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- W4385717097 abstract "Hepatic ischemia/reperfusion injury (IRI) is a major factor contributing to the failure of hepatic resection and liver transplantation. As part of our ongoing investigation into bioactive compounds derived from fungi, we isolated eight indole alkaloids (1–8) from the endophytic fungus Aspergillus amoenus TJ507. Among these alkaloids, one previously undescribed compound, amoenamide D (1), was identified. The planar structure of 1 was elucidated by extensive spectroscopic analysis, including HRESIMS and NMR spectra. The absolute configuration of 1 was elucidated by using electronic circular dichroism calculations. Notably, in the CoCl2-induced hepatocyte damage model, notoamide Q (3) exhibited significant anti-hypoxia injury activity. Furthermore, in a murine hepatic ischemia/reperfusion injury model, treatment with 3 prevents IRI-induced liver damage and hepatocellular apoptosis. Consequently, 3 might serve as a potential lead compound to prevent hepatic ischemia/reperfusion injury." @default.
- W4385717097 created "2023-08-11" @default.
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- W4385717097 date "2023-08-10" @default.
- W4385717097 modified "2023-10-12" @default.
- W4385717097 title "Bioactive Indole Alkaloid from <i>Aspergillus amoenus</i> TJ507 That Ameliorates Hepatic Ischemia/Reperfusion Injury" @default.
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- W4385717097 doi "https://doi.org/10.1021/acs.jnatprod.3c00251" @default.
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