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- W4385727676 endingPage "625" @default.
- W4385727676 startingPage "609" @default.
- W4385727676 abstract "Abstract Gastrointestinal (GI) complications are seen in over 50% of ischemic stroke survivors; the most common complications are dysphagia, constipation, and GI bleeding. The bidirectional relationship of the gut–brain axis and stroke has recently gained traction, wherein stroke contributes to gut dysbiosis (alterations in the normal host intestinal microbiome) and gut dysbiosis perpetuates poor functional neurologic outcomes in stroke. It is postulated that the propagation of proinflammatory cells and gut metabolites (including trimethylamine N-oxide and short-chain fatty acids) from the GI tract to the central nervous system play a central role in gut–brain axis dysfunction. In this review, we discuss the known GI complications in acute ischemic stroke, our current knowledge from experimental stroke models for gut–brain axis dysfunction in stroke, and emerging therapeutics that target the gut–brain axis." @default.
- W4385727676 created "2023-08-11" @default.
- W4385727676 creator A5027568070 @default.
- W4385727676 creator A5059402979 @default.
- W4385727676 creator A5079696040 @default.
- W4385727676 date "2023-08-01" @default.
- W4385727676 modified "2023-10-14" @default.
- W4385727676 title "Gastrointestinal Dysfunction in Stroke" @default.
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