Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385718276> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4385718276 abstract "Abstract Autophagy is a conserved lysosomal degradation process that has recently been found to be associated with stress-related psychological diseases. However, previous studies have yielded inconsistent results regarding the effects of various stress patterns on autophagy in different brain regions. This discrepancy may arise from differences in autophagy flux across nuclei, the type of stress experienced, and the timing of autophagy assessment after stress exposure. In this study, we assessed autophagy flux in the rat hippocampus (HPC), medial prefrontal cortex (mPFC), and basal lateral amygdala (BLA) by quantifying protein levels of p-ULK1, LC3-I, LC3-II, and p62 via Western blot analysis at 15 min, 30 min, and 60 min following various stress paradigms: restraint stress, foot shock, single corticosterone injection, and chronic corticosterone treatment. We found that: 1) hippocampal autophagy decreased within 1 hour of restraint stress, foot shock, and corticosterone injection, except for a transient increase at 30 min after restraint stress; 2) autophagy increased 1 hour after restraint stress and corticosterone injection but decreased 1 hour after foot shock in mPFC,; 3) In BLA, autophagy increased 1 hour after foot shock and corticosterone injection but decreased 1 hour after restraint stress; 4) Chronic corticosterone increased autophagy in mPFC and BLA but had no effects in HPC. These findings reveal temporally and spatially distinct autophagy flux patterns in the brain within 1 hour of stress exposure. Such dichotomous responses may contribute to the development of stress-related psychological disorders." @default.
- W4385718276 created "2023-08-11" @default.
- W4385718276 creator A5026160597 @default.
- W4385718276 creator A5032474012 @default.
- W4385718276 creator A5055701842 @default.
- W4385718276 creator A5067828944 @default.
- W4385718276 creator A5072697895 @default.
- W4385718276 creator A5089986454 @default.
- W4385718276 date "2023-08-07" @default.
- W4385718276 modified "2023-10-18" @default.
- W4385718276 title "Restraint stress, foot shock and corticosterone differentially alter autophagy in the rat hippocampus, basolateral amygdala and prefrontal cortex" @default.
- W4385718276 cites W1918384196 @default.
- W4385718276 cites W1986875278 @default.
- W4385718276 cites W1997448970 @default.
- W4385718276 cites W202319641 @default.
- W4385718276 cites W2032576926 @default.
- W4385718276 cites W2080272546 @default.
- W4385718276 cites W2087484352 @default.
- W4385718276 cites W2170298556 @default.
- W4385718276 cites W2195398608 @default.
- W4385718276 cites W2469942047 @default.
- W4385718276 cites W2523801216 @default.
- W4385718276 cites W2600595081 @default.
- W4385718276 cites W2751537800 @default.
- W4385718276 cites W2751997089 @default.
- W4385718276 cites W2844320501 @default.
- W4385718276 cites W2882987804 @default.
- W4385718276 cites W2886843122 @default.
- W4385718276 cites W2888775081 @default.
- W4385718276 cites W2904217430 @default.
- W4385718276 cites W2910014756 @default.
- W4385718276 cites W2946235620 @default.
- W4385718276 cites W2982819864 @default.
- W4385718276 cites W3089107115 @default.
- W4385718276 cites W4318938998 @default.
- W4385718276 doi "https://doi.org/10.21203/rs.3.rs-3226378/v1" @default.
- W4385718276 hasPublicationYear "2023" @default.
- W4385718276 type Work @default.
- W4385718276 citedByCount "0" @default.
- W4385718276 crossrefType "posted-content" @default.
- W4385718276 hasAuthorship W4385718276A5026160597 @default.
- W4385718276 hasAuthorship W4385718276A5032474012 @default.
- W4385718276 hasAuthorship W4385718276A5055701842 @default.
- W4385718276 hasAuthorship W4385718276A5067828944 @default.
- W4385718276 hasAuthorship W4385718276A5072697895 @default.
- W4385718276 hasAuthorship W4385718276A5089986454 @default.
- W4385718276 hasBestOaLocation W43857182761 @default.
- W4385718276 hasConcept C126322002 @default.
- W4385718276 hasConcept C134018914 @default.
- W4385718276 hasConcept C148762608 @default.
- W4385718276 hasConcept C169760540 @default.
- W4385718276 hasConcept C169900460 @default.
- W4385718276 hasConcept C190283241 @default.
- W4385718276 hasConcept C203522944 @default.
- W4385718276 hasConcept C2778654844 @default.
- W4385718276 hasConcept C2779144063 @default.
- W4385718276 hasConcept C2780352252 @default.
- W4385718276 hasConcept C2780451725 @default.
- W4385718276 hasConcept C2781161787 @default.
- W4385718276 hasConcept C2781195155 @default.
- W4385718276 hasConcept C55493867 @default.
- W4385718276 hasConcept C71315377 @default.
- W4385718276 hasConcept C71924100 @default.
- W4385718276 hasConcept C86803240 @default.
- W4385718276 hasConceptScore W4385718276C126322002 @default.
- W4385718276 hasConceptScore W4385718276C134018914 @default.
- W4385718276 hasConceptScore W4385718276C148762608 @default.
- W4385718276 hasConceptScore W4385718276C169760540 @default.
- W4385718276 hasConceptScore W4385718276C169900460 @default.
- W4385718276 hasConceptScore W4385718276C190283241 @default.
- W4385718276 hasConceptScore W4385718276C203522944 @default.
- W4385718276 hasConceptScore W4385718276C2778654844 @default.
- W4385718276 hasConceptScore W4385718276C2779144063 @default.
- W4385718276 hasConceptScore W4385718276C2780352252 @default.
- W4385718276 hasConceptScore W4385718276C2780451725 @default.
- W4385718276 hasConceptScore W4385718276C2781161787 @default.
- W4385718276 hasConceptScore W4385718276C2781195155 @default.
- W4385718276 hasConceptScore W4385718276C55493867 @default.
- W4385718276 hasConceptScore W4385718276C71315377 @default.
- W4385718276 hasConceptScore W4385718276C71924100 @default.
- W4385718276 hasConceptScore W4385718276C86803240 @default.
- W4385718276 hasLocation W43857182761 @default.
- W4385718276 hasOpenAccess W4385718276 @default.
- W4385718276 hasPrimaryLocation W43857182761 @default.
- W4385718276 hasRelatedWork W1501306774 @default.
- W4385718276 hasRelatedWork W1979676541 @default.
- W4385718276 hasRelatedWork W1987895660 @default.
- W4385718276 hasRelatedWork W2053967275 @default.
- W4385718276 hasRelatedWork W2054119993 @default.
- W4385718276 hasRelatedWork W2071427571 @default.
- W4385718276 hasRelatedWork W2088994373 @default.
- W4385718276 hasRelatedWork W2148791245 @default.
- W4385718276 hasRelatedWork W2767851849 @default.
- W4385718276 hasRelatedWork W4385718276 @default.
- W4385718276 isParatext "false" @default.
- W4385718276 isRetracted "false" @default.
- W4385718276 workType "article" @default.