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- W4385708776 abstract "Abnormal immune responses are involved in the development of endometriosis (EM). We hope to evaluate the expression and roles of TIGIT and CD226 on CD8+ T cells in EM patients. We included 33 EM patients and 35 controls, detected the proportion of different peripheral CD8+ T cell subsets divided by TIGIT and CD226 by flow cytometry, and evaluated the effect function by CD107a, TNF-α and IFN-γ before and after blocking TIGIT and CD226. We found the proportion of TIGIT on CD8+ in EM patients (31.84 ± 8.49%) was significantly higher than in the control group (27.74 ± 6.70%), P < 0.05, while the proportion of CD226 in the two groups showed no significant difference (79.60 ± 6.73% vs. 81.91 ± 6.60%, P > 0.05). The TIGIT+CD226+CD8+ T-cell subset showed an increased proportion, whereas the TIGIT-CD226+CD8+ T-cell subset decreased in the EM group. The expression of TNF-α and IFN-γ in the CD226+ subset was significantly higher than that in the CD226- subset, while there were opposite changes in the TIGIT+ and TIGIT- subsets. The TIGIT+CD226+CD8+ T cell subset in EM patients with infertility showed a higher proportion (35.13 ± 4.51%) than that in EM patients with fertility (29.75 ± 5.81%, P < 0.05). These findings support our novel hypothesis that the TIGIT+CD226+CD8+ T cell subset showes a higher proportion in EM patients, with lower efficacy than the TIGIT-CD226+CD8+ T cell subset, which could be a potential marker for ancillary diagnosis or understanding of EM." @default.
- W4385708776 created "2023-08-10" @default.
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- W4385708776 date "2023-08-01" @default.
- W4385708776 modified "2023-09-26" @default.
- W4385708776 title "WITHDRAWN: Increased expression of TIGIT+ CD226+ CD8+ T cells in endometriosis patients" @default.
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- W4385708776 doi "https://doi.org/10.1016/j.jri.2023.104131" @default.
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