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• W4385721788 abstract "BACKGROUND CONTEXTIntraoperative neuromonitoring (IONM) during surgical correction of spinal deformity has been shown to reduce iatrogenic injury in pediatric and adult populations. Although motor-evoked potentials (MEP), somatosensory-evoked potentials (SSEP), and electromyography (EMG) have been shown to be highly sensitive and specific in detecting spinal cord and nerve root injuries, their utility in detecting motor and sensory nerve root injury in pediatric high-grade spondylolisthesis (HGS) remains unknown.PURPOSEWe aim to assess the diagnostic accuracy and therapeutic impact of unimodal and multimodal IONM in the surgical management of HGS.STUDY DESIGN/SETTINGRetrospective cohort study.PATIENT SAMPLEPediatric patients undergoing posterior spinal fusion (PSF) for treatment of HGS.Outcome MeasuresData on patient demographics, spinopelvic and spondylolisthesis parameters, and the presence of pre-and postoperative neurological deficits were collected.METHODSIntraoperative MEP, SSEP, and EMG alerts were recorded. Alert criteria were defined as a change in amplitude of more than 50% for MEP and/or SSEP, with or without change in latency, and more than 10 seconds of sustained EMG activity. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated for each modality and the combination of MEP and SSEP. The 95% confidence intervals (CIs) were calculated using the exact (Clopper-Pearson) method.RESULTSFifty-four pediatric patients with HGS undergoing PSF between 2003 and 2021 in a single tertiary center were included. Seventy-two percent (39/54) of patients were female; the average age of patients was 13.7±2.3 years. The sensitivity of MEP in detecting new postoperative neurologic deficit was 92.3% (95% CI [64.0–99.8]), SSEP 77.8% (95% CI [40.0–97.2]), EMG 69.2% (95% CI [38.6–90.9]), and combination MEP and SSEP 100% (95% CI [73.5–100]). The specificity of MEP was 80.0% (95% CI [64.4–91.0]), SSEP 95.1% (95% CI [83.5–99.4]), EMG 65.9% (95% CI [49.4–79.9]), and combination MEP and SSEP 82.9% (95% CI [67.9–92.9]). The accuracy of SSEP was 92.0% (95% CI [80.8%–97.8%]), and the combination of MEP and SSEP was 86.8% (95% CI [74.7%–94.5%]). Twelve (22.2%) patients had a new motor or sensory deficit diagnosed immediately postoperatively. Nine patients made a full recovery, and 3 had some neurologic deficit on final follow-up.CONCLUSIONUnimodal IONM using SSEP and MEP alone were accurate in diagnosing sensory and motor nerve root injuries, respectively. The diagnostic accuracy in predicting motor and sensory nerve injuries in pediatric HGS improved further with the use of multimodal IONM (combining MEP and SEP). We recommend the utilization of multimodal IONM in all HGS PSF surgeries." @default.
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• W4385721788 date "2023-08-01" @default.
• W4385721788 modified "2023-10-16" @default.
• W4385721788 title "Utility of intraoperative neurophysiological monitoring in detecting motor and sensory nerve injuries in pediatric high-grade spondylolisthesis" @default.
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• W4385721788 doi "https://doi.org/10.1016/j.spinee.2023.08.002" @default.
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