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- W4385737776 endingPage "5997" @default.
- W4385737776 startingPage "5997" @default.
- W4385737776 abstract "Cancer is one of the leading causes of death worldwide, and its incidence and mortality are increasing each year. Improved therapeutic strategies against cancer have progressed, but remain insufficient to invert this trend. Along with several other risk factors, abnormal genetic and epigenetic regulations play a critical role in the initiation of cellular transformation, as well as tumorigenesis. The epigenetic regulator UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is a multidomain protein with oncogenic abilities overexpressed in most cancers. Through the coordination of its multiple domains and other epigenetic key players, UHRF1 regulates DNA methylation and histone modifications. This well-coordinated dialogue leads to the silencing of tumor-suppressor genes (TSGs) and facilitates tumor cells’ resistance toward anticancer drugs, ultimately promoting apoptosis escape and uncontrolled proliferation. Several studies have shown that the downregulation of UHRF1 with natural compounds in tumor cells induces the reactivation of various TSGs, inhibits cell growth, and promotes apoptosis. In this review, we discuss the underlying mechanisms and the potential of various natural and synthetic compounds that can inhibit/minimize UHRF1’s oncogenic activities and/or its expression." @default.
- W4385737776 created "2023-08-11" @default.
- W4385737776 creator A5019665090 @default.
- W4385737776 creator A5032024453 @default.
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- W4385737776 creator A5056966415 @default.
- W4385737776 creator A5057462377 @default.
- W4385737776 creator A5069402455 @default.
- W4385737776 date "2023-08-10" @default.
- W4385737776 modified "2023-09-26" @default.
- W4385737776 title "Natural and Synthetic Anticancer Epidrugs Targeting the Epigenetic Integrator UHRF1" @default.
- W4385737776 cites W1503871230 @default.
- W4385737776 cites W1554300113 @default.
- W4385737776 cites W1563927977 @default.
- W4385737776 cites W1577161975 @default.
- W4385737776 cites W1608553039 @default.
- W4385737776 cites W1751741427 @default.
- W4385737776 cites W1785580848 @default.
- W4385737776 cites W1964114393 @default.
- W4385737776 cites W1965195498 @default.
- W4385737776 cites W1965262464 @default.
- W4385737776 cites W1969561477 @default.
- W4385737776 cites W1971799791 @default.
- W4385737776 cites W1971978509 @default.
- W4385737776 cites W1972318805 @default.
- W4385737776 cites W1975375696 @default.
- W4385737776 cites W1977063334 @default.
- W4385737776 cites W1977136985 @default.
- W4385737776 cites W1988102584 @default.
- W4385737776 cites W1996238004 @default.
- W4385737776 cites W1996986554 @default.
- W4385737776 cites W1998137132 @default.
- W4385737776 cites W2000204195 @default.
- W4385737776 cites W2003314433 @default.
- W4385737776 cites W2004391000 @default.
- W4385737776 cites W2006410633 @default.
- W4385737776 cites W2006696807 @default.
- W4385737776 cites W2009951446 @default.
- W4385737776 cites W2017996739 @default.
- W4385737776 cites W2018216425 @default.
- W4385737776 cites W2027583609 @default.
- W4385737776 cites W2028956307 @default.
- W4385737776 cites W2030775866 @default.
- W4385737776 cites W2037844128 @default.
- W4385737776 cites W2039056262 @default.
- W4385737776 cites W2051248464 @default.
- W4385737776 cites W2051899483 @default.
- W4385737776 cites W2056653443 @default.
- W4385737776 cites W2057134657 @default.
- W4385737776 cites W2057964641 @default.
- W4385737776 cites W2059890127 @default.
- W4385737776 cites W2061036769 @default.
- W4385737776 cites W2062216744 @default.
- W4385737776 cites W2063673269 @default.
- W4385737776 cites W2064522668 @default.
- W4385737776 cites W2075222802 @default.
- W4385737776 cites W2075459950 @default.
- W4385737776 cites W2076257956 @default.
- W4385737776 cites W2080332548 @default.
- W4385737776 cites W2080515794 @default.
- W4385737776 cites W2082839760 @default.
- W4385737776 cites W2084486586 @default.
- W4385737776 cites W2093576033 @default.
- W4385737776 cites W2094127881 @default.
- W4385737776 cites W2096330673 @default.
- W4385737776 cites W2099407732 @default.
- W4385737776 cites W2100281006 @default.
- W4385737776 cites W2108444776 @default.
- W4385737776 cites W2113496316 @default.
- W4385737776 cites W2121271487 @default.
- W4385737776 cites W2122806056 @default.
- W4385737776 cites W2131259072 @default.
- W4385737776 cites W2131612302 @default.
- W4385737776 cites W2131648255 @default.
- W4385737776 cites W2136492640 @default.
- W4385737776 cites W2136745780 @default.
- W4385737776 cites W2142745453 @default.
- W4385737776 cites W2146784968 @default.
- W4385737776 cites W2153381101 @default.
- W4385737776 cites W2153988674 @default.
- W4385737776 cites W2155504720 @default.
- W4385737776 cites W2161097917 @default.
- W4385737776 cites W2164957407 @default.
- W4385737776 cites W2169373040 @default.
- W4385737776 cites W2170570748 @default.
- W4385737776 cites W2171620999 @default.
- W4385737776 cites W2181051316 @default.
- W4385737776 cites W2267841403 @default.
- W4385737776 cites W2273829551 @default.
- W4385737776 cites W2284352995 @default.
- W4385737776 cites W2313088239 @default.
- W4385737776 cites W2479776107 @default.
- W4385737776 cites W2485513414 @default.
- W4385737776 cites W2552964531 @default.
- W4385737776 cites W2565427575 @default.
- W4385737776 cites W2567819266 @default.
- W4385737776 cites W2581449600 @default.