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• W4385737993 endingPage "2037" @default.
• W4385737993 startingPage "2037" @default.
• W4385737993 abstract "RECQ5, a member of the conserved RECQ helicase family, is the sole human RECQ homolog that has not been linked to a hereditary developmental syndrome. Nonetheless, dysregulation of RECQ5 has emerged as a significant clinical concern, being linked to cancer predisposition, cardiovascular disease, and inflammation. In cells, RECQ5 assumes a crucial role in the regulation of DNA repair pathways, particularly in the repair of DNA double-strand breaks and inter-strand DNA crosslinks. Moreover, RECQ5 exhibits a capacity to modulate gene expression by interacting with transcription machineries and their co-regulatory proteins, thus safeguarding against transcription-induced DNA damage. This review aims to provide an overview of the multifaceted functions of RECQ5 and its implications in maintaining genomic stability. We will discuss the potential effects of clinical variants of RECQ5 on its cellular functions and their underlying mechanisms in the pathogenesis of cancer and cardiovascular disease. We will review the impact of RECQ5 variants in the field of pharmacogenomics, specifically their influence on drug responses, which may pave the way for novel therapeutic interventions targeting RECQ5 in human diseases." @default.
• W4385737993 created "2023-08-11" @default.
• W4385737993 creator A5002480151 @default.
• W4385737993 creator A5005510149 @default.
• W4385737993 creator A5052897824 @default.
• W4385737993 creator A5074801223 @default.
• W4385737993 date "2023-08-10" @default.
• W4385737993 modified "2023-09-26" @default.
• W4385737993 title "Understanding the Human RECQ5 Helicase—Connecting the Dots from DNA to Clinics" @default.
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