Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385705909> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4385705909 endingPage "e44122af" @default.
- W4385705909 startingPage "e44122af" @default.
- W4385705909 abstract "Topic: 22. Stem cell transplantation - Clinical Background: Secondary failure of platelet recovery (SFPR) is a serious complication after hematopoietic stem cell transplantation (HSCT) and the significance of platelet parameters in SFPR remains unclear. Moreover, the role of CMV infection in SFPR is unclear and the correlation between platelet parameters and CMV infection in patients with SFPR is unknown. Aims: To investigate the clinical significance of changes in platelet parameters in patients with secondary failure of platelet recovery (SFPR) and cytomegalovirus (CMV) infection after hematopoietic stem cell transplantation (HSCT). Methods: In this retrospective study, 79 patients who had undergone allogeneic HSCT (allo-HSCT), including 40 patients with SFPR, between January 2017 and September 2019 at the Stem Cell Transplantation Center of the Hematology Hospital (Institute of Hematology), Chinese Academy of Medical Sciences were included. The evaluated parameters were platelet count (PLT), plateletcrit (PCT), platelet-large cell ratio (P-LCR), mean platelet volume (MPV), platelet distribution width (PDW), incidence of CMV infection after allo-HSCT, and the correlation of SFPR and CMV infection in patients who had undergone allo-HSCT. The control group included 107 healthy donors. Results: The SFPR group had significantly lower megakaryocyte counts, PLT, and PCT and significantly higher P-LCR, MPV, and PDW than the healthy donor and non-SFPR groups. The incidence of CMV infection was higher in SFPR patients than in non-SFPR patients. Among the patients with SFPR, P-LCR, MPV, and PDW were lower in those with CMV DNA >8000 copies/mL than in those with CMV DNA <8000 copies/mL (p < 0.05 for all); the CMV viral load was slightly negatively correlated with MPV (p = 0.0297) and P-LCR (p = 0.0280). Summary/Conclusion: The level of platelet activation in SFPR patients, which was closely related to CMV infection, was higher than that in that in non-SFPR patients, and higher CMV load was associated with the inhibition of platelet activation. Table. CMV infection in non-SFPR group and SFPR group - CMV infection Non-SFPR (n=39 ) SFPR(n=40) P value No CMV infection/case 32 11 CMV infection/case 7 29 CMV <8000(copies/mL)/case 6 24 CMV >8000(copies/mL)/case 1 5 CMV >8000(copies/mL)proportion(%) 14.2 17.2 the incidence of CMV infection（%） 17.9 72.5 P<0.0001 Average copy number(x±s)（copies/mL） 5452±6875.74 7024.21±9109.32 P=0.2022 CMV, Cytomegalovirus. Keywords: Platelet engraftment, Hematopoietic cell transplantation, Platelet activation" @default.
- W4385705909 created "2023-08-10" @default.
- W4385705909 creator A5026508336 @default.
- W4385705909 creator A5029862222 @default.
- W4385705909 creator A5080290845 @default.
- W4385705909 date "2023-08-01" @default.
- W4385705909 modified "2023-09-27" @default.
- W4385705909 title "PB2451: EVALUATION OF PLATELET PARAMETERS IN PATIENTS WITH SECONDARY FAILURE OF PLATELET RECOVERY AND CYTOMEGALOVIRUS INFECTION AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION" @default.
- W4385705909 doi "https://doi.org/10.1097/01.hs9.0000976508.44122.af" @default.
- W4385705909 hasPublicationYear "2023" @default.
- W4385705909 type Work @default.
- W4385705909 citedByCount "0" @default.
- W4385705909 crossrefType "journal-article" @default.
- W4385705909 hasAuthorship W4385705909A5026508336 @default.
- W4385705909 hasAuthorship W4385705909A5029862222 @default.
- W4385705909 hasAuthorship W4385705909A5080290845 @default.
- W4385705909 hasBestOaLocation W43857059091 @default.
- W4385705909 hasConcept C120665830 @default.
- W4385705909 hasConcept C121332964 @default.
- W4385705909 hasConcept C126322002 @default.
- W4385705909 hasConcept C190481736 @default.
- W4385705909 hasConcept C194409129 @default.
- W4385705909 hasConcept C203014093 @default.
- W4385705909 hasConcept C2522874641 @default.
- W4385705909 hasConcept C2776409557 @default.
- W4385705909 hasConcept C2777408962 @default.
- W4385705909 hasConcept C2777732132 @default.
- W4385705909 hasConcept C2780727368 @default.
- W4385705909 hasConcept C28328180 @default.
- W4385705909 hasConcept C2911091166 @default.
- W4385705909 hasConcept C54355233 @default.
- W4385705909 hasConcept C61511704 @default.
- W4385705909 hasConcept C71924100 @default.
- W4385705909 hasConcept C86803240 @default.
- W4385705909 hasConcept C89560881 @default.
- W4385705909 hasConcept C90924648 @default.
- W4385705909 hasConceptScore W4385705909C120665830 @default.
- W4385705909 hasConceptScore W4385705909C121332964 @default.
- W4385705909 hasConceptScore W4385705909C126322002 @default.
- W4385705909 hasConceptScore W4385705909C190481736 @default.
- W4385705909 hasConceptScore W4385705909C194409129 @default.
- W4385705909 hasConceptScore W4385705909C203014093 @default.
- W4385705909 hasConceptScore W4385705909C2522874641 @default.
- W4385705909 hasConceptScore W4385705909C2776409557 @default.
- W4385705909 hasConceptScore W4385705909C2777408962 @default.
- W4385705909 hasConceptScore W4385705909C2777732132 @default.
- W4385705909 hasConceptScore W4385705909C2780727368 @default.
- W4385705909 hasConceptScore W4385705909C28328180 @default.
- W4385705909 hasConceptScore W4385705909C2911091166 @default.
- W4385705909 hasConceptScore W4385705909C54355233 @default.
- W4385705909 hasConceptScore W4385705909C61511704 @default.
- W4385705909 hasConceptScore W4385705909C71924100 @default.
- W4385705909 hasConceptScore W4385705909C86803240 @default.
- W4385705909 hasConceptScore W4385705909C89560881 @default.
- W4385705909 hasConceptScore W4385705909C90924648 @default.
- W4385705909 hasIssue "S3" @default.
- W4385705909 hasLocation W43857059091 @default.
- W4385705909 hasLocation W43857059092 @default.
- W4385705909 hasOpenAccess W4385705909 @default.
- W4385705909 hasPrimaryLocation W43857059091 @default.
- W4385705909 hasRelatedWork W1565849830 @default.
- W4385705909 hasRelatedWork W1939317775 @default.
- W4385705909 hasRelatedWork W1996182916 @default.
- W4385705909 hasRelatedWork W2004368639 @default.
- W4385705909 hasRelatedWork W2027173317 @default.
- W4385705909 hasRelatedWork W2033219189 @default.
- W4385705909 hasRelatedWork W2352827433 @default.
- W4385705909 hasRelatedWork W2987748674 @default.
- W4385705909 hasRelatedWork W3029049270 @default.
- W4385705909 hasRelatedWork W4220935603 @default.
- W4385705909 hasVolume "7" @default.
- W4385705909 isParatext "false" @default.
- W4385705909 isRetracted "false" @default.
- W4385705909 workType "article" @default.