites W1807324513 @default.
• W4385703979 cites W1922881706 @default.
• W4385703979 cites W1941076503 @default.
• W4385703979 cites W1964184081 @default.
• W4385703979 cites W1976526581 @default.
• W4385703979 cites W1989373989 @default.
• W4385703979 cites W2018658338 @default.
• W4385703979 cites W2033283522 @default.
• W4385703979 cites W2047005748 @default.
• W4385703979 cites W2068243457 @default.
• W4385703979 cites W2082496903 @default.
• W4385703979 cites W2103525038 @default.
• W4385703979 cites W2140741853 @default.
• W4385703979 cites W2155941870 @default.
• W4385703979 cites W2157825442 @default.
• W4385703979 cites W2161212572 @default.
• W4385703979 cites W2163412235 @default.
• W4385703979 cites W2340540054 @default.
• W4385703979 cites W2341987872 @default.
• W4385703979 cites W2556041461 @default.
• W4385703979 cites W2735099323 @default.
• W4385703979 cites W2774733631 @default.
• W4385703979 cites W2792734199 @default.
• W4385703979 cites W2903682118 @default.
• W4385703979 cites W2952014756 @default.
• W4385703979 cites W2994619710 @default.
• W4385703979 cites W2998913411 @default.
• W4385703979 cites W2999309192 @default.
• W4385703979 cites W3011537067 @default.
• W4385703979 cites W3096581305 @default.
• W4385703979 cites W3109860017 @default.
• W4385703979 cites W3112172360 @default.
• W4385703979 cites W3197003753 @default.
• W4385703979 cites W4200111237 @default.
• W4385703979 cites W4254751698 @default.
• W4385703979 doi "https://doi.org/10.1186/s12864-023-09217-4" @default.
• W4385703979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37559017" @default.
• W4385703979 hasPublicationYear "2023" @default.
• W4385703979 type Work @default.
• W4385703979 citedByCount "0" @default.
• W4385703979 crossrefType "journal-article" @default.
• W4385703979 hasAuthorship W4385703979A5055546418 @default.
• W4385703979 hasAuthorship W4385703979A5064185915 @default.
• W4385703979 hasAuthorship W4385703979A5064650299 @default.
• W4385703979 hasAuthorship W4385703979A5078955823 @default.
• W4385703979 hasBestOaLocation W43857039791 @default.
• W4385703979 hasConcept C101762097 @default.
• W4385703979 hasConcept C104317684 @default.
• W4385703979 hasConcept C111936080 @default.
• W4385703979 hasConcept C134320426 @default.
• W4385703979 hasConcept C150194340 @default.
• W4385703979 hasConcept C167227067 @default.
• W4385703979 hasConcept C176619506 @default.
• W4385703979 hasConcept C54355233 @default.
• W4385703979 hasConcept C552990157 @default.
• W4385703979 hasConcept C62944979 @default.
• W4385703979 hasConcept C67258246 @default.
• W4385703979 hasConcept C70721500 @default.
• W4385703979 hasConcept C83640560 @default.
• W4385703979 hasConcept C86339819 @default.
• W4385703979 hasConcept C86803240 @default.
• W4385703979 hasConceptScore W4385703979C101762097 @default.
• W4385703979 hasConceptScore W4385703979C104317684 @default.
• W4385703979 hasConceptScore W4385703979C111936080 @default.
• W4385703979 hasConceptScore W4385703979C134320426 @default.
• W4385703979 hasConceptScore W4385703979C150194340 @default.
• W4385703979 hasConceptScore W4385703979C167227067 @default.
• W4385703979 hasConceptScore W4385703979C176619506 @default.
• W4385703979 hasConceptScore W4385703979C54355233 @default.
• W4385703979 hasConceptScore W4385703979C552990157 @default.
• W4385703979 hasConceptScore W4385703979C62944979 @default.
• W4385703979 hasConceptScore W4385703979C67258246 @default.
• W4385703979 hasConceptScore W4385703979C70721500 @default.
• W4385703979 hasConceptScore W4385703979C83640560 @default.
• W4385703979 hasConceptScore W4385703979C86339819 @default.
• W4385703979 hasConceptScore W4385703979C86803240 @default.
• W4385703979 hasIssue "1" @default.
• W4385703979 hasLocation W43857039791 @default.
• W4385703979 hasLocation W43857039792 @default.
• W4385703979 hasOpenAccess W4385703979 @default.
• W4385703979 hasPrimaryLocation W43857039791 @default.
• W4385703979 hasRelatedWork W2019005509 @default.
• W4385703979 hasRelatedWork W2076891695 @default.
• W4385703979 hasRelatedWork W2289499401 @default.
• W4385703979 hasRelatedWork W2518011495 @default.
• W4385703979 hasRelatedWork W2532719467 @default.
• W4385703979 hasRelatedWork W2795205332 @default.
• W4385703979 hasRelatedWork W3040477867 @default.
• W4385703979 hasRelatedWork W3097032002 @default.
• W4385703979 hasRelatedWork W3121717247 @default.
• W4385703979 hasRelatedWork W4243928696 @default.

• next