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• W4385729265 abstract "Background Typical absence seizures (TAS) are seen in idiopathic generalized epilepsy. EEG contributes to syndrome characterization and counselling in an area where genetics do not currently play a significant role. Prominent interictal EEG findings are seen in Juvenile absence epilepsy and are thus thought to be associated with less favorable outcome in any TAS case despite a lack of studies to prove this. Our study evaluates EEG findings and their association with seizure outcomes in children with TAS. Methods This is a retrospective cohort study of 123 children over ten years with extensive EEG analysis and medical record review. Phone interviews ascertained longer-term outcomes. EEG reviewers were blinded to outcomes. Results Total cohort included 123 children with phone review completed in 98. Median follow-up was 5years 9months. Seizure freedom was seen in 59% off anti-seizure medicines (ASM). Interictal findings included focal discharges in 29%, fragments of spike-wave (SW) discharges in 82.1%, and generalized interictal discharges in 63.4%. Interictal SW was more likely in those who slept (100%,18/18) versus those who did not (57%,60/105)(p<0.001). Outcome analysis found no associations between focal or generalized interictal findings and seizure freedom, relapse off ASM, occurrence of other seizure types, or response to first ASM. Significance Focal and generalized interictal EEG discharges are common in children with TAS and are not associated with poorer seizure outcomes. These interictal findings have traditionally been associated with JAE rather than CAE and were thus believed to be associated with potentially poorer outcome which is probably not the case." @default.
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• W4385729265 date "2023-11-01" @default.
• W4385729265 modified "2023-10-10" @default.
• W4385729265 title "Relationship Between Electroencephalography and Seizure Outcome in Typical Absence Seizures in Children" @default.
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• W4385729265 doi "https://doi.org/10.1016/j.pediatrneurol.2023.08.004" @default.
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