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• W4385715363 endingPage "384" @default.
• W4385715363 startingPage "373" @default.
• W4385715363 abstract "Herein, we synthesized a lipid-mimicking organic material (PCD_FA) that can surpass the efficacy of lipid-based nanoparticles and demonstrated its potential as a delivery vehicle for various hydrophilic drugs. PCD_FA is a conjugate of pH-sensitive carbon dots (PCDs) and fatty acids (FAs) and has potential applications in several fields owing to various combinations of carbon dots (CDs) and FAs. Similar to phospholipids, PCD-FAs have hydrophilic heads and hydrophobic tails that allow them to self-form nanoparticles (Coposomes) in the aqueous phase. Coposomes can easily combine various hydrophilic head and hydrophobic tail combinations, and several drugs can be encapsulated, or drug release patterns can be controlled according to each property. We analyzed the differences in size, drug loading efficiency, and drug release patterns of Coposomes depending on the type of FAs and characteristics of the encapsulated drugs. Additionally, cell entry and intracellular drug release mechanisms of the Coposomes were identified. The applicability of Coposomes as drug delivery carriers for tumor treatment has been demonstrated in comparison with that of liposomes formulation in tumor-bearing mouse models. Consequently, this study presents possibilities for the synthesis and application of various amphiphilic lipid-mimicking organic materials via the combination of CDs and FAs with various functions." @default.
• W4385715363 created "2023-08-11" @default.
• W4385715363 creator A5023535693 @default.
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• W4385715363 date "2023-09-01" @default.
• W4385715363 modified "2023-10-03" @default.
• W4385715363 title "Nanoparticle platform comprising lipid-tailed pH-sensitive carbon dots with minimal drug loss" @default.
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• W4385715363 doi "https://doi.org/10.1016/j.jconrel.2023.08.008" @default.
• W4385715363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37558052" @default.
• W4385715363 hasPublicationYear "2023" @default.
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