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- W4385737890 abstract "Abstract Background We lack a reliable indicator of vascular disease activity in Juvenile Dermatomyositis (JDM), a rare disease. The goal of this study is to identify the association of nailfold capillary End Row Loop (ERL) loss with vascular damage in children with newly diagnosed, untreated JDM. Findings : We enrolled 140 untreated JDM and matched healthy controls, ages 2–17. We selected items from the Juvenile Myositis Registry for analysis. Variables include average ERL density of 8 fingers, average capillary pattern, hemorrhages, and clinical and laboratory correlates. Laboratory data includes Myositis Specific Antibodies (MSA), disease activity scores (DAS), Childhood Myositis Assessment Scale (CMAS), and standard clinical serologic data. The reduced mean ERL density is 5.1 ± 1.5/mm for untreated JDM vs 7.9 ± 0.9/mm for healthy controls, p < 0.0001, and is associated with DAS-skin, r=-0.27 p = 0.014, which did not change within the age range tested. Untreated JDM with MSA Tif-1-γ had the lowest ERL density, (p = 0.037); their ERL patterns were primarily “open”. In addition, we found that hemorrhages in the nailfold were associated with dysphagia (p = 0.004). Conclusions Nailfold data reflects vascular disease in untreated children with JDM. Decreased JDM ERL density is associated with increased vascular damage. We speculate ERL density appears to be an useful indicator of vascular disease activity in untreated children with JDM." @default.
- W4385737890 created "2023-08-11" @default.
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- W4385737890 date "2023-08-10" @default.
- W4385737890 modified "2023-09-27" @default.
- W4385737890 title "Nailfold Capillary Density in 140 Untreated Children With Juvenile Dermatomyositis: An Indicator of Vascular Disease Activity" @default.
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- W4385737890 doi "https://doi.org/10.21203/rs.3.rs-3221979/v1" @default.
- W4385737890 hasPublicationYear "2023" @default.
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