Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385728260> ?p ?o ?g. }
- W4385728260 endingPage "10491" @default.
- W4385728260 startingPage "10477" @default.
- W4385728260 abstract "Electroencephalography studies link sensory processing issues in schizophrenia to increased noise level-noise here is background spontaneous activity-as measured by the signal-to-noise ratio. The mechanism, however, of such increased noise is unknown. We investigate if this relates to changes in cortical excitation-inhibition balance, which has been observed to be atypical in schizophrenia, by combining electroencephalography and computational modeling. Our electroencephalography task results, for which the local field potentials can be used as a proxy, show lower signal-to-noise ratio due to higher noise in schizophrenia. Both electroencephalography rest and task states exhibit higher levels of excitation in the functional excitation-inhibition (as a proxy of excitation-inhibition balance). This suggests a relationship between increased noise and atypical excitation in schizophrenia, which was addressed by using computational modeling. A Leaky Integrate-and-Fire model was used to simulate the effects of varying degrees of noise on excitation-inhibition balance, local field potential, NMDA current, and . Results show a noise-related increase in the local field potential, excitation in excitation-inhibition balance, pyramidal NMDA current, and spike rate. Mutual information and mediation analysis were used to explore a cross-level relationship, showing that the cortical local field potential plays a key role in transferring the effect of noise to the cellular population level of NMDA." @default.
- W4385728260 created "2023-08-11" @default.
- W4385728260 creator A5021698606 @default.
- W4385728260 creator A5041178190 @default.
- W4385728260 creator A5063977822 @default.
- W4385728260 creator A5076033503 @default.
- W4385728260 date "2023-08-10" @default.
- W4385728260 modified "2023-10-17" @default.
- W4385728260 title "Increased noise relates to abnormal excitation-inhibition balance in schizophrenia: a combined empirical and computational study" @default.
- W4385728260 cites W1525254066 @default.
- W4385728260 cites W1582051163 @default.
- W4385728260 cites W1600495254 @default.
- W4385728260 cites W1963724713 @default.
- W4385728260 cites W1967974614 @default.
- W4385728260 cites W1973275441 @default.
- W4385728260 cites W1976993603 @default.
- W4385728260 cites W1981855363 @default.
- W4385728260 cites W1984141645 @default.
- W4385728260 cites W1985987483 @default.
- W4385728260 cites W1989512479 @default.
- W4385728260 cites W1991726755 @default.
- W4385728260 cites W1994016017 @default.
- W4385728260 cites W1994321338 @default.
- W4385728260 cites W1997418665 @default.
- W4385728260 cites W1999076145 @default.
- W4385728260 cites W2013514700 @default.
- W4385728260 cites W2022961682 @default.
- W4385728260 cites W2049775606 @default.
- W4385728260 cites W2051902390 @default.
- W4385728260 cites W2064569372 @default.
- W4385728260 cites W2070369865 @default.
- W4385728260 cites W2074166433 @default.
- W4385728260 cites W2074985111 @default.
- W4385728260 cites W2082642969 @default.
- W4385728260 cites W2092939357 @default.
- W4385728260 cites W2095578236 @default.
- W4385728260 cites W2102074339 @default.
- W4385728260 cites W2102293491 @default.
- W4385728260 cites W2104057213 @default.
- W4385728260 cites W2113412631 @default.
- W4385728260 cites W2123703395 @default.
- W4385728260 cites W2125386334 @default.
- W4385728260 cites W2125733184 @default.
- W4385728260 cites W2126579241 @default.
- W4385728260 cites W2128156437 @default.
- W4385728260 cites W2128495200 @default.
- W4385728260 cites W2131215403 @default.
- W4385728260 cites W2131856072 @default.
- W4385728260 cites W2136532493 @default.
- W4385728260 cites W2140487181 @default.
- W4385728260 cites W2144994235 @default.
- W4385728260 cites W2146052710 @default.
- W4385728260 cites W2147445408 @default.
- W4385728260 cites W2149618862 @default.
- W4385728260 cites W2155677028 @default.
- W4385728260 cites W2160976872 @default.
- W4385728260 cites W2161983882 @default.
- W4385728260 cites W2162246060 @default.
- W4385728260 cites W2163922059 @default.
- W4385728260 cites W2169345222 @default.
- W4385728260 cites W2170946434 @default.
- W4385728260 cites W2184278584 @default.
- W4385728260 cites W2565235170 @default.
- W4385728260 cites W2597800943 @default.
- W4385728260 cites W2766712554 @default.
- W4385728260 cites W2792717260 @default.
- W4385728260 cites W2795334944 @default.
- W4385728260 cites W2810939025 @default.
- W4385728260 cites W2915805767 @default.
- W4385728260 cites W2917501693 @default.
- W4385728260 cites W2945129130 @default.
- W4385728260 cites W3015253738 @default.
- W4385728260 cites W3015976665 @default.
- W4385728260 cites W3033819379 @default.
- W4385728260 cites W3097044977 @default.
- W4385728260 cites W3111066986 @default.
- W4385728260 cites W3131078466 @default.
- W4385728260 cites W3145259152 @default.
- W4385728260 cites W3159456120 @default.
- W4385728260 cites W3163985362 @default.
- W4385728260 cites W3165692674 @default.
- W4385728260 cites W3175236521 @default.
- W4385728260 cites W3187158353 @default.
- W4385728260 cites W3197222283 @default.
- W4385728260 cites W4200572908 @default.
- W4385728260 cites W4214834451 @default.
- W4385728260 cites W4220674095 @default.
- W4385728260 cites W4220833196 @default.
- W4385728260 cites W4224238307 @default.
- W4385728260 cites W4238614602 @default.
- W4385728260 cites W4250543537 @default.
- W4385728260 cites W4293721130 @default.
- W4385728260 cites W4294281159 @default.
- W4385728260 cites W4295009363 @default.
- W4385728260 doi "https://doi.org/10.1093/cercor/bhad297" @default.
- W4385728260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37562844" @default.
- W4385728260 hasPublicationYear "2023" @default.
- W4385728260 type Work @default.