FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385755377> ?p ?o ?g. }

• W4385755377 abstract "Melanoma is a dreadful skin malignancy caused by genetic mutations in melanocytes. The inherent unresponsiveness of melanoma cells to conventional therapies leads to uncontrollable tumour growth and alarming fatalities rates. Photodynamic therapy (PDT) is a novel therapeutic option for the eradication of malignant tumours and, compared to traditional therapies, is minimally invasive and exhibits increased efficacy. Currently, most PDT experiments are still conducted on two-dimensional (2-D) monoculture, which may not sufficiently mimic the physiological conditions and the three-dimensional (3-D) architecture of native tumours. Therefore, 3-D cell cultures serve as excellent models to replicate tumour tissue in terms of structural and functional properties. Commercially available A375 melanoma cells were cultivated as monolayers and 3-D tumour spheroids for this study. A375 cells were treated with zinc phthalocyanine tetrasulfonic acid (ZnPcS₄) at varying doses (0.125-20 μM) and photoactivation was achieved using a 673 nm diode laser at a fluency of 10 J/cm². Photoactivated ZnPcS₄ resulted in a dose-dependent reduction in cell proliferation, and increased cytotoxicity as determined by adenosine 5′-triphosphate (ATP), and lactate dehydrogenase (LDH) assay respectively. Morphological changes also confirmed the phototoxic effect of ZnPcS4, while cell death pathways were detected via annexin V-FITC-PI. The half-maximal inhibitory concentration (IC₅₀) of ZnPcS₄-mediated PDT on 3-D tumour spheroids was higher than that of monolayers. In conclusion, 3-D cell cultures are unresponsive to PDT compared to traditional monolayer cell cultures and can therefore provide more realistic data and reduce significant discrepancies between in vitro and in vivo studies for better prediction in clinical responses." @default.
• W4385755377 created "2023-08-12" @default.
• W4385755377 creator A5066427986 @default.
• W4385755377 creator A5072586638 @default.
• W4385755377 date "2023-08-11" @default.
• W4385755377 modified "2023-09-27" @default.
• W4385755377 title "The phototoxic effect of zinc phthalocyanine on melanoma cells grown as a monolayer and three-dimensional multicellular spheroids" @default.
• W4385755377 cites W2043391104 @default.
• W4385755377 cites W2094321727 @default.
• W4385755377 cites W2130276070 @default.
• W4385755377 cites W2884145325 @default.
• W4385755377 cites W2885252184 @default.
• W4385755377 cites W2896570564 @default.
• W4385755377 cites W2990604092 @default.
• W4385755377 cites W3000058196 @default.
• W4385755377 cites W3041339162 @default.
• W4385755377 cites W3120088722 @default.
• W4385755377 cites W4251274795 @default.
• W4385755377 cites W4252078598 @default.
• W4385755377 cites W4285499893 @default.
• W4385755377 cites W4308768398 @default.
• W4385755377 cites W4318596164 @default.
• W4385755377 doi "https://doi.org/10.1117/12.2675718" @default.
• W4385755377 hasPublicationYear "2023" @default.
• W4385755377 type Work @default.
• W4385755377 citedByCount "0" @default.
• W4385755377 crossrefType "proceedings-article" @default.
• W4385755377 hasAuthorship W4385755377A5066427986 @default.
• W4385755377 hasAuthorship W4385755377A5072586638 @default.
• W4385755377 hasConcept C109316439 @default.
• W4385755377 hasConcept C117262875 @default.
• W4385755377 hasConcept C12554922 @default.
• W4385755377 hasConcept C1491633281 @default.
• W4385755377 hasConcept C153911025 @default.
• W4385755377 hasConcept C178790620 @default.
• W4385755377 hasConcept C185592680 @default.
• W4385755377 hasConcept C202751555 @default.
• W4385755377 hasConcept C20639190 @default.
• W4385755377 hasConcept C2777658100 @default.
• W4385755377 hasConcept C2779671804 @default.
• W4385755377 hasConcept C2781323092 @default.
• W4385755377 hasConcept C502942594 @default.
• W4385755377 hasConcept C55493867 @default.
• W4385755377 hasConcept C86803240 @default.
• W4385755377 hasConceptScore W4385755377C109316439 @default.
• W4385755377 hasConceptScore W4385755377C117262875 @default.
• W4385755377 hasConceptScore W4385755377C12554922 @default.
• W4385755377 hasConceptScore W4385755377C1491633281 @default.
• W4385755377 hasConceptScore W4385755377C153911025 @default.
• W4385755377 hasConceptScore W4385755377C178790620 @default.
• W4385755377 hasConceptScore W4385755377C185592680 @default.
• W4385755377 hasConceptScore W4385755377C202751555 @default.
• W4385755377 hasConceptScore W4385755377C20639190 @default.
• W4385755377 hasConceptScore W4385755377C2777658100 @default.
• W4385755377 hasConceptScore W4385755377C2779671804 @default.
• W4385755377 hasConceptScore W4385755377C2781323092 @default.
• W4385755377 hasConceptScore W4385755377C502942594 @default.
• W4385755377 hasConceptScore W4385755377C55493867 @default.
• W4385755377 hasConceptScore W4385755377C86803240 @default.
• W4385755377 hasLocation W43857553771 @default.
• W4385755377 hasOpenAccess W4385755377 @default.
• W4385755377 hasPrimaryLocation W43857553771 @default.
• W4385755377 hasRelatedWork W2018664136 @default.
• W4385755377 hasRelatedWork W2090856010 @default.
• W4385755377 hasRelatedWork W2106657114 @default.
• W4385755377 hasRelatedWork W2153039004 @default.
• W4385755377 hasRelatedWork W23771414 @default.
• W4385755377 hasRelatedWork W2759540226 @default.
• W4385755377 hasRelatedWork W2791888206 @default.
• W4385755377 hasRelatedWork W2937022739 @default.
• W4385755377 hasRelatedWork W3127979394 @default.
• W4385755377 hasRelatedWork W3158201368 @default.
• W4385755377 isParatext "false" @default.
• W4385755377 isRetracted "false" @default.
• W4385755377 workType "article" @default.