FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385728832> ?p ?o ?g. }

• W4385728832 abstract "Abstract Recent studies have shown that phosphoglycerate kinase 1 (PGK1) may improve neurodegeneration. However, the role of PGK1 in acrylamide(ACR)-induced neuronal damage is not yet clear. In this study, SD rats were treated with 6 mg/kg and 18 mg/kg of ACR, and PC12 cells were treated with 1.25 mM and 2.5 mM of ACR, and PC12 cells were transfected with PGK1 siRNA. Behavioral responses and histopathological changes in the rats were monitored, and transmission electron microscopy was used to observe changes in neurons and internal organelles in the hippocampal tissues of the various groups. Western blot and RT-qPCR were used to detect changes in the expression of neuronal-related proteins BDNF, Syn1, Nrf2 signaling pathway-related proteins and PGK1 in the hippocampal tissues of the rats and PC12 cells. Immunohistochemistry and immunofluorescence were used to analyze PGK1 expression in the hippocampal tissues of the rats. The results showed that after ACR treatment, obvious hindlimb clasping effect was observed in rats, hippocampal tissue pathology occurred, neuronal boundaries became blurred, mitochondria swelled, and organelles became sparse. BDNF and Syn1 mRNA expression and protein levels decreased both in vivo and in vitro , while Nrf2 and PGK1 mRNA expression and protein levels increased both in vivo and in vitro . In PC12 cells, inhibition of PGK1 can alleviate cell damage, and increase the expression of BDNF and Syn1 while Nrf2 expression is suppressed. These results suggest that inhibiting the expression of PGK1 can protect nerve cell damage induced by ACR." @default.
• W4385728832 created "2023-08-11" @default.
• W4385728832 creator A5012879254 @default.
• W4385728832 creator A5016724302 @default.
• W4385728832 creator A5048507878 @default.
• W4385728832 creator A5051911719 @default.
• W4385728832 creator A5060353579 @default.
• W4385728832 creator A5062064525 @default.
• W4385728832 creator A5071091495 @default.
• W4385728832 creator A5071705905 @default.
• W4385728832 creator A5076825972 @default.
• W4385728832 creator A5086532638 @default.
• W4385728832 creator A5087099599 @default.
• W4385728832 date "2023-08-08" @default.
• W4385728832 modified "2023-09-27" @default.
• W4385728832 title "Inhibiting the expression of PGK1 can improve the damage of nerve cells caused by acrylamide" @default.
• W4385728832 cites W1974476511 @default.
• W4385728832 cites W1985372920 @default.
• W4385728832 cites W1991716924 @default.
• W4385728832 cites W2000373019 @default.
• W4385728832 cites W2000503562 @default.
• W4385728832 cites W2005482288 @default.
• W4385728832 cites W2005845391 @default.
• W4385728832 cites W2096000363 @default.
• W4385728832 cites W2135228248 @default.
• W4385728832 cites W2340338776 @default.
• W4385728832 cites W2519850890 @default.
• W4385728832 cites W2530607281 @default.
• W4385728832 cites W2585071503 @default.
• W4385728832 cites W2741411818 @default.
• W4385728832 cites W2779339038 @default.
• W4385728832 cites W2884876534 @default.
• W4385728832 cites W2922784032 @default.
• W4385728832 cites W2973064436 @default.
• W4385728832 cites W3001981838 @default.
• W4385728832 cites W3003757683 @default.
• W4385728832 cites W3004443958 @default.
• W4385728832 cites W3037752736 @default.
• W4385728832 cites W3118681762 @default.
• W4385728832 cites W3129262496 @default.
• W4385728832 cites W3134883985 @default.
• W4385728832 cites W3143499685 @default.
• W4385728832 cites W3163926802 @default.
• W4385728832 cites W3172303638 @default.
• W4385728832 cites W4200050093 @default.
• W4385728832 cites W4206762599 @default.
• W4385728832 cites W4220713068 @default.
• W4385728832 cites W4223507121 @default.
• W4385728832 cites W4223541971 @default.
• W4385728832 cites W4224306265 @default.
• W4385728832 cites W4225277770 @default.
• W4385728832 cites W4289134955 @default.
• W4385728832 cites W4291014971 @default.
• W4385728832 cites W4311871304 @default.
• W4385728832 doi "https://doi.org/10.21203/rs.3.rs-3226297/v1" @default.
• W4385728832 hasPublicationYear "2023" @default.
• W4385728832 type Work @default.
• W4385728832 citedByCount "0" @default.
• W4385728832 crossrefType "posted-content" @default.
• W4385728832 hasAuthorship W4385728832A5012879254 @default.
• W4385728832 hasAuthorship W4385728832A5016724302 @default.
• W4385728832 hasAuthorship W4385728832A5048507878 @default.
• W4385728832 hasAuthorship W4385728832A5051911719 @default.
• W4385728832 hasAuthorship W4385728832A5060353579 @default.
• W4385728832 hasAuthorship W4385728832A5062064525 @default.
• W4385728832 hasAuthorship W4385728832A5071091495 @default.
• W4385728832 hasAuthorship W4385728832A5071705905 @default.
• W4385728832 hasAuthorship W4385728832A5076825972 @default.
• W4385728832 hasAuthorship W4385728832A5086532638 @default.
• W4385728832 hasAuthorship W4385728832A5087099599 @default.
• W4385728832 hasBestOaLocation W43857288321 @default.
• W4385728832 hasConcept C104317684 @default.
• W4385728832 hasConcept C134018914 @default.
• W4385728832 hasConcept C148762608 @default.
• W4385728832 hasConcept C150903083 @default.
• W4385728832 hasConcept C153911025 @default.
• W4385728832 hasConcept C168240541 @default.
• W4385728832 hasConcept C185592680 @default.
• W4385728832 hasConcept C202751555 @default.
• W4385728832 hasConcept C207001950 @default.
• W4385728832 hasConcept C2776415932 @default.
• W4385728832 hasConcept C2781161787 @default.
• W4385728832 hasConcept C55493867 @default.
• W4385728832 hasConcept C85265743 @default.
• W4385728832 hasConcept C86803240 @default.
• W4385728832 hasConcept C95444343 @default.
• W4385728832 hasConceptScore W4385728832C104317684 @default.
• W4385728832 hasConceptScore W4385728832C134018914 @default.
• W4385728832 hasConceptScore W4385728832C148762608 @default.
• W4385728832 hasConceptScore W4385728832C150903083 @default.
• W4385728832 hasConceptScore W4385728832C153911025 @default.
• W4385728832 hasConceptScore W4385728832C168240541 @default.
• W4385728832 hasConceptScore W4385728832C185592680 @default.
• W4385728832 hasConceptScore W4385728832C202751555 @default.
• W4385728832 hasConceptScore W4385728832C207001950 @default.
• W4385728832 hasConceptScore W4385728832C2776415932 @default.
• W4385728832 hasConceptScore W4385728832C2781161787 @default.
• W4385728832 hasConceptScore W4385728832C55493867 @default.
• W4385728832 hasConceptScore W4385728832C85265743 @default.
• W4385728832 hasConceptScore W4385728832C86803240 @default.

• next