Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385715246> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4385715246 abstract "Next-generation sequencing (NGS) methods have become more commonly performed in clinical and research laboratories.This review summarizes the current laboratory NGS-based diagnostic approaches in pharmacogenomics including targeted multi-gene panel sequencing, whole-exome sequencing (WES), and whole-genome sequencing (WGS).Clinical laboratories perform multiple non-uniform types of pharmacogenetic panels, which can reduce the overall number of single-gene tests to be more cost-efficient. Compared to the targeted multi-gene panels, which are not typically designed to detect novel variants, WES and WGS have a greater potential to identify secondary pharmacogenomic findings, which might be predictive for the pharmacotherapy outcome of different patient settings. WGS overcomes the limitations of WES enabling a more accurate exome-sequencing at appropriate coverage and the sequencing of non-coding regions. Different NGS-based study designs with different test strategies and study populations, varying sample sizes, and distinct analytical and interpretation procedures lead to different identification results of pharmacogenomic variants.The rapid progress in gene sequencing technologies will overcome the clinical and laboratory challenges of WES and WGS. Further high throughput NGS-based pharmacogenomics studies in different populations and patient settings are necessary to expand knowledge about rare functional variants and to enhance translation in clinical practice." @default.
- W4385715246 created "2023-08-11" @default.
- W4385715246 creator A5004108063 @default.
- W4385715246 creator A5007366534 @default.
- W4385715246 creator A5021658947 @default.
- W4385715246 creator A5022065571 @default.
- W4385715246 creator A5028246817 @default.
- W4385715246 creator A5049667621 @default.
- W4385715246 creator A5089564538 @default.
- W4385715246 date "2023-01-01" @default.
- W4385715246 modified "2023-09-24" @default.
- W4385715246 title "The Use of Next-Generation Sequencing in Pharmacogenomics" @default.
- W4385715246 doi "https://doi.org/10.7754/clin.lab.2023.230103" @default.
- W4385715246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37560847" @default.
- W4385715246 hasPublicationYear "2023" @default.
- W4385715246 type Work @default.
- W4385715246 citedByCount "0" @default.
- W4385715246 crossrefType "journal-article" @default.
- W4385715246 hasAuthorship W4385715246A5004108063 @default.
- W4385715246 hasAuthorship W4385715246A5007366534 @default.
- W4385715246 hasAuthorship W4385715246A5021658947 @default.
- W4385715246 hasAuthorship W4385715246A5022065571 @default.
- W4385715246 hasAuthorship W4385715246A5028246817 @default.
- W4385715246 hasAuthorship W4385715246A5049667621 @default.
- W4385715246 hasAuthorship W4385715246A5089564538 @default.
- W4385715246 hasConcept C104317684 @default.
- W4385715246 hasConcept C10590036 @default.
- W4385715246 hasConcept C16671776 @default.
- W4385715246 hasConcept C170734499 @default.
- W4385715246 hasConcept C501734568 @default.
- W4385715246 hasConcept C51679486 @default.
- W4385715246 hasConcept C54355233 @default.
- W4385715246 hasConcept C60644358 @default.
- W4385715246 hasConcept C70721500 @default.
- W4385715246 hasConcept C71924100 @default.
- W4385715246 hasConcept C86803240 @default.
- W4385715246 hasConceptScore W4385715246C104317684 @default.
- W4385715246 hasConceptScore W4385715246C10590036 @default.
- W4385715246 hasConceptScore W4385715246C16671776 @default.
- W4385715246 hasConceptScore W4385715246C170734499 @default.
- W4385715246 hasConceptScore W4385715246C501734568 @default.
- W4385715246 hasConceptScore W4385715246C51679486 @default.
- W4385715246 hasConceptScore W4385715246C54355233 @default.
- W4385715246 hasConceptScore W4385715246C60644358 @default.
- W4385715246 hasConceptScore W4385715246C70721500 @default.
- W4385715246 hasConceptScore W4385715246C71924100 @default.
- W4385715246 hasConceptScore W4385715246C86803240 @default.
- W4385715246 hasIssue "08/2023" @default.
- W4385715246 hasLocation W43857152461 @default.
- W4385715246 hasLocation W43857152462 @default.
- W4385715246 hasOpenAccess W4385715246 @default.
- W4385715246 hasPrimaryLocation W43857152461 @default.
- W4385715246 hasRelatedWork W1983406990 @default.
- W4385715246 hasRelatedWork W1992112438 @default.
- W4385715246 hasRelatedWork W2003746353 @default.
- W4385715246 hasRelatedWork W2054240869 @default.
- W4385715246 hasRelatedWork W2078353200 @default.
- W4385715246 hasRelatedWork W2104595023 @default.
- W4385715246 hasRelatedWork W3024198590 @default.
- W4385715246 hasRelatedWork W3024531100 @default.
- W4385715246 hasRelatedWork W3031411603 @default.
- W4385715246 hasRelatedWork W4385715246 @default.
- W4385715246 hasVolume "69" @default.
- W4385715246 isParatext "false" @default.
- W4385715246 isRetracted "false" @default.
- W4385715246 workType "article" @default.