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- W4385755761 abstract "Vincristine is a mainstay treatment for paediatric cancers, particularly acute lymphoblastic leukemia (ALL), with common toxicity including vincristine-induced peripheral neuropathy (VIPN). The present study comprehensively assessed VIPN outcomes in patients receiving vincristine treatment for ALL. Children diagnosed with ALL commencing vincristine treatment were prospectively evaluated (baseline, post-induction, pre-reinduction, post-reinduction, follow-up). VIPN was examined clinically using the Balis sensory/motor scale, neurophysiologically using axonal excitability techniques and quality-of-life using Pediatric Quality of Life Inventory. Thirty-one patients were recruited to this study (age=6.8±4.4; 61.3% female). Incidence of motor VIPN (motor Balis grade>0) symptoms were higher than sensory VIPN (sensory Balis grade>0) at post-induction (92.0% vs 36.0%) and post-reinduction (81.8% vs 22.7%) vincristine treatment. Neurophysiological assessment also demonstrated greater change in motor axonal excitability parameters compared to sensory parameters including changes in depolarising threshold electrotonus (P<0.0125), superexcitability and subexcitability parameters (all P<0.0125). Follow-up assessment demonstrated persisting VIPN symptoms with reduced quality-of-life scores compared to baseline. Clinical and neurophysiological evaluation of VIPN suggests vincristine produces a motor-prominent sensorimotor neuropathy in children which persisted at follow-up. VIPN signs and symptoms develop early in the treatment course, in line with axonal excitability profiles. Early detection of significant nerve changes may support timely implementation of neuroprotection strategies." @default.
- W4385755761 created "2023-08-12" @default.
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- W4385755761 date "2023-10-01" @default.
- W4385755761 modified "2023-10-17" @default.
- W4385755761 title "Prospective assessment of vincristine-induced peripheral neuropathy in paediatric acute lymphoblastic leukemia" @default.
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- W4385755761 doi "https://doi.org/10.1016/j.clinph.2023.08.002" @default.
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