FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385708772> ?p ?o ?g. }

• W4385708772 endingPage "2040" @default.
• W4385708772 startingPage "2040" @default.
• W4385708772 abstract "Inactivated whole-cell vaccines present a full repertoire of antigens to the immune system. Formalin treatment, a standard method for microbial inactivation, can modify or destroy protein antigenic epitopes. We tested the hypothesis that photochemical inactivation with psoralen and UVA light (PUVA), which targets nucleic acid, would improve the immunogenicity of an Enterotoxigenic E. coli (ETEC) vaccine relative to a formalin-inactivated counterpart. Exposure of ETEC H10407 to PUVA using the psoralen drug 4′-Aminomethyltrioxsalen hydrochloride (AMT) yielded replication-incompetent bacteria that retained their metabolic activity. CFA/I-mediated mannose-resistant hemagglutination (MRHA) was equivalent for PUVA-inactivated and live ETEC, but was severely reduced for formalin–ETEC, indicating that PUVA preserved fimbrial protein functional integrity. The immunogenicity of PUVA–ETEC and formalin–ETEC was compared in mice ± double mutant heat-labile enterotoxin (dmLT) adjuvant. Two weeks after an intramuscular prime/boost, serum anti-ETEC IgG titers were similar for the two vaccines and were increased by dmLT. However, the IgG responses raised against several conserved ETEC proteins were greater after vaccination with PUVA–ETEC. In addition, PUVA–ETEC generated IgG specific for heat-labile toxin (LT) in the absence of dmLT, which was not a property of formalin–ETEC. These data are consistent with PUVA preserving ETEC protein antigens in their native-like form and justify the further testing of PUVA as a vaccine platform for ETEC using murine challenge models." @default.
• W4385708772 created "2023-08-10" @default.
• W4385708772 creator A5012647186 @default.
• W4385708772 creator A5028774301 @default.
• W4385708772 creator A5035755768 @default.
• W4385708772 creator A5039969118 @default.
• W4385708772 creator A5055931502 @default.
• W4385708772 creator A5084837654 @default.
• W4385708772 creator A5089769333 @default.
• W4385708772 date "2023-08-09" @default.
• W4385708772 modified "2023-09-26" @default.
• W4385708772 title "The Immunogenicity and Properties of a Whole-Cell ETEC Vaccine Inactivated with Psoralen and UVA Light in Comparison to Formalin" @default.
• W4385708772 cites W1108951944 @default.
• W4385708772 cites W1821981622 @default.
• W4385708772 cites W1896878106 @default.
• W4385708772 cites W1901508837 @default.
• W4385708772 cites W1951197670 @default.
• W4385708772 cites W1965770299 @default.
• W4385708772 cites W1969057685 @default.
• W4385708772 cites W1980518589 @default.
• W4385708772 cites W1993809002 @default.
• W4385708772 cites W1996795202 @default.
• W4385708772 cites W1998953165 @default.
• W4385708772 cites W2010025995 @default.
• W4385708772 cites W2014170713 @default.
• W4385708772 cites W2018862317 @default.
• W4385708772 cites W2021838987 @default.
• W4385708772 cites W2024695559 @default.
• W4385708772 cites W2028055910 @default.
• W4385708772 cites W2029928269 @default.
• W4385708772 cites W2044971646 @default.
• W4385708772 cites W2055651797 @default.
• W4385708772 cites W2064720253 @default.
• W4385708772 cites W2067763619 @default.
• W4385708772 cites W2068013575 @default.
• W4385708772 cites W2080028075 @default.
• W4385708772 cites W2088172410 @default.
• W4385708772 cites W2094121535 @default.
• W4385708772 cites W2097143198 @default.
• W4385708772 cites W2101196295 @default.
• W4385708772 cites W2114053580 @default.
• W4385708772 cites W2120440768 @default.
• W4385708772 cites W2121564455 @default.
• W4385708772 cites W2127369887 @default.
• W4385708772 cites W2128024075 @default.
• W4385708772 cites W2133080338 @default.
• W4385708772 cites W2137110369 @default.
• W4385708772 cites W2137174689 @default.
• W4385708772 cites W2137846821 @default.
• W4385708772 cites W2137936579 @default.
• W4385708772 cites W2152242641 @default.
• W4385708772 cites W2156728669 @default.
• W4385708772 cites W2158110726 @default.
• W4385708772 cites W2166463042 @default.
• W4385708772 cites W2171444483 @default.
• W4385708772 cites W2174477839 @default.
• W4385708772 cites W2300018225 @default.
• W4385708772 cites W2335715324 @default.
• W4385708772 cites W2460194971 @default.
• W4385708772 cites W2560748635 @default.
• W4385708772 cites W2791167518 @default.
• W4385708772 cites W2804988832 @default.
• W4385708772 cites W2811305602 @default.
• W4385708772 cites W2885010415 @default.
• W4385708772 cites W2901504310 @default.
• W4385708772 cites W2911543065 @default.
• W4385708772 cites W2989985503 @default.
• W4385708772 cites W2991394462 @default.
• W4385708772 cites W3010770126 @default.
• W4385708772 cites W3080149860 @default.
• W4385708772 cites W3175269210 @default.
• W4385708772 cites W4205696221 @default.
• W4385708772 cites W4220690711 @default.
• W4385708772 cites W4318587902 @default.
• W4385708772 doi "https://doi.org/10.3390/microorganisms11082040" @default.
• W4385708772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37630600" @default.
• W4385708772 hasPublicationYear "2023" @default.
• W4385708772 type Work @default.
• W4385708772 citedByCount "0" @default.
• W4385708772 crossrefType "journal-article" @default.
• W4385708772 hasAuthorship W4385708772A5012647186 @default.
• W4385708772 hasAuthorship W4385708772A5028774301 @default.
• W4385708772 hasAuthorship W4385708772A5035755768 @default.
• W4385708772 hasAuthorship W4385708772A5039969118 @default.
• W4385708772 hasAuthorship W4385708772A5055931502 @default.
• W4385708772 hasAuthorship W4385708772A5084837654 @default.
• W4385708772 hasAuthorship W4385708772A5089769333 @default.
• W4385708772 hasBestOaLocation W43857087721 @default.
• W4385708772 hasConcept C104317684 @default.
• W4385708772 hasConcept C147483822 @default.
• W4385708772 hasConcept C159047783 @default.
• W4385708772 hasConcept C203014093 @default.
• W4385708772 hasConcept C2777871010 @default.
• W4385708772 hasConcept C2780868878 @default.
• W4385708772 hasConcept C2781110370 @default.
• W4385708772 hasConcept C547475151 @default.
• W4385708772 hasConcept C552990157 @default.
• W4385708772 hasConcept C55493867 @default.

• next