Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385754908> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4385754908 endingPage "055032" @default.
- W4385754908 startingPage "055032" @default.
- W4385754908 abstract "Objective. This work sets out the capabilities of the high energy proton research beamline developed in the Christie proton therapy centre for Ultra-High Dose Rate (UHDR) irradiation and FLASH experiments. It also characterises the lower limits of UHDR operation for this Pencil Beam Scanning (PBS) proton hardware.Approach. Energy dependent nozzle transmission was measured using a Faraday Cup beam collector. Spot size was measured at the reference plane using a 2D scintillation detector. Integrated depth doses (IDDs) were measured. EBT3 Gafchromic film was used to compare UHDR and conventional dose rate spots. Our beam monitor calibration methodolgy for UHDR is described. A microDiamond detector was used to determine dose rates at zref. Instantaneous depth dose rates were calculated for 70-245 MeV. PBS dose rate distributions were calculated using Folkerts and Van der Water definitions.Main results. Transmission of 7.05 ± 0.1% is achieveable corresponding to a peak instantaneous dose rate of 112.7 Gy s-1. Beam parameters are comparable in conventional and UHDR mode with a spot size ofσx= 4.6 mm,σy= 6.6 mm. Dead time in the beam monitoring electonics warrants a beam current dependent MU correction in the present configuration. Fast beam scanning of 26.4 m s-1(X) and 12.1 m s-1(Y) allows PBS dose rates of the order tens of Grays per second.Significance. UHDR delivery is possible for small field sizes and high energies enabling research into the FLASH effect with PBS protons at our facility. To our knowledge this is also the first thorough characterisation of UHDR irradiation using the hardware of this clinical accelerator at energies less than 250 MeV. The data set out in this publication can be used for designing experiments at this UK research facility and inform the possible future clinical translation of UHDR PBS proton therapy." @default.
- W4385754908 created "2023-08-12" @default.
- W4385754908 creator A5002396853 @default.
- W4385754908 creator A5024868123 @default.
- W4385754908 creator A5034350645 @default.
- W4385754908 creator A5046093888 @default.
- W4385754908 creator A5050287039 @default.
- W4385754908 creator A5068022992 @default.
- W4385754908 creator A5080277966 @default.
- W4385754908 creator A5090715650 @default.
- W4385754908 date "2023-09-01" @default.
- W4385754908 modified "2023-10-02" @default.
- W4385754908 title "Characterisation of the UK High Energy Proton Research Beamline for High and Ultra-High Dose Rate (FLASH) Irradiation" @default.
- W4385754908 cites W2038739812 @default.
- W4385754908 cites W2043603625 @default.
- W4385754908 cites W2104891102 @default.
- W4385754908 cites W2116605249 @default.
- W4385754908 cites W2838179470 @default.
- W4385754908 cites W2891850544 @default.
- W4385754908 cites W2936488270 @default.
- W4385754908 cites W2954726425 @default.
- W4385754908 cites W2955197199 @default.
- W4385754908 cites W3033370983 @default.
- W4385754908 cites W3045635238 @default.
- W4385754908 cites W3085312882 @default.
- W4385754908 cites W3179678643 @default.
- W4385754908 doi "https://doi.org/10.1088/2057-1976/acef25" @default.
- W4385754908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37567152" @default.
- W4385754908 hasPublicationYear "2023" @default.
- W4385754908 type Work @default.
- W4385754908 citedByCount "0" @default.
- W4385754908 crossrefType "journal-article" @default.
- W4385754908 hasAuthorship W4385754908A5002396853 @default.
- W4385754908 hasAuthorship W4385754908A5024868123 @default.
- W4385754908 hasAuthorship W4385754908A5034350645 @default.
- W4385754908 hasAuthorship W4385754908A5046093888 @default.
- W4385754908 hasAuthorship W4385754908A5050287039 @default.
- W4385754908 hasAuthorship W4385754908A5068022992 @default.
- W4385754908 hasAuthorship W4385754908A5080277966 @default.
- W4385754908 hasAuthorship W4385754908A5090715650 @default.
- W4385754908 hasBestOaLocation W43857549081 @default.
- W4385754908 hasConcept C102637530 @default.
- W4385754908 hasConcept C111337013 @default.
- W4385754908 hasConcept C120665830 @default.
- W4385754908 hasConcept C121332964 @default.
- W4385754908 hasConcept C136959337 @default.
- W4385754908 hasConcept C168834538 @default.
- W4385754908 hasConcept C180541544 @default.
- W4385754908 hasConcept C185544564 @default.
- W4385754908 hasConcept C192562407 @default.
- W4385754908 hasConcept C2775881188 @default.
- W4385754908 hasConcept C2779244869 @default.
- W4385754908 hasConcept C50774322 @default.
- W4385754908 hasConcept C54516573 @default.
- W4385754908 hasConcept C94915269 @default.
- W4385754908 hasConceptScore W4385754908C102637530 @default.
- W4385754908 hasConceptScore W4385754908C111337013 @default.
- W4385754908 hasConceptScore W4385754908C120665830 @default.
- W4385754908 hasConceptScore W4385754908C121332964 @default.
- W4385754908 hasConceptScore W4385754908C136959337 @default.
- W4385754908 hasConceptScore W4385754908C168834538 @default.
- W4385754908 hasConceptScore W4385754908C180541544 @default.
- W4385754908 hasConceptScore W4385754908C185544564 @default.
- W4385754908 hasConceptScore W4385754908C192562407 @default.
- W4385754908 hasConceptScore W4385754908C2775881188 @default.
- W4385754908 hasConceptScore W4385754908C2779244869 @default.
- W4385754908 hasConceptScore W4385754908C50774322 @default.
- W4385754908 hasConceptScore W4385754908C54516573 @default.
- W4385754908 hasConceptScore W4385754908C94915269 @default.
- W4385754908 hasFunder F4320314451 @default.
- W4385754908 hasFunder F4320329621 @default.
- W4385754908 hasFunder F4320332999 @default.
- W4385754908 hasFunder F4320334627 @default.
- W4385754908 hasFunder F4320334632 @default.
- W4385754908 hasIssue "5" @default.
- W4385754908 hasLocation W43857549081 @default.
- W4385754908 hasLocation W43857549082 @default.
- W4385754908 hasOpenAccess W4385754908 @default.
- W4385754908 hasPrimaryLocation W43857549081 @default.
- W4385754908 hasRelatedWork W2031883045 @default.
- W4385754908 hasRelatedWork W2074019600 @default.
- W4385754908 hasRelatedWork W2098736080 @default.
- W4385754908 hasRelatedWork W2418560143 @default.
- W4385754908 hasRelatedWork W2557330280 @default.
- W4385754908 hasRelatedWork W2765384953 @default.
- W4385754908 hasRelatedWork W2907837704 @default.
- W4385754908 hasRelatedWork W3029117906 @default.
- W4385754908 hasRelatedWork W3134599801 @default.
- W4385754908 hasRelatedWork W4378695512 @default.
- W4385754908 hasVolume "9" @default.
- W4385754908 isParatext "false" @default.
- W4385754908 isRetracted "false" @default.
- W4385754908 workType "article" @default.