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• W4385707788 abstract "Abstract Background: The potential relationship between IBD and COPD remains uncertain. necessitating further exploration of their causal relationship. To address this, we employed Mendelian randomization in the present study to investigate the potential causal link between IBD and COPD and provide valuable insights into their interconnectedness. Methods: We performed a comprehensive two-sample Mendelian randomization analysis utilizing extensive genetic summary data obtained from genome-wide association studies (GWAS).Our study utilized a comprehensive dataset comprising a substantial cohort, including 12,366 ulcerative colitis (UC) cases and 33,609 controls, 25,042 IBD cases and 34,915 controls, and 12,194 Crohn's disease (CD) cases and 28,072 controls. The COPD dataset consisted of 58,925 individuals from various GWAS studies. Our main analyses utilized the IVW method with a random-effects model, complemented by WME and MR-Egger approaches. Results: Our study demonstrated a significant correlation between genetic predisposition to IBDand the risk of developing COPD, as evidenced by the IVW(odds ratio [OR] = 1.02, 95% CI = 1.00-1.04, p = 0.013). Consistent results were obtained using the WME (OR = 1.02, 95% CI = 1.00-1.04, p = 0.032) and MR-Egger (OR = 1.02, 95% CI = 1.00-1.04, p = 0.032) methods. Importantly, our analysis did not reveal any evidence of directional pleiotropy between IBD and rosacea, as confirmed by both funnel plots and MR-Egger intercepts. Subgroup analysis further indicated a robust association between Crohn's disease (CD) and rosacea (IVW: OR = 1.01, 95% CI = 1.00-1.02, p = 0.008), while the causal association between ulcerative colitis (UC) and rosacea did not reach statistical significance (IVW: OR = 1.01, 95% CI = 0.99-1.02, p = 0.169). These findings provide compelling evidence supporting the link between IBD and COPD, shedding light on potential pathogenic mechanisms underlying these conditions. Conclusions: Our comprehensive MR analysis provides robust evidence of a unidirectional positive association between IBD and COPD, with varying degrees of association observed among different subtypes of IBD. Notably, variations in the SMAD3 gene may play a pivotal role in the increased risk of COPD among individuals with IBD. Recognizing the elevated occurrence of COPD in IBD patients holds significant clinical implications, highlighting the importance of early identification, monitoring, patient education, preventive measures, and collaborative treatment approaches involving healthcare professionals. The TGF-β1/SMAD3 pathway could serve as a promising therapeutic target for managing IBD complicated with COPD." @default.
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• W4385707788 date "2023-08-09" @default.
• W4385707788 modified "2023-09-25" @default.
• W4385707788 title "Inflammatory bowel disease may increase the risk of COPD: a two-sample Mendelian randomization study" @default.
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• W4385707788 doi "https://doi.org/10.21203/rs.3.rs-3167883/v1" @default.
• W4385707788 hasPublicationYear "2023" @default.
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