Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385716021> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4385716021 abstract "This study aimed to develop and evaluate triptolide nanoemulsion gels (TP-NE gels) as a transdermal drug delivery system.TP-NE was prepared and optimized via emulsification and the central composite design response surface method. The optimized TP-NE gel was evaluated in vitro and in vivo. TP-NE gel microstructure, in vitro and in vivo pharmacokinetics, and anti-rheumatoid arthritis effects were studied to evaluate the feasibility of its percutaneous administration.The Optimized TP-NE was observed using a Malvern Autosizer Nano ZS 90 inspection system and a transmission electron microscope (TEM). The nanoemulsion had an average size of 162.9 ± 0.281 nm, a polydispersity index of 0.272 ± 0.024, a zeta potential of -30.03 ± 2.01 mV, and mostly spherical and uniform morphology. In addition, the TP-NE gel pharmacokinetics, assessed via a skin-blood two-site synchronous microdialysis, revealed that TP was higher in the skin than in the blood. TP-NE gel is crucial in reducing knee edema, inhibiting inflammation, and treating rheumatoid arthritis by regulating tumor necrosis factor-alpha, interleukin-1β, and -6 levels.The TP-NE gel is a promising local delivery method for rheumatoid arthritis (RA)-associated edema and inflammation and can serve as a prospective platform for percutaneous TP administration." @default.
- W4385716021 created "2023-08-11" @default.
- W4385716021 creator A5030014001 @default.
- W4385716021 creator A5031397811 @default.
- W4385716021 creator A5043499959 @default.
- W4385716021 creator A5079847437 @default.
- W4385716021 creator A5083408391 @default.
- W4385716021 creator A5087085876 @default.
- W4385716021 date "2023-08-08" @default.
- W4385716021 modified "2023-09-27" @default.
- W4385716021 title "Triptolide nanoemulsion gel as a transdermal drug delivery system: preparation, pharmacokinetics, and rheumatoid arthritis evaluation" @default.
- W4385716021 doi "https://doi.org/10.2174/1567201821666230808114519" @default.
- W4385716021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37559533" @default.
- W4385716021 hasPublicationYear "2023" @default.
- W4385716021 type Work @default.
- W4385716021 citedByCount "0" @default.
- W4385716021 crossrefType "journal-article" @default.
- W4385716021 hasAuthorship W4385716021A5030014001 @default.
- W4385716021 hasAuthorship W4385716021A5031397811 @default.
- W4385716021 hasAuthorship W4385716021A5043499959 @default.
- W4385716021 hasAuthorship W4385716021A5079847437 @default.
- W4385716021 hasAuthorship W4385716021A5083408391 @default.
- W4385716021 hasAuthorship W4385716021A5087085876 @default.
- W4385716021 hasConcept C112705442 @default.
- W4385716021 hasConcept C126322002 @default.
- W4385716021 hasConcept C150903083 @default.
- W4385716021 hasConcept C178790620 @default.
- W4385716021 hasConcept C185592680 @default.
- W4385716021 hasConcept C190283241 @default.
- W4385716021 hasConcept C205679159 @default.
- W4385716021 hasConcept C207001950 @default.
- W4385716021 hasConcept C2777077863 @default.
- W4385716021 hasConcept C2777575956 @default.
- W4385716021 hasConcept C2779820397 @default.
- W4385716021 hasConcept C2781164371 @default.
- W4385716021 hasConcept C55493867 @default.
- W4385716021 hasConcept C71924100 @default.
- W4385716021 hasConcept C86803240 @default.
- W4385716021 hasConcept C98274493 @default.
- W4385716021 hasConceptScore W4385716021C112705442 @default.
- W4385716021 hasConceptScore W4385716021C126322002 @default.
- W4385716021 hasConceptScore W4385716021C150903083 @default.
- W4385716021 hasConceptScore W4385716021C178790620 @default.
- W4385716021 hasConceptScore W4385716021C185592680 @default.
- W4385716021 hasConceptScore W4385716021C190283241 @default.
- W4385716021 hasConceptScore W4385716021C205679159 @default.
- W4385716021 hasConceptScore W4385716021C207001950 @default.
- W4385716021 hasConceptScore W4385716021C2777077863 @default.
- W4385716021 hasConceptScore W4385716021C2777575956 @default.
- W4385716021 hasConceptScore W4385716021C2779820397 @default.
- W4385716021 hasConceptScore W4385716021C2781164371 @default.
- W4385716021 hasConceptScore W4385716021C55493867 @default.
- W4385716021 hasConceptScore W4385716021C71924100 @default.
- W4385716021 hasConceptScore W4385716021C86803240 @default.
- W4385716021 hasConceptScore W4385716021C98274493 @default.
- W4385716021 hasLocation W43857160211 @default.
- W4385716021 hasLocation W43857160212 @default.
- W4385716021 hasOpenAccess W4385716021 @default.
- W4385716021 hasPrimaryLocation W43857160211 @default.
- W4385716021 hasRelatedWork W1491964893 @default.
- W4385716021 hasRelatedWork W2004556784 @default.
- W4385716021 hasRelatedWork W2371846262 @default.
- W4385716021 hasRelatedWork W2379311614 @default.
- W4385716021 hasRelatedWork W2388069209 @default.
- W4385716021 hasRelatedWork W2389499335 @default.
- W4385716021 hasRelatedWork W2582907174 @default.
- W4385716021 hasRelatedWork W2753834235 @default.
- W4385716021 hasRelatedWork W2792371826 @default.
- W4385716021 hasRelatedWork W2945264506 @default.
- W4385716021 hasVolume "21" @default.
- W4385716021 isParatext "false" @default.
- W4385716021 isRetracted "false" @default.
- W4385716021 workType "article" @default.