Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385751842> ?p ?o ?g. }
- W4385751842 abstract "Abstract Statins are lipid‐lowering drugs that selectively inhibit 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, effectively reducing cholesterol synthesis. With improved nutritional conditions, the demand for statins is increasing in the global market. The use of microbial cell factories for statin biosynthesis has become advantageous due to the rapid advancements in biotechnology. These approaches offer simple operation and easy separation of products. This review provides an overview the strategies for statins production via microbial cell factories, including both traditional fermentation culture (non‐genetic) and modern synthetic biology manufacture (genetic). Firstly, the complex fermentation parameters and process control technology on submerged fermentation (SmF) and solid‐state fermentation (SSF) are introduced in detail. The potential use of recoverable agricultural wastes/(biomass) as a fermentation substrate in SSF for statin production is emphasized. Additionally, metabolic engineering strategies for constructing robust engineering strains and directed evolution are also discussed. The review highlights the potential and challenges of using microbial cell factories for statin production, and aims to promote greener production modes for statins." @default.
- W4385751842 created "2023-08-12" @default.
- W4385751842 creator A5003882350 @default.
- W4385751842 creator A5008135430 @default.
- W4385751842 creator A5050421529 @default.
- W4385751842 creator A5051110035 @default.
- W4385751842 creator A5080024891 @default.
- W4385751842 date "2023-08-17" @default.
- W4385751842 modified "2023-09-28" @default.
- W4385751842 title "Improving statins production: From non‐genetic strategies to genetic strategies" @default.
- W4385751842 cites W1965575554 @default.
- W4385751842 cites W1966490048 @default.
- W4385751842 cites W1967974152 @default.
- W4385751842 cites W1968327442 @default.
- W4385751842 cites W1969226417 @default.
- W4385751842 cites W1980092192 @default.
- W4385751842 cites W1988144542 @default.
- W4385751842 cites W1998015180 @default.
- W4385751842 cites W2016873363 @default.
- W4385751842 cites W2021887886 @default.
- W4385751842 cites W2028540334 @default.
- W4385751842 cites W2029462330 @default.
- W4385751842 cites W2031131152 @default.
- W4385751842 cites W2043301351 @default.
- W4385751842 cites W2057406735 @default.
- W4385751842 cites W2061113126 @default.
- W4385751842 cites W2063006657 @default.
- W4385751842 cites W2070768461 @default.
- W4385751842 cites W2073131803 @default.
- W4385751842 cites W2075319898 @default.
- W4385751842 cites W2076739934 @default.
- W4385751842 cites W2083927054 @default.
- W4385751842 cites W2088390305 @default.
- W4385751842 cites W2088468185 @default.
- W4385751842 cites W2103899638 @default.
- W4385751842 cites W2118992947 @default.
- W4385751842 cites W2125149319 @default.
- W4385751842 cites W2146615847 @default.
- W4385751842 cites W2149202606 @default.
- W4385751842 cites W2149507234 @default.
- W4385751842 cites W2156125238 @default.
- W4385751842 cites W2163086525 @default.
- W4385751842 cites W2166323054 @default.
- W4385751842 cites W2170346758 @default.
- W4385751842 cites W2171699296 @default.
- W4385751842 cites W2175362852 @default.
- W4385751842 cites W2250697541 @default.
- W4385751842 cites W2309704783 @default.
- W4385751842 cites W2332163219 @default.
- W4385751842 cites W2407756794 @default.
- W4385751842 cites W2624828452 @default.
- W4385751842 cites W2773959932 @default.
- W4385751842 cites W2793456710 @default.
- W4385751842 cites W2797503430 @default.
- W4385751842 cites W2891359071 @default.
- W4385751842 cites W2893443076 @default.
- W4385751842 cites W2922511320 @default.
- W4385751842 cites W2931707546 @default.
- W4385751842 cites W2937964901 @default.
- W4385751842 cites W2943677637 @default.
- W4385751842 cites W2950501991 @default.
- W4385751842 cites W2962699637 @default.
- W4385751842 cites W2971561091 @default.
- W4385751842 cites W3004243791 @default.
- W4385751842 cites W3010872714 @default.
- W4385751842 cites W3043556022 @default.
- W4385751842 cites W3049652035 @default.
- W4385751842 cites W3085244668 @default.
- W4385751842 cites W3088658852 @default.
- W4385751842 cites W3088972669 @default.
- W4385751842 cites W3177902441 @default.
- W4385751842 cites W3182103873 @default.
- W4385751842 cites W3211655359 @default.
- W4385751842 cites W3216281996 @default.
- W4385751842 cites W4200564382 @default.
- W4385751842 cites W4223967625 @default.
- W4385751842 cites W4368359764 @default.
- W4385751842 cites W61538166 @default.
- W4385751842 doi "https://doi.org/10.1002/biot.202300229" @default.
- W4385751842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37563745" @default.
- W4385751842 hasPublicationYear "2023" @default.
- W4385751842 type Work @default.
- W4385751842 citedByCount "0" @default.
- W4385751842 crossrefType "journal-article" @default.
- W4385751842 hasAuthorship W4385751842A5003882350 @default.
- W4385751842 hasAuthorship W4385751842A5008135430 @default.
- W4385751842 hasAuthorship W4385751842A5050421529 @default.
- W4385751842 hasAuthorship W4385751842A5051110035 @default.
- W4385751842 hasAuthorship W4385751842A5080024891 @default.
- W4385751842 hasBestOaLocation W43857518421 @default.
- W4385751842 hasConcept C100544194 @default.
- W4385751842 hasConcept C127413603 @default.
- W4385751842 hasConcept C139719470 @default.
- W4385751842 hasConcept C150903083 @default.
- W4385751842 hasConcept C162324750 @default.
- W4385751842 hasConcept C181199279 @default.
- W4385751842 hasConcept C183696295 @default.
- W4385751842 hasConcept C191908910 @default.
- W4385751842 hasConcept C2776839432 @default.
- W4385751842 hasConcept C2778348673 @default.