Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385757203> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4385757203 endingPage "168228" @default.
- W4385757203 startingPage "168228" @default.
- W4385757203 abstract "Data on safety of thrombolysis for acute ischemic stroke (AIS) in patients with hematologic malignancy is not well established. We report our single institution experience with thrombolysis in this patient population.We identified patients with pathology-confirmed hematologic malignancy from 2000-2022. Primary exposure was presence of AIS and receipt of intravenous (IV) thrombolysis. Primary outcome was safety of IV thrombolysis in this patient population. Safety was measured through imaging review for hemorrhagic transformation, post-stroke mortality, and modified Rankin Scale (mRS) at 90 days.Among 45,894 patients with hematologic malignancy, 1,099 (2.4%) were identified as having a suspected AIS. Twenty (1.8%) received IV tissue plasminogen activator (tPA) for AIS, three underwent endovascular intervention, and 17 had AIS confirmed on MRI. Two patients with confirmed AIS experienced hemorrhagic transformation, one of which was symptomatic. Most patients (n=10, 59%) were functionally independent (mRS 0-2) at 90 days post-stroke, including all patients with active hematologic malignancy at the time of stroke (n=3). Four patients died within 90 days of AIS. None of these deaths were patients with active hematologic malignancy at the time of stroke.Without other contraindications, IV alteplase should be considered for management of AIS in patients with hematologic malignancy. The safety profile of tPA administration in this patient population may be similar to the general population, whether underlying hematologic malignancy is active or in remission." @default.
- W4385757203 created "2023-08-12" @default.
- W4385757203 date "2023-09-01" @default.
- W4385757203 modified "2023-09-28" @default.
- W4385757203 title "Outside Front Cover" @default.
- W4385757203 doi "https://doi.org/10.1016/s0022-2836(23)00338-8" @default.
- W4385757203 hasPublicationYear "2023" @default.
- W4385757203 type Work @default.
- W4385757203 citedByCount "0" @default.
- W4385757203 crossrefType "journal-article" @default.
- W4385757203 hasConcept C126322002 @default.
- W4385757203 hasConcept C127413603 @default.
- W4385757203 hasConcept C141071460 @default.
- W4385757203 hasConcept C197934379 @default.
- W4385757203 hasConcept C2776572282 @default.
- W4385757203 hasConcept C2779399171 @default.
- W4385757203 hasConcept C2779581417 @default.
- W4385757203 hasConcept C2780645631 @default.
- W4385757203 hasConcept C2780931571 @default.
- W4385757203 hasConcept C2908647359 @default.
- W4385757203 hasConcept C3020199598 @default.
- W4385757203 hasConcept C500558357 @default.
- W4385757203 hasConcept C541997718 @default.
- W4385757203 hasConcept C71924100 @default.
- W4385757203 hasConcept C78519656 @default.
- W4385757203 hasConcept C99454951 @default.
- W4385757203 hasConceptScore W4385757203C126322002 @default.
- W4385757203 hasConceptScore W4385757203C127413603 @default.
- W4385757203 hasConceptScore W4385757203C141071460 @default.
- W4385757203 hasConceptScore W4385757203C197934379 @default.
- W4385757203 hasConceptScore W4385757203C2776572282 @default.
- W4385757203 hasConceptScore W4385757203C2779399171 @default.
- W4385757203 hasConceptScore W4385757203C2779581417 @default.
- W4385757203 hasConceptScore W4385757203C2780645631 @default.
- W4385757203 hasConceptScore W4385757203C2780931571 @default.
- W4385757203 hasConceptScore W4385757203C2908647359 @default.
- W4385757203 hasConceptScore W4385757203C3020199598 @default.
- W4385757203 hasConceptScore W4385757203C500558357 @default.
- W4385757203 hasConceptScore W4385757203C541997718 @default.
- W4385757203 hasConceptScore W4385757203C71924100 @default.
- W4385757203 hasConceptScore W4385757203C78519656 @default.
- W4385757203 hasConceptScore W4385757203C99454951 @default.
- W4385757203 hasIssue "17" @default.
- W4385757203 hasLocation W43857572031 @default.
- W4385757203 hasOpenAccess W4385757203 @default.
- W4385757203 hasPrimaryLocation W43857572031 @default.
- W4385757203 hasRelatedWork W1509608683 @default.
- W4385757203 hasRelatedWork W1975937957 @default.
- W4385757203 hasRelatedWork W2171891409 @default.
- W4385757203 hasRelatedWork W2478674974 @default.
- W4385757203 hasRelatedWork W2617664251 @default.
- W4385757203 hasRelatedWork W2729951699 @default.
- W4385757203 hasRelatedWork W2733387219 @default.
- W4385757203 hasRelatedWork W2885966173 @default.
- W4385757203 hasRelatedWork W2895046280 @default.
- W4385757203 hasRelatedWork W4385657555 @default.
- W4385757203 hasVolume "435" @default.
- W4385757203 isParatext "false" @default.
- W4385757203 isRetracted "false" @default.
- W4385757203 workType "article" @default.