Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385719155> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4385719155 abstract "We aimed to verify whether the immune system may represent a source of potential biomarkers for the stratification of immune-mediated necrotizing myopathies (IMNMs) subtypes. A group of 22 patients diagnosed with IMNM [7 with autoantibodies against signal recognition particle (SRP) and 15 against 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR)] and 12 controls were included. A significant preponderance of M1 macrophages was observed in both SRP+ and HMGCR+ muscle samples (p < 0.0001 in SRP+ and p = 0.0316 for HMGCR+ ), with higher values for SRP+ (p = 0.01). Despite the significant increase observed in the expression of TLR4 and all endosomal Toll-like receptors (TLRs) at protein level in IMNM muscle tissue, only TLR7 has been shown considerably upregulated compared to controls at transcript level (p = 0.0026), whereas TLR9 was even decreased (p = 0.0223). Within IMNM subgroups, TLR4 (p = 0.0116) mRNA was significantly increased in SRP+ compared to HMGCR+ patients. Within IMNM group, only IL-7 was differentially expressed between SRP+ and HMGCR+ patients, with higher values in SRP+ patients (p = 0.0468). Overall, innate immunity represents a key player in pathological mechanisms of IMNM. TLR4 and the inflammatory cytokine IL-7 represent potential immune biomarkers able to differentiate between SRP+ and HMGCR+ patients." @default.
- W4385719155 created "2023-08-11" @default.
- W4385719155 creator A5017229584 @default.
- W4385719155 creator A5024553622 @default.
- W4385719155 creator A5032850040 @default.
- W4385719155 creator A5051568799 @default.
- W4385719155 creator A5051671644 @default.
- W4385719155 creator A5073287634 @default.
- W4385719155 creator A5075494523 @default.
- W4385719155 creator A5086665462 @default.
- W4385719155 creator A5089988641 @default.
- W4385719155 creator A5090854664 @default.
- W4385719155 date "2023-08-10" @default.
- W4385719155 modified "2023-10-16" @default.
- W4385719155 title "Toll‐like receptors and IL‐7 as potential biomarkers for immune‐mediated necrotizing myopathies" @default.
- W4385719155 doi "https://doi.org/10.1002/eji.202250326" @default.
- W4385719155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37562045" @default.
- W4385719155 hasPublicationYear "2023" @default.
- W4385719155 type Work @default.
- W4385719155 citedByCount "0" @default.
- W4385719155 crossrefType "journal-article" @default.
- W4385719155 hasAuthorship W4385719155A5017229584 @default.
- W4385719155 hasAuthorship W4385719155A5024553622 @default.
- W4385719155 hasAuthorship W4385719155A5032850040 @default.
- W4385719155 hasAuthorship W4385719155A5051568799 @default.
- W4385719155 hasAuthorship W4385719155A5051671644 @default.
- W4385719155 hasAuthorship W4385719155A5073287634 @default.
- W4385719155 hasAuthorship W4385719155A5075494523 @default.
- W4385719155 hasAuthorship W4385719155A5086665462 @default.
- W4385719155 hasAuthorship W4385719155A5089988641 @default.
- W4385719155 hasAuthorship W4385719155A5090854664 @default.
- W4385719155 hasBestOaLocation W43857191551 @default.
- W4385719155 hasConcept C126322002 @default.
- W4385719155 hasConcept C136449434 @default.
- W4385719155 hasConcept C170493617 @default.
- W4385719155 hasConcept C203014093 @default.
- W4385719155 hasConcept C2776070231 @default.
- W4385719155 hasConcept C2776914184 @default.
- W4385719155 hasConcept C2778690821 @default.
- W4385719155 hasConcept C55493867 @default.
- W4385719155 hasConcept C71924100 @default.
- W4385719155 hasConcept C86803240 @default.
- W4385719155 hasConcept C8891405 @default.
- W4385719155 hasConceptScore W4385719155C126322002 @default.
- W4385719155 hasConceptScore W4385719155C136449434 @default.
- W4385719155 hasConceptScore W4385719155C170493617 @default.
- W4385719155 hasConceptScore W4385719155C203014093 @default.
- W4385719155 hasConceptScore W4385719155C2776070231 @default.
- W4385719155 hasConceptScore W4385719155C2776914184 @default.
- W4385719155 hasConceptScore W4385719155C2778690821 @default.
- W4385719155 hasConceptScore W4385719155C55493867 @default.
- W4385719155 hasConceptScore W4385719155C71924100 @default.
- W4385719155 hasConceptScore W4385719155C86803240 @default.
- W4385719155 hasConceptScore W4385719155C8891405 @default.
- W4385719155 hasLocation W43857191551 @default.
- W4385719155 hasLocation W43857191552 @default.
- W4385719155 hasOpenAccess W4385719155 @default.
- W4385719155 hasPrimaryLocation W43857191551 @default.
- W4385719155 hasRelatedWork W1495541589 @default.
- W4385719155 hasRelatedWork W1987802636 @default.
- W4385719155 hasRelatedWork W2066136773 @default.
- W4385719155 hasRelatedWork W2088215039 @default.
- W4385719155 hasRelatedWork W2158827209 @default.
- W4385719155 hasRelatedWork W2190283986 @default.
- W4385719155 hasRelatedWork W2316042956 @default.
- W4385719155 hasRelatedWork W2565121077 @default.
- W4385719155 hasRelatedWork W4285733331 @default.
- W4385719155 hasRelatedWork W581377774 @default.
- W4385719155 isParatext "false" @default.
- W4385719155 isRetracted "false" @default.
- W4385719155 workType "article" @default.